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Publikationen

Publikationen von Christoph Bock

2024

  • Saito T., Espe M., Vikesa V., Bock C., Thomsen T.H., Adam A.-C., Fernandes J.M.O., Skjaerven K.H.
    One-Carbon Metabolism Nutrients Impact the Interplay between DNA Methylation and Gene Expression in Liver, Enhancing Protein Synthesis in Atlantic Salmon.
    Epigenetics 19:2318517, (2024) [bib]
    
    @ARTICLE{saito2024omni2318517,
      author = {Saito, T.~ and Espe, M.~ and Vikesa, V.~ and Bock, C.~ and Thomsen, T.H.~ and Adam, A.-C.~ and Fernandes, J.M.O.~ and Skjaerven, K.H.~},
      title = {One-Carbon Metabolism Nutrients Impact the Interplay between DNA Methylation and Gene Expression in Liver, Enhancing Protein Synthesis in Atlantic Salmon.},
      journal = {Epigenetics},
      year = {2024},
      volume = {19},
      pages = {2318517},
      doi = {10.1080/15592294.2024.2318517}
    }
  • Stolz V., Silva R.d.F., Rica R., Zhu C., Preglej T., Hamminger P., Hainberger D., Alteneder M., Muller L., Waldherr M., Waltenberger D., Hladik A., Agerer B., Schuster M., Frey T., Krausgruber T., Knapp S., Campbell C., Schmetterer K., Trauner M., Bergthaler A., Bock C., Boucheron N., Ellmeier W.
    Nuclear Receptor Corepressor 1 Controls Regulatory T Cell Subset Differentiation and Effector Function.
    eLife 13:e78738, (2024) [bib]
    
    @ARTICLE{stolz2024nrc1e78738,
      author = {Stolz, V.~ and Silva, R.d.F.~ and Rica, R.~ and Zhu, C.~ and Preglej, T.~ and Hamminger, P.~ and Hainberger, D.~ and Alteneder, M.~ and Muller, L.~ and Waldherr, M.~ and Waltenberger, D.~ and Hladik, A.~ and Agerer, B.~ and Schuster, M.~ and Frey, T.~ and Krausgruber, T.~ and Knapp, S.~ and Campbell, C.~ and Schmetterer, K.~ and Trauner, M.~ and Bergthaler, A.~ and Bock, C.~ and Boucheron, N.~ and Ellmeier, W.~},
      title = {Nuclear Receptor Corepressor 1 Controls Regulatory T Cell Subset Differentiation and Effector Function.},
      journal = {eLife},
      year = {2024},
      volume = {13},
      pages = {e78738},
      doi = {10.7554/eLife.78738}
    }
  • Schaefer M., Peneder P., Malzl D., Peycheva M., Burton J., Hakobyan A., Sharma V., Krausgruber T., Menche J., Tomazou E.M., Bock C.
    Multimodal Learning of Transcriptomes and Text Enables Interactive Single-Cell RNA-Seq Data Exploration with Natural-Language Chats.
    bioRxiv 2024.10.15.618501, (2024) [bib]
    
    @ARTICLE{schaefer2024mltt20241015618501,
      author = {Schaefer, M.~ and Peneder, P.~ and Malzl, D.~ and Peycheva, M.~ and Burton, J.~ and Hakobyan, A.~ and Sharma, V.~ and Krausgruber, T.~ and Menche, J.~ and Tomazou, E.M.~ and Bock, C.~},
      title = {Multimodal Learning of Transcriptomes and Text Enables Interactive Single-Cell RNA-Seq Data Exploration with Natural-Language Chats.},
      journal = {bioRxiv},
      year = {2024},
      pages = {2024.10.15.618501},
      doi = {10.1101/2024.10.15.618501},
      url = {http://biorxiv.org/content/early/2024/10/18/2024.10.15.618501.abstract}
    }
  • Schmitt M.T., Ruiz-Fernandez M.J., Stefanowski K., Kroll J., Hauschild R., Merrin J., Penz T., Kiermaier E., Bock C., Straub T., Renkawitz J.
    Mechanical Centrosome Fracturing during Cell Navigation.
    bioRxiv 2024.10.01.615992, (2024) [bib]
    
    @ARTICLE{schmitt2024mcfd20241001615992,
      author = {Schmitt, M.T.~ and Ruiz-Fernandez, M.J.~ and Stefanowski, K.~ and Kroll, J.~ and Hauschild, R.~ and Merrin, J.~ and Penz, T.~ and Kiermaier, E.~ and Bock, C.~ and Straub, T.~ and Renkawitz, J.~},
      title = {Mechanical Centrosome Fracturing during Cell Navigation.},
      journal = {bioRxiv},
      year = {2024},
      pages = {2024.10.01.615992},
      doi = {10.1101/2024.10.01.615992}
    }
  • Lin Y.-Y., Breuer K., Weichenhan D., Lafrenz P., Wilk A., Chepeleva M., Mücke O., Schönung M., Petermann F., Kensche P., Weiser L., Thommen F., Giacomelli G., Nordstroem K., Gonzales-Avalos E., Merkel A., Kretzmer H., Fischer J., Krämer S., Iskar M., Wolf S., Buchhalter I., Esteller M., Lawerenz C., Twardziok S., Zapatka M., Hovestadt V., Schlesner M., Schulz M., Hoffmann S., Gerhauser C., Walter J., Hartmann M., Lipka D.B., Assenov Y., Bock C., Plass C., Toth R., Lutsik P.
    Pipeline Olympics: Continuable Benchmarking of Computational Workflows for DNA Methylation Sequencing Data against an Experimental Gold-Standard.
    bioRxiv 2024.09.16.609142, (2024) [bib]
    
    @ARTICLE{lin2024pocb20240916609142,
      author = {Lin, Y.-Y.~ and Breuer, K.~ and Weichenhan, D.~ and Lafrenz, P.~ and Wilk, A.~ and Chepeleva, M.~ and M{\"u}cke, O.~ and Sch{\"o}nung, M.~ and Petermann, F.~ and Kensche, P.~ and Weiser, L.~ and Thommen, F.~ and Giacomelli, G.~ and Nordstroem, K.~ and Gonzales-Avalos, E.~ and Merkel, A.~ and Kretzmer, H.~ and Fischer, J.~ and Kr{\"a}mer, S.~ and Iskar, M.~ and Wolf, S.~ and Buchhalter, I.~ and Esteller, M.~ and Lawerenz, C.~ and Twardziok, S.~ and Zapatka, M.~ and Hovestadt, V.~ and Schlesner, M.~ and Schulz, M.~ and Hoffmann, S.~ and Gerhauser, C.~ and Walter, J.~ and Hartmann, M.~ and Lipka, D.B.~ and Assenov, Y.~ and Bock, C.~ and Plass, C.~ and Toth, R.~ and Lutsik, P.~},
      title = {Pipeline Olympics: Continuable Benchmarking of Computational Workflows for DNA Methylation Sequencing Data against an Experimental Gold-Standard.},
      journal = {bioRxiv},
      year = {2024},
      pages = {2024.09.16.609142},
      doi = {10.1101/2024.09.16.609142},
      url = {http://biorxiv.org/content/early/2024/09/19/2024.09.16.609142.abstract}
    }
  • Schaefer M., Reichl S., Ter Horst R., Nicolas A.M., Krausgruber T., Piras F., Stepper P., Bock C., Samwald M.
    GPT-4 as a Biomedical Simulator.
    Computers in Biology and Medicine 178:108796, (2024) [bib]
    
    @ARTICLE{schaefer2024gaab108796,
      author = {Schaefer, M.~ and Reichl, S.~ and Ter Horst, R.~ and Nicolas, A.M.~ and Krausgruber, T.~ and Piras, F.~ and Stepper, P.~ and Bock, C.~ and Samwald, M.~},
      title = {GPT-4 as a Biomedical Simulator.},
      journal = {Computers in Biology and Medicine},
      year = {2024},
      volume = {178},
      pages = {108796},
      issn = {1879-0534 0010-4825},
      doi = {10.1016/j.compbiomed.2024.108796},
      keywords = {Artificial intelligence;Computational biology;Large language models;Biomedical simulation;GPT-4}
    }
  • Saito T., Espe M., Mommens M., Bock C., Fernandes J.M., Skjaerven K.H.
    Altered Spawning Seasons of Atlantic Salmon Broodstock Genetically and Epigenetically Influence Cell Cycle and Lipid-Mediated Regulations in Their Offspring.
    bioRxiv 2024.02.03.578741, (2024) [bib]
    
    @ARTICLE{saito2024assa20240203578741,
      author = {Saito, T.~ and Espe, M.~ and Mommens, M.~ and Bock, C.~ and Fernandes, J.M.~ and Skjaerven, K.H.~},
      title = {Altered Spawning Seasons of Atlantic Salmon Broodstock Genetically and Epigenetically Influence Cell Cycle and Lipid-Mediated Regulations in Their Offspring.},
      journal = {bioRxiv},
      year = {2024},
      pages = {2024.02.03.578741},
      doi = {10.1101/2024.02.03.578741}
    }
  • Enk L.U.B., Hellmig M., Riecken K., Kilian C., Datlinger P., Jauch-Speer S.L., Neben T., Sultana Z., Sivayoganathan V., Borchers A., Paust H.-J., Zhao Y., Asada N., Liu S., Agalioti T., Pelczar P., Wiech T., Bock C., Huber T.B., Huber S., Bonn S., Gagliani N., Fehse B., Panzer U., Krebs C.F.
    Targeting T Cell Plasticity in Kidney and Gut Inflammation by Pooled Single-Cell CRISPR Screening.
    Science Immunology 9(96):eadd6774, (2024) [bib]
    
    @ARTICLE{enk2024ttcpeadd6774,
      author = {Enk, L.U.B.~ and Hellmig, M.~ and Riecken, K.~ and Kilian, C.~ and Datlinger, P.~ and Jauch-Speer, S.L.~ and Neben, T.~ and Sultana, Z.~ and Sivayoganathan, V.~ and Borchers, A.~ and Paust, H.-J.~ and Zhao, Y.~ and Asada, N.~ and Liu, S.~ and Agalioti, T.~ and Pelczar, P.~ and Wiech, T.~ and Bock, C.~ and Huber, T.B.~ and Huber, S.~ and Bonn, S.~ and Gagliani, N.~ and Fehse, B.~ and Panzer, U.~ and Krebs, C.F.~},
      title = {Targeting T Cell Plasticity in Kidney and Gut Inflammation by Pooled Single-Cell CRISPR Screening.},
      journal = {Science Immunology},
      year = {2024},
      volume = {9},
      number = {96},
      pages = {eadd6774},
      issn = {2470-9468},
      doi = {10.1126/sciimmunol.add6774},
      keywords = {Animals;Female;Humans;Male;Mice;Mice;Inbred C57BL;*Single-Cell Analysis;*Th17 Cells/immunology;Cell Plasticity/immunology/genetics;Clustered Regularly Interspaced Short Palindromic Repeats/immunology;Colitis/immunology/genetics;CRISPR-Cas Systems;Glomerulonephritis/immunology/genetics;Inflammation/immunology/genetics;Kidney/immunology/pathology}
    }
  • Slim M.A., van Mourik N., Bakkerus L., Fuller K., Acharya L., Giannidis T., Dionne J.C., Oczkowski S.J.W., Netea M.G., Pickkers P., Giamarellos-Bourboulis E.J., Muller M.C.A., van der Poll T., Wiersinga W.J., Vlaar A.P.J., van Vught L.A., ImmunoSep Consortium: Bock C.
    Towards Personalized Medicine: A Scoping Review of Immunotherapy in Sepsis.
    Critical Care 28:183, (2024) [bib]
    
    @ARTICLE{slim2024tpma183,
      author = {Slim, M.A.~ and van Mourik, N.~ and Bakkerus, L.~ and Fuller, K.~ and Acharya, L.~ and Giannidis, T.~ and Dionne, J.C.~ and Oczkowski, S.J.W.~ and Netea, M.G.~ and Pickkers, P.~ and Giamarellos-Bourboulis, E.J.~ and Muller, M.C.A.~ and van der Poll, T.~ and Wiersinga, W.J.~ and Vlaar, A.P.J.~ and van Vught, L.A.~ and {ImmunoSep Consortium}},
      title = {Towards Personalized Medicine: A Scoping Review of Immunotherapy in Sepsis.},
      journal = {Critical Care},
      year = {2024},
      volume = {28},
      pages = {183},
      doi = {10.1186/s13054-024-04964-6}
    }
  • Novarino G., Bock C.
    Mapping the Brain’s Gene-Regulatory Maze.
    Science 384(6698), 860–861, (2024) [bib]
    
    @ARTICLE{novarino2024mbgm860861,
      author = {Novarino, G.~ and Bock, C.~},
      title = {Mapping the Brain’s Gene-Regulatory Maze.},
      journal = {Science},
      year = {2024},
      volume = {384},
      number = {6698},
      pages = {860--861},
      doi = {10.1126/science.adp4663}
    }
  • Lim C.X., Redl A., Kleissl L., Pandey R.V., Mayerhofer C., El Jammal T., Mazic M., Gonzales K., Sukhbaatar N., Krausgruber T., Bock C., Hengstschläger M., Calender A., Pacheco Y., Stary G., Weichhart T.
    Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis.
    American Journal of Respiratory and Critical Care Medicine 209(9), 1152–1164, (2024) [bib]
    
    @ARTICLE{lim2024almm11521164,
      author = {Lim, C.X.~ and Redl, A.~ and Kleissl, L.~ and Pandey, R.V.~ and Mayerhofer, C.~ and El Jammal, T.~ and Mazic, M.~ and Gonzales, K.~ and Sukhbaatar, N.~ and Krausgruber, T.~ and Bock, C.~ and Hengstschl{\"a}ger, M.~ and Calender, A.~ and Pacheco, Y.~ and Stary, G.~ and Weichhart, T.~},
      title = {Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis.},
      journal = {American Journal of Respiratory and Critical Care Medicine},
      year = {2024},
      volume = {209},
      number = {9},
      pages = {1152--1164},
      issn = {1535-4970 1073-449X},
      doi = {10.1164/rccm.202307-1273OC},
      keywords = {macrophages;mTOR;lipid metabolism;sarcoidosis}
    }
  • Kocher K., Moosmann C., Drost F., Schülein C., Irrgang P., Steininger P., Zhong J., Träger J., Spriewald B., Bock C., Busch D.H., Bogdan C., Schubert B., Winkler T.H., Tenbusch M., Schuster E.-M., Schober K.
    Adaptive Immune Responses Are Larger and Functionally Preserved in a Hypervaccinated Individual.
    Lancet Infectious Diseases 24(5), e272–e274, (2024) [bib]
    
    @ARTICLE{kocher2024airae272e274,
      author = {Kocher, K.~ and Moosmann, C.~ and Drost, F.~ and Sch{\"u}lein, C.~ and Irrgang, P.~ and Steininger, P.~ and Zhong, J.~ and Tr{\"a}ger, J.~ and Spriewald, B.~ and Bock, C.~ and Busch, D.H.~ and Bogdan, C.~ and Schubert, B.~ and Winkler, T.H.~ and Tenbusch, M.~ and Schuster, E.-M.~ and Schober, K.~},
      title = {Adaptive Immune Responses Are Larger and Functionally Preserved in a Hypervaccinated Individual.},
      journal = {Lancet Infectious Diseases},
      year = {2024},
      volume = {24},
      number = {5},
      pages = {e272--e274},
      issn = {1474-4457 1473-3099},
      doi = {10.1016/S1473-3099(24)00134-8}
    }
  • Fortelny N., Farlik M., Fife V., Gorki A.-D., Lassnig C., Maurer B., Meissl K., Dolezal M., Boccuni L., Ravi Sundar Jose Geetha A., Akagha M.J., Karjalainen A., Shoebridge S., Farhat A., Mann U., Jain R., Tikoo S., Zila N., Esser-Skala W., Krausgruber T., Sitnik K., Penz T., Hladik A., Suske T., Zahalka S., Senekowitsch M., Barreca D., Halbritter F., Macho-Maschler S., Weninger W., Neubauer H.A., Moriggl R., Knapp S., Sexl V., Strobl B., Decker T., Müller M., Bock C.
    JAK-STAT Signaling Maintains Homeostasis in T Cells and Macrophages.
    Nature Immunology 25(5), 847–859, (2024) [bib]
    
    @ARTICLE{fortelny2024jsmh847859,
      author = {Fortelny, N.~ and Farlik, M.~ and Fife, V.~ and Gorki, A.-D.~ and Lassnig, C.~ and Maurer, B.~ and Meissl, K.~ and Dolezal, M.~ and Boccuni, L.~ and Ravi Sundar Jose Geetha, A.~ and Akagha, M.J.~ and Karjalainen, A.~ and Shoebridge, S.~ and Farhat, A.~ and Mann, U.~ and Jain, R.~ and Tikoo, S.~ and Zila, N.~ and Esser-Skala, W.~ and Krausgruber, T.~ and Sitnik, K.~ and Penz, T.~ and Hladik, A.~ and Suske, T.~ and Zahalka, S.~ and Senekowitsch, M.~ and Barreca, D.~ and Halbritter, F.~ and Macho-Maschler, S.~ and Weninger, W.~ and Neubauer, H.A.~ and Moriggl, R.~ and Knapp, S.~ and Sexl, V.~ and Strobl, B.~ and Decker, T.~ and M{\"u}ller, M.~ and Bock, C.~},
      title = {JAK-STAT Signaling Maintains Homeostasis in T Cells and Macrophages.},
      journal = {Nature Immunology},
      year = {2024},
      volume = {25},
      number = {5},
      pages = {847--859},
      issn = {1529-2916 1529-2908},
      doi = {10.1038/s41590-024-01804-1},
      keywords = {Animals;Mice;Mice;Inbred C57BL;*Homeostasis;*Signal Transduction;Gene Expression Regulation;*Janus Kinases/metabolism;*Macrophages/immunology/metabolism;*Mice;Knockout;*STAT Transcription Factors/metabolism;CD8-Positive T-Lymphocytes/immunology/metabolism;Interferon-Stimulated Gene Factor 3;gamma Subunit/metabolism/genetics;STAT1 Transcription Factor/metabolism/genetics;TYK2 Kinase/metabolism/genetics}
    }
  • Bock C., Decker T., Müller M.
    Baseline JAK-STAT Signaling Maintains Immune Cell Homeostasis.
    Nature Immunology 25(5), 741–742, (2024) [bib]
    
    @ARTICLE{bock2024bjsm741742,
      author = {Bock, C.~ and Decker, T.~ and M{\"u}ller, M.~},
      title = {Baseline JAK-STAT Signaling Maintains Immune Cell Homeostasis.},
      journal = {Nature Immunology},
      year = {2024},
      volume = {25},
      number = {5},
      pages = {741--742},
      issn = {1529-2908},
      doi = {10.1038/s41590-024-01805-0}
    }
  • Suske T., Sorger H., Manhart G., Ruge F., Prutsch N., Zimmerman M.W., Eder T., Abdallah D.I., Maurer B., Wagner C., Schonefeldt S., Spirk K., Pichler A., Pemovska T., Schweicker C., Poloske D., Hubanic E., Jungherz D., Muller T.A., Aung M.M.K., Orlova A., Pham H.T.T., Zimmel K., Krausgruber T., Bock C., Muller M., Dahlhoff M., Boersma A., Rulicke T., Fleck R., de Araujo E.D., Gunning P.T., Aittokallio T., Mustjoki S., Sanda T., Hartmann S., Grebien F., Hoermann G., Haferlach T., Staber P.B., Neubauer H.A., Look A.T., Herling M., Moriggl R.
    Hyperactive STAT5 Hijacks T Cell Receptor Signaling and Drives Immature T Cell Acute Lymphoblastic Leukemia.
    Journal of Clinical Investigation 134(8):e168536, (2024) [bib]
    
    @ARTICLE{suske2024hshte168536,
      author = {Suske, T.~ and Sorger, H.~ and Manhart, G.~ and Ruge, F.~ and Prutsch, N.~ and Zimmerman, M.W.~ and Eder, T.~ and Abdallah, D.I.~ and Maurer, B.~ and Wagner, C.~ and Schonefeldt, S.~ and Spirk, K.~ and Pichler, A.~ and Pemovska, T.~ and Schweicker, C.~ and Poloske, D.~ and Hubanic, E.~ and Jungherz, D.~ and Muller, T.A.~ and Aung, M.M.K.~ and Orlova, A.~ and Pham, H.T.T.~ and Zimmel, K.~ and Krausgruber, T.~ and Bock, C.~ and Muller, M.~ and Dahlhoff, M.~ and Boersma, A.~ and Rulicke, T.~ and Fleck, R.~ and de Araujo, E.D.~ and Gunning, P.T.~ and Aittokallio, T.~ and Mustjoki, S.~ and Sanda, T.~ and Hartmann, S.~ and Grebien, F.~ and Hoermann, G.~ and Haferlach, T.~ and Staber, P.B.~ and Neubauer, H.A.~ and Look, A.T.~ and Herling, M.~ and Moriggl, R.~},
      title = {Hyperactive STAT5 Hijacks T Cell Receptor Signaling and Drives Immature T Cell Acute Lymphoblastic Leukemia.},
      journal = {Journal of Clinical Investigation},
      year = {2024},
      volume = {134},
      number = {8},
      pages = {e168536},
      doi = {10.1172/JCI168536}
    }
  • Hevesi Z., Bakker J., Tretiakov E.O., Adori C., Raabgrund A., Barde S.S., Caramia M., Krausgruber T., Ladstätter S., Bock C., Hökfelt T., Harkany T.
    Transient Expression of the Neuropeptide Galanin Modulates Peripheral‑to‑Central Connectivity in the Somatosensory Thalamus during Whisker Development in Mice.
    Nature Communications 15:2762, (2024) [bib]
    
    @ARTICLE{hevesi2024teng2762,
      author = {Hevesi, Z.~ and Bakker, J.~ and Tretiakov, E.O.~ and Adori, C.~ and Raabgrund, A.~ and Barde, S.S.~ and Caramia, M.~ and Krausgruber, T.~ and Ladst{\"a}tter, S.~ and Bock, C.~ and H{\"o}kfelt, T.~ and Harkany, T.~},
      title = {Transient Expression of the Neuropeptide Galanin Modulates Peripheral‑to‑Central Connectivity in the Somatosensory Thalamus during Whisker Development in Mice.},
      journal = {Nature Communications},
      year = {2024},
      volume = {15},
      pages = {2762},
      issn = {2041-1723},
      doi = {10.1038/s41467-024-47054-5},
      keywords = {Animals;Humans;Mice;*Galanin/metabolism;*Vibrissae/physiology;Axons/metabolism;Brain/metabolism;Thalamus/metabolism}
    }
  • Malta T.M., Sabedot T.S., Morosini N.S., Datta I., Garofano L., Vallentgoed W., Varn F.S., Aldape K., D’Angelo F., Bakas S., Barnholtz-Sloan J.S., Gan H.K., Hasanain M., Hau A.-C., Johnson K.C., Cazacu S., deCarvalho A.C., Khasraw M., Kocakavuk E., Kouwenhoven M.C.M., Migliozzi S., Niclou S.P., Niers J.M., Ormond D.R., Paek S.H., Reifenberger G., Sillevis Smitt P.A., Smits M., Stead L.F., van den Bent M.J., Van Meir E.G., Walenkamp A., Weiss T., Weller M., Westerman B.A., Ylstra B., Wesseling P., Lasorella A., French P.J., Poisson L.M., The GLASS Consortium, Verhaak R.G.W., Iavarone A., Noushmehr,H. [Bock,C.]
    The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen.
    Cancer Research 84(5), 741–756, (2024) [bib]
    
    @ARTICLE{malta2024eegi741756,
      author = {Malta, T.M.~ and Sabedot, T.S.~ and Morosini, N.S.~ and Datta, I.~ and Garofano, L.~ and Vallentgoed, W.~ and Varn, F.S.~ and Aldape, K.~ and D’Angelo, F.~ and Bakas, S.~ and Barnholtz-Sloan, J.S.~ and Gan, H.K.~ and Hasanain, M.~ and Hau, A.-C.~ and Johnson, K.C.~ and Cazacu, S.~ and deCarvalho, A.C.~ and Khasraw, M.~ and Kocakavuk, E.~ and Kouwenhoven, M.C.M.~ and Migliozzi, S.~ and Niclou, S.P.~ and Niers, J.M.~ and Ormond, D.R.~ and Paek, S.H.~ and Reifenberger, G.~ and Sillevis Smitt, P.A.~ and Smits, M.~ and Stead, L.F.~ and van den Bent, M.J.~ and Van Meir, E.G.~ and Walenkamp, A.~ and Weiss, T.~ and Weller, M.~ and Westerman, B.A.~ and Ylstra, B.~ and Wesseling, P.~ and Lasorella, A.~ and French, P.J.~ and Poisson, L.M.~ and The GLASS, Consortium~ and Verhaak, R.G.W.~ and Iavarone, A.~ and Noushmehr,H.{ }[Bock,C.]},
      title = {The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen.},
      journal = {Cancer Research},
      year = {2024},
      volume = {84},
      number = {5},
      pages = {741--756},
      issn = {1538-7445 0008-5472},
      doi = {10.1158/0008-5472.CAN-23-2093},
      keywords = {Humans;Mutation;Epigenomics;*Brain Neoplasms/pathology;*Glioma/pathology;*Isocitrate Dehydrogenase/genetics/metabolism;Epigenesis;Genetic;Neoplasm Recurrence;Local/genetics;Tumor Microenvironment}
    }
  • Rica R., Waldherr M., Schulein M., Miyakoda E., Sandner L., Stolz V., Waltenberger D., Krausgruber T., Bock C., Boucheron N., Ellmeier W., Sakaguchi S.
    HDAC1 Controls the Generation and Maintenance of Effector-Like CD8+ T Cells during Chronic Viral Infection.
    bioRxiv 2024.02.28.580886, (2024) [bib]
    
    @ARTICLE{rica2024hcgm20240228580886,
      author = {Rica, R.~ and Waldherr, M.~ and Schulein, M.~ and Miyakoda, E.~ and Sandner, L.~ and Stolz, V.~ and Waltenberger, D.~ and Krausgruber, T.~ and Bock, C.~ and Boucheron, N.~ and Ellmeier, W.~ and Sakaguchi, S.~},
      title = {HDAC1 Controls the Generation and Maintenance of Effector-Like CD8+ T Cells during Chronic Viral Infection.},
      journal = {bioRxiv},
      year = {2024},
      pages = {2024.02.28.580886},
      doi = {10.1101/2024.02.28.580886}
    }
  • Braithwaite A.T., Akbar N., Pezzolla D., Paget D., Krausgruber T., Bock C., Carnicer R., Choudhury R.P.
    Multi-Organ Single-Cell RNA Sequencing in Mice Reveals Early Hyperglycemia Responses That Converge on Fibroblast Dysregulation.
    FASEB Journal 38(3):e23448, (2024) [bib]
    
    @ARTICLE{braithwaite2024msrse23448,
      author = {Braithwaite, A.T.~ and Akbar, N.~ and Pezzolla, D.~ and Paget, D.~ and Krausgruber, T.~ and Bock, C.~ and Carnicer, R.~ and Choudhury, R.P.~},
      title = {Multi-Organ Single-Cell RNA Sequencing in Mice Reveals Early Hyperglycemia Responses That Converge on Fibroblast Dysregulation.},
      journal = {FASEB Journal},
      year = {2024},
      volume = {38},
      number = {3},
      pages = {e23448},
      issn = {1530-6860 0892-6638},
      doi = {10.1096/fj.202302003R},
      keywords = {Animals;Male;Mice;Mice;Inbred C57BL;gene expression;fibrosis;mice;hyperglycemia;Sequence Analysis;RNA;*Diabetes Mellitus;Type 1/genetics;*Hyperglycemia/genetics;endothelial cells;Endothelial Cells;monocytes;myofibroblast;RRID:IMSR\_JAX:000664;RRID:SCR\_001618;RRID:SCR\_001905;RRID:SCR\_007322;RRID:SCR\_019010;RRID:SCR\_021946;RRID:SCR\_022146;RRID:SCR\_022254;single-cell RNA-seq;Streptozocin/toxicity;streptozotocin;type 1 diabetes}
    }
  • Redl A., Doberer K., Unterluggauer L., Kleissl L., Krall C., Mayerhofer C., Reininger B., Stary V., Zila N., Weninger W., Weichhart T., Bock C., Krausgruber T., Stary G.
    Efficacy and Safety of mTOR Inhibition in Cutaneous Sarcoidosis: A Single-Centre Trial.
    Lancet Rheumatology 6(2), e81–e91, (2024) [bib]
    
    @ARTICLE{redl2024esmie81e91,
      author = {Redl, A.~ and Doberer, K.~ and Unterluggauer, L.~ and Kleissl, L.~ and Krall, C.~ and Mayerhofer, C.~ and Reininger, B.~ and Stary, V.~ and Zila, N.~ and Weninger, W.~ and Weichhart, T.~ and Bock, C.~ and Krausgruber, T.~ and Stary, G.~},
      title = {Efficacy and Safety of mTOR Inhibition in Cutaneous Sarcoidosis: A Single-Centre Trial.},
      journal = {Lancet Rheumatology},
      year = {2024},
      volume = {6},
      number = {2},
      pages = {e81--e91},
      issn = {2665-9913},
      doi = {10.1016/S2665-9913(23)00302-8}
    }
  • Cheung G., Pauler F.M., Koppensteiner P., Krausgruber T., Streicher C., Schrammel M., Gutmann-Özgen N., Ivec A.E., Bock C., Shigemoto R., Hippenmeyer S.
    Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus.
    Neuron 112(2), 230–246.e11, (2024) [bib]
    
    @ARTICLE{cheung2024mpio230246e11,
      author = {Cheung, G.~ and Pauler, F.M.~ and Koppensteiner, P.~ and Krausgruber, T.~ and Streicher, C.~ and Schrammel, M.~ and Gutmann-{\"O}zgen, N.~ and Ivec, A.E.~ and Bock, C.~ and Shigemoto, R.~ and Hippenmeyer, S.~},
      title = {Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus.},
      journal = {Neuron},
      year = {2024},
      volume = {112},
      number = {2},
      pages = {230--246.e11},
      issn = {1097-4199 0896-6273},
      doi = {10.1016/j.neuron.2023.11.009},
      keywords = {Animals;*Neural Stem Cells/metabolism;*Superior Colliculi/physiology;Cell Lineage/physiology;cell-type diversity;clonal analysis;lineage;MADM;MADM-CloneSeq;Mammals;mosaic analysis with double markers;Neuroglia/metabolism;Neurons/metabolism;radial glial progenitor;RGP;stem cell;superior colliculus}
    }
  • Moorlag S.J.C.F.M., Folkman L., Ter Horst R., Krausgruber T., Barreca D., Schuster L.C., Fife V., Matzaraki V., Li W., Reichl S., Mourits V.P., Koeken V.A.C.M., de Bree L.C.J., Dijkstra H., Lemmers H., van Cranenbroek B., van Rijssen E., Koenen H.J.P.M., Joosten I., Xu C.-J., Li Y., Joosten L.A.B., van Crevel R., Netea M.G., Bock C.
    Multi-Omics Analysis of Innate and Adaptive Responses to BCG Vaccination Reveals Epigenetic Cell States That Predict Trained Immunity.
    Immunity 57(1), 171–187.e14, (2024) [bib]
    
    @ARTICLE{moorlag2024maia171187e14,
      author = {Moorlag, S.J.C.F.M.~ and Folkman, L.~ and Ter Horst, R.~ and Krausgruber, T.~ and Barreca, D.~ and Schuster, L.C.~ and Fife, V.~ and Matzaraki, V.~ and Li, W.~ and Reichl, S.~ and Mourits, V.P.~ and Koeken, V.A.C.M.~ and de Bree, L.C.J.~ and Dijkstra, H.~ and Lemmers, H.~ and van Cranenbroek, B.~ and van Rijssen, E.~ and Koenen, H.J.P.M.~ and Joosten, I.~ and Xu, C.-J.~ and Li, Y.~ and Joosten, L.A.B.~ and van Crevel, R.~ and Netea, M.G.~ and Bock, C.~},
      title = {Multi-Omics Analysis of Innate and Adaptive Responses to BCG Vaccination Reveals Epigenetic Cell States That Predict Trained Immunity.},
      journal = {Immunity},
      year = {2024},
      volume = {57},
      number = {1},
      pages = {171--187.e14},
      doi = {10.1016/j.immuni.2023.12.005}
    }
  • Giamarellos-Bourboulis E.J., Aschenbrenner A.C., Bauer M., Bock C., Calandra T., Gat-Viks I., Kyriazopoulou E., Lupse M., Monneret G., Pickkers P., Schultze J.L., van der Poll T., van de Veerdonk F.L., Vlaar A.P.J., Weis S., Wiersinga W.J., Netea M.G.
    The Pathophysiology of Sepsis and Precision-Medicine-Based Immunotherapy.
    Nature Immunology 25(1), 19–28, (2024) [bib]
    
    @ARTICLE{giamarellosbourboulis2024pspi1928,
      author = {Giamarellos-Bourboulis, E.J.~ and Aschenbrenner, A.C.~ and Bauer, M.~ and Bock, C.~ and Calandra, T.~ and Gat-Viks, I.~ and Kyriazopoulou, E.~ and Lupse, M.~ and Monneret, G.~ and Pickkers, P.~ and Schultze, J.L.~ and van der Poll, T.~ and van de Veerdonk, F.L.~ and Vlaar, A.P.J.~ and Weis, S.~ and Wiersinga, W.J.~ and Netea, M.G.~},
      title = {The Pathophysiology of Sepsis and Precision-Medicine-Based Immunotherapy.},
      journal = {Nature Immunology},
      year = {2024},
      volume = {25},
      number = {1},
      pages = {19--28},
      issn = {1529-2916 1529-2908},
      doi = {10.1038/s41590-023-01660-5},
      keywords = {Humans;Biomarkers;Immunotherapy;*Precision Medicine;*Sepsis/therapy}
    }

2023

  • Fritsch S.D., Sukhbaatar N., Gonzales K., Sahu A., Tran L., Vogel A., Mazic M., Wilson J.L., Forisch S., Mayr H., Oberle R., Weiszmann J., Brenner M., Vanhoutte R., Hofmann M., Pirnes-Karhu S., Magnes C., Kühnast T., Weckwerth W., Bock C., Klavins K., Hengstschläger M., Moissl-Eichinger C., Schabbauer G., Egger G., Pirinen E., Verhelst S.H.L., Weichhart T.
    Metabolic Support by Macrophages Sustains Colonic Epithelial Homeostasis.
    Cell Metabolism 35(11), 1931–1943.e8, (2023) [bib]
    
    @ARTICLE{fritsch2023msbm19311943e8,
      author = {Fritsch, S.D.~ and Sukhbaatar, N.~ and Gonzales, K.~ and Sahu, A.~ and Tran, L.~ and Vogel, A.~ and Mazic, M.~ and Wilson, J.L.~ and Forisch, S.~ and Mayr, H.~ and Oberle, R.~ and Weiszmann, J.~ and Brenner, M.~ and Vanhoutte, R.~ and Hofmann, M.~ and Pirnes-Karhu, S.~ and Magnes, C.~ and K{\"u}hnast, T.~ and Weckwerth, W.~ and Bock, C.~ and Klavins, K.~ and Hengstschl{\"a}ger, M.~ and Moissl-Eichinger, C.~ and Schabbauer, G.~ and Egger, G.~ and Pirinen, E.~ and Verhelst, S.H.L.~ and Weichhart, T.~},
      title = {Metabolic Support by Macrophages Sustains Colonic Epithelial Homeostasis.},
      journal = {Cell Metabolism},
      year = {2023},
      volume = {35},
      number = {11},
      pages = {1931--1943.e8},
      issn = {1932-7420 1550-4131},
      doi = {10.1016/j.cmet.2023.09.010},
      keywords = {macrophages;arginase-1;homeostasis;immunometabolism;intestine;mTOR;mTORC1;polyamines;spermine}
    }
  • Brazdilova K., Redl A., Unterluggauer L., Kleissl L., Krausgruber T., Weichhart T., Bock C., Stary G.
    Mapping Single-Cell Trajectories upon mTOR Inhibition over Time in Patients with Granulomatous Disease.
    Journal of Investigative Dermatology 143(11, Suppl: Abstracts 5th Inflammatory Skin Disease Summit (ISDS), Vienna, Austria, 15–18 Nov 2023), S348, (2023) [bib]
    
    @ARTICLE{brazdilova2023mstus348s348,
      author = {Brazdilova, K.~ and Redl, A.~ and Unterluggauer, L.~ and Kleissl, L.~ and Krausgruber, T.~ and Weichhart, T.~ and Bock, C.~ and Stary, G.~},
      title = {Mapping Single-Cell Trajectories upon mTOR Inhibition over Time in Patients with Granulomatous Disease.},
      journal = {Journal of Investigative Dermatology},
      year = {2023},
      volume = {143},
      number = {11, Suppl: Abstracts 5th Inflammatory Skin Disease Summit (ISDS), Vienna, Austria, 15–18 Nov 2023},
      pages = {S348},
      issn = {0022-202X},
      url = {https://doi.org/10.1016/j.jid.2023.09.103}
    }
  • Harikumar N., Sharma V., Platzer R., Borik L., Pfisterer K., Petzelbauer P., Menche J., Hoeller C., Dupré L., Huppa J., Bock C., Stary G.
    Regulation of T Cell Functions by Cytoskeletal Proteins in the Melanoma Tumor Microenvironment.
    Journal of Investigative Dermatology 143(11, Suppl: Abstracts 5th Inflammatory Skin Disease Summit 2023, Vienna, Austria, 15–18 November 2023), S359, (2023) [bib]
    
    @ARTICLE{harikumar2023rtcfs359s359,
      author = {Harikumar, N.~ and Sharma, V.~ and Platzer, R.~ and Borik, L.~ and Pfisterer, K.~ and Petzelbauer, P.~ and Menche, J.~ and Hoeller, C.~ and Dupré, L.~ and Huppa, J.~ and Bock, C.~ and Stary, G.~},
      title = {Regulation of T Cell Functions by Cytoskeletal Proteins in the Melanoma Tumor Microenvironment.},
      journal = {Journal of Investigative Dermatology},
      year = {2023},
      volume = {143},
      number = {11, Suppl: Abstracts 5th Inflammatory Skin Disease Summit 2023, Vienna, Austria, 15–18 November 2023},
      pages = {S359},
      issn = {0022-202X},
      doi = {10.1016/j.jid.2023.09.167},
      url = {https://www.sciencedirect.com/science/article/pii/S0022202X2302763X}
    }
  • Redl A., Doberer K., Unterluggauer L., Krall C., Mayerhofer C., Kleissl L., Reininger B., Stary V., Zilla N., Weninger W., Weichhart T., Bock C., Krausgruber T., Stary G.
    Effectivity of mTOR Inhibition in Cutaneous Sarcoidosis.
    Journal of Investigative Dermatology 143(11, Suppl: Abstracts 5th Inflammatory Skin Disease Summit (ISDS), Vienna, Austria, 15–18 Nov 2023), S360, (2023) [bib]
    
    @ARTICLE{redl2023emics360s360,
      author = {Redl, A.~ and Doberer, K.~ and Unterluggauer, L.~ and Krall, C.~ and Mayerhofer, C.~ and Kleissl, L.~ and Reininger, B.~ and Stary, V.~ and Zilla, N.~ and Weninger, W.~ and Weichhart, T.~ and Bock, C.~ and Krausgruber, T.~ and Stary, G.~},
      title = {Effectivity of mTOR Inhibition in Cutaneous Sarcoidosis.},
      journal = {Journal of Investigative Dermatology},
      year = {2023},
      volume = {143},
      number = {11, Suppl: Abstracts 5th Inflammatory Skin Disease Summit (ISDS), Vienna, Austria, 15–18 Nov 2023},
      pages = {S360},
      issn = {0022-202X},
      url = {https://doi.org/10.1016/j.jid.2023.09.176}
    }
  • Nenning K.-H., Gesperger J., Furtner J., Nemc A., Roetzer-Pejrimovsky T., Choi S.-W., Mitter C., Leber S.L., Hofmanninger J., Klughammer J., Ergüner B., Bauer M., Brada M., Chong K., Brandner-Kokalj T., Freyschlag C.F., Grams A., Haybaeck J., Hoenigschnabl S., Hoffermann M., Iglseder S., Kiesel B., Kitzwoegerer M., Kleindienst W., Marhold F., Moser P., Oberndorfer S., Pinggera D., Scheichel F., Sherif C., Stockhammer G., Stultschnig M., Thomé C., Trenkler J., Urbanic-Purkart T., Weis S., Widhalm G., Wuertz F., Preusser M., Baumann B., Simonitsch-Klupp I., Nam D.-H., Bock C., Langs G., Woehrer A.
    Radiomic Features Define Risk and Are Linked to DNA Methylation Attributes in Primary CNS Lymphoma.
    Neuro-Oncology Advances 5:vdad136, (2023) [bib]
    
    @ARTICLE{nenning2023rfdrvdad136,
      author = {Nenning, K.-H.~ and Gesperger, J.~ and Furtner, J.~ and Nemc, A.~ and Roetzer-Pejrimovsky, T.~ and Choi, S.-W.~ and Mitter, C.~ and Leber, S.L.~ and Hofmanninger, J.~ and Klughammer, J.~ and Erg{\"u}ner, B.~ and Bauer, M.~ and Brada, M.~ and Chong, K.~ and Brandner-Kokalj, T.~ and Freyschlag, C.F.~ and Grams, A.~ and Haybaeck, J.~ and Hoenigschnabl, S.~ and Hoffermann, M.~ and Iglseder, S.~ and Kiesel, B.~ and Kitzwoegerer, M.~ and Kleindienst, W.~ and Marhold, F.~ and Moser, P.~ and Oberndorfer, S.~ and Pinggera, D.~ and Scheichel, F.~ and Sherif, C.~ and Stockhammer, G.~ and Stultschnig, M.~ and Thomé, C.~ and Trenkler, J.~ and Urbanic-Purkart, T.~ and Weis, S.~ and Widhalm, G.~ and Wuertz, F.~ and Preusser, M.~ and Baumann, B.~ and Simonitsch-Klupp, I.~ and Nam, D.-H.~ and Bock, C.~ and Langs, G.~ and Woehrer, A.~},
      title = {Radiomic Features Define Risk and Are Linked to DNA Methylation Attributes in Primary CNS Lymphoma.},
      journal = {Neuro-Oncology Advances},
      year = {2023},
      volume = {5},
      pages = {vdad136},
      issn = {2632-2498},
      doi = {10.1093/noajnl/vdad136},
      keywords = {survival;DNA methylation;primary CNS lymphoma;radiomics;risk score}
    }
  • Stolz V., Rica R., Zhu C., Freitas E., Preglej T., Hamminger P., Hainberger D., Alteneder M., Müller L., Agerer B., Schuster M., Frey T., Krausgruber T., Boucheron N., Knapp S., Schmetterer K., Trauner M., Bergthaler A., Bock C., Ellmeier W.
    NCOR1 Controls Treg Subset Differentiation and Effector Function.
    European Journal of Immunology 53(Suppl 2: Abstracts Joint Conference of the Société Française d’Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI), Strasbourg, France, 26–29 Sep 2023), 128, (2023) [bib]
    
    @ARTICLE{stolz2023ncts128128,
      author = {Stolz, V.~ and Rica, R.~ and Zhu, C.~ and Freitas, E.~ and Preglej, T.~ and Hamminger, P.~ and Hainberger, D.~ and Alteneder, M.~ and M{\"u}ller, L.~ and Agerer, B.~ and Schuster, M.~ and Frey, T.~ and Krausgruber, T.~ and Boucheron, N.~ and Knapp, S.~ and Schmetterer, K.~ and Trauner, M.~ and Bergthaler, A.~ and Bock, C.~ and Ellmeier, W.~},
      title = {NCOR1 Controls Treg Subset Differentiation and Effector Function.},
      journal = {European Journal of Immunology},
      year = {2023},
      volume = {53},
      number = {Suppl 2: Abstracts Joint Conference of the Société Française d’Immunologie (SFI) and the Deutsche Gesellschaft f{\"u}r Immunologie (DGfI), Strasbourg, France, 26–29 Sep 2023},
      pages = {128},
      issn = {0014-2980},
      doi = {DOI: 10.1002/eji.202370300},
      url = {https://onlinelibrary.wiley.com/toc/15214141/2023/53/S2}
    }
  • Kostel Bal S., Giuliani S., Block J., Repiscak P., Hafemeister C., Shahin T., Kasap N., Ransmayr B., Miao Y., van de Wetering C., Frohne A., Jimenez-Heredia R., Schuster M.K., Zoghi S., Hertlein V., Thian M., Bykov A., Babayeva R., Bilgic Eltan S., Karakoc-Aydiner E., Shaw L.E., Chowdury I., Varjosalo M., Argüello R.J., Farlik M., Ozen A., Serfling E.A.E., Dupré L., Bock C., Halbritter F., Hannich J.T., Castanon I., Kraakman M.J., Baris S., Boztug K.
    Biallelic NFATC1 Mutations Cause an Inborn Error of Immunity with Impaired CD8+ T-Cell Function and Perturbed Glycolysis.
    Blood 142(9), 827–845, (2023) [bib]
    
    @ARTICLE{kostelbal2023bnmc827845,
      author = {Kostel Bal, S.~ and Giuliani, S.~ and Block, J.~ and Repiscak, P.~ and Hafemeister, C.~ and Shahin, T.~ and Kasap, N.~ and Ransmayr, B.~ and Miao, Y.~ and van de Wetering, C.~ and Frohne, A.~ and Jimenez-Heredia, R.~ and Schuster, M.K.~ and Zoghi, S.~ and Hertlein, V.~ and Thian, M.~ and Bykov, A.~ and Babayeva, R.~ and Bilgic Eltan, S.~ and Karakoc-Aydiner, E.~ and Shaw, L.E.~ and Chowdury, I.~ and Varjosalo, M.~ and Arg{\"u}ello, R.J.~ and Farlik, M.~ and Ozen, A.~ and Serfling, E.A.E.~ and Dupré, L.~ and Bock, C.~ and Halbritter, F.~ and Hannich, J.T.~ and Castanon, I.~ and Kraakman, M.J.~ and Baris, S.~ and Boztug, K.~},
      title = {Biallelic NFATC1 Mutations Cause an Inborn Error of Immunity with Impaired CD8+ T-Cell Function and Perturbed Glycolysis.},
      journal = {Blood},
      year = {2023},
      volume = {142},
      number = {9},
      pages = {827--845},
      issn = {0006-4971},
      doi = {10.1182/blood.2022018303},
      url = {https://doi.org/10.1182/blood.2022018303}
    }
  • Enders L., Siklos M., Borggräfe J., Gaussmann S., Koren A., Malik M., Tomek T., Schuster M., Reiniš J., Hahn E., Rukavina A., Reicher A., Casteels T., Bock C., Winter G.E., Hannich J.T., Sattler M., Kubicek S.
    Pharmacological Perturbation of the Phase-Separating Protein SMNDC1.
    Nature Communications 14:4504, (2023) [bib]
    
    @ARTICLE{enders2023pppp4504,
      author = {Enders, L.~ and Siklos, M.~ and Borggr{\"a}fe, J.~ and Gaussmann, S.~ and Koren, A.~ and Malik, M.~ and Tomek, T.~ and Schuster, M.~ and Reiniš, J.~ and Hahn, E.~ and Rukavina, A.~ and Reicher, A.~ and Casteels, T.~ and Bock, C.~ and Winter, G.E.~ and Hannich, J.T.~ and Sattler, M.~ and Kubicek, S.~},
      title = {Pharmacological Perturbation of the Phase-Separating Protein SMNDC1.},
      journal = {Nature Communications},
      year = {2023},
      volume = {14},
      pages = {4504},
      issn = {2041-1723},
      doi = {10.1038/s41467-023-40124-0}
    }
  • Khan M., Alteneder M., Reiter W., Krausgruber T., Dobnikar L., Madern M., Waldherr M., Bock C., Hartl M., Ellmeier W., Henriksson J., Boucheron N.
    Single-Cell Profiling Uncovers Regulatory Programs of Pathogenic Th2 Cells in Allergic Asthma.
    bioRxiv 2023.08.10.552772, (2023) [bib]
    
    @ARTICLE{khan2023spur20230810552772,
      author = {Khan, M.~ and Alteneder, M.~ and Reiter, W.~ and Krausgruber, T.~ and Dobnikar, L.~ and Madern, M.~ and Waldherr, M.~ and Bock, C.~ and Hartl, M.~ and Ellmeier, W.~ and Henriksson, J.~ and Boucheron, N.~},
      title = {Single-Cell Profiling Uncovers Regulatory Programs of Pathogenic Th2 Cells in Allergic Asthma.},
      journal = {bioRxiv},
      year = {2023},
      pages = {2023.08.10.552772},
      doi = {10.1101/2023.08.10.552772}
    }
  • Block J., Rashkova C., Castanon I., Zoghi S., Platon J., Ardy R.C., Fujiwara M., Chaves B., Schoppmeyer R., van der Made C.I., Jimenez Heredia R., Harms F.L., Alavi S., Alsina L., Sanchez Moreno P., Ávila Polo R., Cabrera-Pérez R., Kostel Bal S., Pfajfer L., Ransmayr B., Mautner A.-K., Kondo R., Tinnacher A., Caldera M., Schuster M., Domínguez Conde C., Platzer R., Salzer E., Boyer T., Brunner H.G., Nooitgedagt-Frons J.E., Iglesias E., Deyà-Martinez A., Camacho-Lovillo M., Menche J., Bock C., Huppa J.B., Pickl W.F., Distel M., Yoder J.A., Traver D., Engelhardt K.R., Linden T., Kager L., Hannich J.T., Hoischen A., Hambleton S., Illsinger S., Da Costa L., Kutsche K., Chavoshzadeh Z., van Buul J.D., Antón J., Calzada-Hernández J., Neth O., Viaud J., Nishikimi A., Dupré L., Boztug K.
    Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
    New England Journal of Medicine 389(6), 527–539, (2023) [bib]
    
    @ARTICLE{block2023sina527539,
      author = {Block, J.~ and Rashkova, C.~ and Castanon, I.~ and Zoghi, S.~ and Platon, J.~ and Ardy, R.C.~ and Fujiwara, M.~ and Chaves, B.~ and Schoppmeyer, R.~ and van der Made, C.I.~ and Jimenez Heredia, R.~ and Harms, F.L.~ and Alavi, S.~ and Alsina, L.~ and Sanchez Moreno, P.~ and Ávila Polo, R.~ and Cabrera-Pérez, R.~ and Kostel Bal, S.~ and Pfajfer, L.~ and Ransmayr, B.~ and Mautner, A.-K.~ and Kondo, R.~ and Tinnacher, A.~ and Caldera, M.~ and Schuster, M.~ and Domínguez Conde, C.~ and Platzer, R.~ and Salzer, E.~ and Boyer, T.~ and Brunner, H.G.~ and Nooitgedagt-Frons, J.E.~ and Iglesias, E.~ and Deyà-Martinez, A.~ and Camacho-Lovillo, M.~ and Menche, J.~ and Bock, C.~ and Huppa, J.B.~ and Pickl, W.F.~ and Distel, M.~ and Yoder, J.A.~ and Traver, D.~ and Engelhardt, K.R.~ and Linden, T.~ and Kager, L.~ and Hannich, J.T.~ and Hoischen, A.~ and Hambleton, S.~ and Illsinger, S.~ and Da Costa, L.~ and Kutsche, K.~ and Chavoshzadeh, Z.~ and van Buul, J.D.~ and Antón, J.~ and Calzada-Hernández, J.~ and Neth, O.~ and Viaud, J.~ and Nishikimi, A.~ and Dupré, L.~ and Boztug, K.~},
      title = {Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.},
      journal = {New England Journal of Medicine},
      year = {2023},
      volume = {389},
      number = {6},
      pages = {527--539},
      issn = {1533-4406 0028-4793},
      doi = {10.1056/NEJMoa2210054}
    }
  • Kiss M.G., Papac-Milicevic N., Porsch F., Tsiantoulas D., Hendrikx T., Takaoka M., Dinh H.Q., Narzt M.-S., Goderle L., Ozsvar-Kozma M., Schuster M., Fortelny N., Hladik A., Knapp S., Gruber F., Pickering M.C., Bock C., Swirski F.K., Ley K., Zernecke A., Cochain C., Kemper C., Mallat Z., Binder C.J.
    Cell-Autonomous Regulation of Complement C3 by Factor H Limits Macrophage Efferocytosis and Exacerbates Atherosclerosis.
    Immunity 56(8), 1809–1824.e10, (2023) [bib]
    
    @ARTICLE{kiss2023crcc18091824e10,
      author = {Kiss, M.G.~ and Papac-Milicevic, N.~ and Porsch, F.~ and Tsiantoulas, D.~ and Hendrikx, T.~ and Takaoka, M.~ and Dinh, H.Q.~ and Narzt, M.-S.~ and Goderle, L.~ and Ozsvar-Kozma, M.~ and Schuster, M.~ and Fortelny, N.~ and Hladik, A.~ and Knapp, S.~ and Gruber, F.~ and Pickering, M.C.~ and Bock, C.~ and Swirski, F.K.~ and Ley, K.~ and Zernecke, A.~ and Cochain, C.~ and Kemper, C.~ and Mallat, Z.~ and Binder, C.J.~},
      title = {Cell-Autonomous Regulation of Complement C3 by Factor H Limits Macrophage Efferocytosis and Exacerbates Atherosclerosis.},
      journal = {Immunity},
      year = {2023},
      volume = {56},
      number = {8},
      pages = {1809--1824.e10},
      doi = {10.1016/j.immuni.2023.06.026}
    }
  • Fetahu I.S., Esser-Skala W., Dnyansagar R., Sindelar S., Rifatbegovic F., Bileck A., Skos L., Bozsaky E., Lazic D., Shaw L., Tötzl M., Tarlungeanu D., Bernkopf M., Rados M., Weninger W., Tomazou E.M., Bock C., Gerner C., Ladenstein R., Farlik M., Fortelny N., Taschner-Mandl S.
    Single-Cell Transcriptomics and Epigenomics Unravel the Role of Monocytes in Neuroblastoma Bone Marrow Metastasis.
    Nature Communications 14:3620, (2023) [bib]
    
    @ARTICLE{fetahu2023steu3620,
      author = {Fetahu, I.S.~ and Esser-Skala, W.~ and Dnyansagar, R.~ and Sindelar, S.~ and Rifatbegovic, F.~ and Bileck, A.~ and Skos, L.~ and Bozsaky, E.~ and Lazic, D.~ and Shaw, L.~ and T{\"o}tzl, M.~ and Tarlungeanu, D.~ and Bernkopf, M.~ and Rados, M.~ and Weninger, W.~ and Tomazou, E.M.~ and Bock, C.~ and Gerner, C.~ and Ladenstein, R.~ and Farlik, M.~ and Fortelny, N.~ and Taschner-Mandl, S.~},
      title = {Single-Cell Transcriptomics and Epigenomics Unravel the Role of Monocytes in Neuroblastoma Bone Marrow Metastasis.},
      journal = {Nature Communications},
      year = {2023},
      volume = {14},
      pages = {3620},
      issn = {2041-1723},
      doi = {10.1038/s41467-023-39210-0},
      keywords = {Humans;Child;Transcriptome;Bone Marrow/pathology;*Bone Marrow Neoplasms/genetics/metabolism/pathology;*Neuroblastoma/metabolism;Epigenomics;Monocytes/metabolism;Tumor Microenvironment/genetics}
    }
  • Chung F.F.-L., Maldonado S.G., Nemc A., Bouaoun L., Cahais V., Cuenin C., Salle A., Johnson T., Erguner B., Laplana M., Datlinger P., Jeschke J., Weiderpass E., Kristensen V., Delaloge S., Fuks F., Risch A., Ghantous A., Plass C., Bock C., Kaaks R., Herceg Z.
    Buffy Coat Signatures of Breast Cancer Risk in a Prospective Cohort Study.
    Clinical Epigenetics 15:102, (2023) [bib]
    
    @ARTICLE{chung2023bcsb102,
      author = {Chung, F.F.-L.~ and Maldonado, S.G.~ and Nemc, A.~ and Bouaoun, L.~ and Cahais, V.~ and Cuenin, C.~ and Salle, A.~ and Johnson, T.~ and Erguner, B.~ and Laplana, M.~ and Datlinger, P.~ and Jeschke, J.~ and Weiderpass, E.~ and Kristensen, V.~ and Delaloge, S.~ and Fuks, F.~ and Risch, A.~ and Ghantous, A.~ and Plass, C.~ and Bock, C.~ and Kaaks, R.~ and Herceg, Z.~},
      title = {Buffy Coat Signatures of Breast Cancer Risk in a Prospective Cohort Study.},
      journal = {Clinical Epigenetics},
      year = {2023},
      volume = {15},
      pages = {102},
      doi = {10.1186/s13148-023-01509-6}
    }
  • Redl A., Krausgruber T., Barreca D., Lim C., Doberer K., Unterluggauer L., Kleissl L., Mayerhofer C., Kopf A., Weichhart T., Bock C., Stary G.
    Single-Cell and Spatial Architecture of Human Tissue Granulomas Reveals an Aberrant Immune-Regulatory Program Underlying Sarcoidosis.
    Journal of Investigative Dermatology 143(5, Suppl: Abstracts 1st International Societies for Investigative Dermatology Meeting (ISID 2023), Tokyo, Japan, 12–13 May 2023), S172, (2023) [bib]
    
    @ARTICLE{redl2023ssahs172s172,
      author = {Redl, A.~ and Krausgruber, T.~ and Barreca, D.~ and Lim, C.~ and Doberer, K.~ and Unterluggauer, L.~ and Kleissl, L.~ and Mayerhofer, C.~ and Kopf, A.~ and Weichhart, T.~ and Bock, C.~ and Stary, G.~},
      title = {Single-Cell and Spatial Architecture of Human Tissue Granulomas Reveals an Aberrant Immune-Regulatory Program Underlying Sarcoidosis.},
      journal = {Journal of Investigative Dermatology},
      year = {2023},
      volume = {143},
      number = {5, Suppl: Abstracts 1st International Societies for Investigative Dermatology Meeting (ISID 2023), Tokyo, Japan, 12–13 May 2023},
      pages = {S172},
      issn = {0022-202X},
      url = {https://www.jidonline.org/article/S0022-202X(23)01192-2/fulltext}
    }
  • Zhu C., Stolz V., Simonovic N., Al-Rubaye O., Vcelkova T., Moos V., Hess L., Hagelkrueys A., Madern M., Reiter W., Meixner A., Bock C., Hartl M., Ellmeier W., Seiser C.
    Targeting the Catalytic Activity of HDAC1 in T Cells Protects against Experimental Autoimmune Encephalomyelitis.
    bioRxiv 2023.04.14.536700, (2023) [bib]
    
    @ARTICLE{zhu2023tcah20230414536700,
      author = {Zhu, C.~ and Stolz, V.~ and Simonovic, N.~ and Al-Rubaye, O.~ and Vcelkova, T.~ and Moos, V.~ and Hess, L.~ and Hagelkrueys, A.~ and Madern, M.~ and Reiter, W.~ and Meixner, A.~ and Bock, C.~ and Hartl, M.~ and Ellmeier, W.~ and Seiser, C.~},
      title = {Targeting the Catalytic Activity of HDAC1 in T Cells Protects against Experimental Autoimmune Encephalomyelitis.},
      journal = {bioRxiv},
      year = {2023},
      pages = {2023.04.14.536700},
      doi = {10.1101/2023.04.14.536700}
    }
  • Farlik M., Halbritter F., Schwentner R., Jug G., Fortelny N., Schnoller T., Pisa H., Schuster L., Reinprecht A., Czech T., Gojo J., Holter W., Minkov M., Bauer W., Simonitsch-Klupp I., Bock C., Hutter C.
    Epigenomics and Single-Cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis.
    Experimental Dermatology 32(4, Abstracts Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF) (cancelled), Berlin, Germany, 11–14 March 2020), e102, (2023) [bib]
    
    @ARTICLE{farlik2023essde102e102,
      author = {Farlik, M.~ and Halbritter, F.~ and Schwentner, R.~ and Jug, G.~ and Fortelny, N.~ and Schnoller, T.~ and Pisa, H.~ and Schuster, L.~ and Reinprecht, A.~ and Czech, T.~ and Gojo, J.~ and Holter, W.~ and Minkov, M.~ and Bauer, W.~ and Simonitsch-Klupp, I.~ and Bock, C.~ and Hutter, C.~},
      title = {Epigenomics and Single-Cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis.},
      journal = {Experimental Dermatology},
      year = {2023},
      volume = {32},
      number = {4, Abstracts Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF) (cancelled), Berlin, Germany, 11–14 March 2020},
      pages = {e102},
      issn = {0906-6705},
      url = {https://onlinelibrary.wiley.com/doi/10.1111/exd.14067}
    }
  • Akbar N., Braithwaite A.T., Corr E.M., Koelwyn G.J., van Solingen C., Cochain C., Saliba A.-E., Corbin A., Pezzolla D., Møller Jørgensen M., Bæk R., Edgar L., De Villiers C., Gunadasa-Rohling M., Banerjee A., Paget D., Lee C., Hogg E., Costin A., Dhaliwal R., Johnson E., Krausgruber T., Riepsaame J., Melling G.E., Shanmuganathan M., Bock C., Carter D.R.F., Channon K.M., Riley P.R., Udalova I.A., Moore K.J., Anthony D.C., Choudhury R.P.
    Rapid Neutrophil Mobilization by VCAM-1+ Endothelial Cell-Derived Extracellular Vesicles.
    Cardiovascular Research 119(1), 236–251, (2023) [bib]
    
    @ARTICLE{akbar2023rnmb236251,
      author = {Akbar, N.~ and Braithwaite, A.T.~ and Corr, E.M.~ and Koelwyn, G.J.~ and van Solingen, C.~ and Cochain, C.~ and Saliba, A.-E.~ and Corbin, A.~ and Pezzolla, D.~ and Møller Jørgensen, M.~ and Bæk, R.~ and Edgar, L.~ and De Villiers, C.~ and Gunadasa-Rohling, M.~ and Banerjee, A.~ and Paget, D.~ and Lee, C.~ and Hogg, E.~ and Costin, A.~ and Dhaliwal, R.~ and Johnson, E.~ and Krausgruber, T.~ and Riepsaame, J.~ and Melling, G.E.~ and Shanmuganathan, M.~ and Bock, C.~ and Carter, D.R.F.~ and Channon, K.M.~ and Riley, P.R.~ and Udalova, I.A.~ and Moore, K.J.~ and Anthony, D.C.~ and Choudhury, R.P.~},
      title = {Rapid Neutrophil Mobilization by VCAM-1+ Endothelial Cell-Derived Extracellular Vesicles.},
      journal = {Cardiovascular Research},
      year = {2023},
      volume = {119},
      number = {1},
      pages = {236--251},
      issn = {1755-3245 0008-6363},
      doi = {10.1093/cvr/cvac012},
      keywords = {Animals;Mice;Myocardial infarction;*Extracellular Vesicles/metabolism;*MicroRNAs/genetics/metabolism;*Myocardial Infarction/metabolism;Endothelial Cells/metabolism;Exosome;Neutrophils/metabolism;Programming;Spleen;Vascular Cell Adhesion Molecule-1/genetics/metabolism}
    }
  • Pandey R.V., Strobl J., Redl A., Unterluggauer L., Gail L., Kleissl L., Müller S., Atzmüller D., Fife-Gernedl V., Krausgruber T., Knaus H., Mitterbauer M., Wohlfarth P., Rabitsch W., Bock C., Stary G.
    Epigenetic Regulation of T Cell Lineages in Skin and Blood Following Hematopoietic Stem Cell Transplantation.
    Clinical Immunology 248:109245, (2023) [bib]
    
    @ARTICLE{pandey2023ertc109245,
      author = {Pandey, R.V.~ and Strobl, J.~ and Redl, A.~ and Unterluggauer, L.~ and Gail, L.~ and Kleissl, L.~ and M{\"u}ller, S.~ and Atzm{\"u}ller, D.~ and Fife-Gernedl, V.~ and Krausgruber, T.~ and Knaus, H.~ and Mitterbauer, M.~ and Wohlfarth, P.~ and Rabitsch, W.~ and Bock, C.~ and Stary, G.~},
      title = {Epigenetic Regulation of T Cell Lineages in Skin and Blood Following Hematopoietic Stem Cell Transplantation.},
      journal = {Clinical Immunology},
      year = {2023},
      volume = {248},
      pages = {109245},
      issn = {1521-7035 1521-6616},
      doi = {10.1016/j.clim.2023.109245},
      keywords = {T cells;Histone deacetylases;Epigenetic regulation;Hematopoietic stem cell transplantation}
    }
  • Krausgruber T., Redl A., Barreca D., Doberer K., Romanovskaia D., Dobnikar L., Guarini M., Unterluggauer L., Kleissl L., Atzmuller D., Mayerhofer C., Kopf A., Saluzzo S., Lim C.X., Rexie P., Weichhart T., Bock C., Stary G.
    Single-Cell and Spatial Transcriptomics Reveal Aberrant Lymphoid Developmental Programs Driving Granuloma Formation.
    Immunity 56(2), 289–306.e7, (2023) [bib]
    
    @ARTICLE{krausgruber2023sstr289306e7,
      author = {Krausgruber, T.~ and Redl, A.~ and Barreca, D.~ and Doberer, K.~ and Romanovskaia, D.~ and Dobnikar, L.~ and Guarini, M.~ and Unterluggauer, L.~ and Kleissl, L.~ and Atzmuller, D.~ and Mayerhofer, C.~ and Kopf, A.~ and Saluzzo, S.~ and Lim, C.X.~ and Rexie, P.~ and Weichhart, T.~ and Bock, C.~ and Stary, G.~},
      title = {Single-Cell and Spatial Transcriptomics Reveal Aberrant Lymphoid Developmental Programs Driving Granuloma Formation.},
      journal = {Immunity},
      year = {2023},
      volume = {56},
      number = {2},
      pages = {289--306.e7},
      doi = {10.1016/j.immuni.2023.01.014}
    }
  • Pototschnig I., Feiler U., Diwoky C., Vesely P.W., Rauchenwald T., Paar M., Bakiri L., Pajed L., Hofer P., Kashofer K., Sukhbaatar N., Schoiswohl G., Weichhart T., Hoefler G., Bock C., Pichler M., Wagner E.F., Zechner R., Schweiger M.
    Interleukin-6 Initiates Muscle- and Adipose Tissue Wasting in a Novel C57BL/6 Model of Cancer-Associated Cachexia.
    Journal of Cachexia, Sarcopenia and Muscle 14(1), 93–107, (2023) [bib]
    
    @ARTICLE{pototschnig2023iima93107,
      author = {Pototschnig, I.~ and Feiler, U.~ and Diwoky, C.~ and Vesely, P.W.~ and Rauchenwald, T.~ and Paar, M.~ and Bakiri, L.~ and Pajed, L.~ and Hofer, P.~ and Kashofer, K.~ and Sukhbaatar, N.~ and Schoiswohl, G.~ and Weichhart, T.~ and Hoefler, G.~ and Bock, C.~ and Pichler, M.~ and Wagner, E.F.~ and Zechner, R.~ and Schweiger, M.~},
      title = {Interleukin-6 Initiates Muscle- and Adipose Tissue Wasting in a Novel C57BL/6 Model of Cancer-Associated Cachexia.},
      journal = {Journal of Cachexia, Sarcopenia and Muscle},
      year = {2023},
      volume = {14},
      number = {1},
      pages = {93--107},
      issn = {2190-6009 2190-5991},
      doi = {10.1002/jcsm.13109},
      keywords = {Cancer;Adipose tissue;C57BL/6;Cachexia;Interleukin-6}
    }
  • Klughammer J., Romanovskaia D., Nemc A., Posautz A., Seid C.A., Schuster L.C., Keinath M.C., Lugo Ramos J.S., Kosack L., Evankow A., Printz D., Kirchberger S., Erguner B., Datlinger P., Fortelny N., Schmidl C., Farlik M., Skjarven K., Bergthaler A., Liedvogel M., Thaller D., Burger P.A., Hermann M., Distel M., Distel D.L., Kubber-Heiss A., Bock C.
    Comparative Analysis of Genome-Scale, Base-Resolution DNA Methylation Profiles across 580 Animal Species.
    Nature Communications 14:232, (2023) [bib]
    
    @ARTICLE{klughammer2023cagb232,
      author = {Klughammer, J.~ and Romanovskaia, D.~ and Nemc, A.~ and Posautz, A.~ and Seid, C.A.~ and Schuster, L.C.~ and Keinath, M.C.~ and Lugo Ramos, J.S.~ and Kosack, L.~ and Evankow, A.~ and Printz, D.~ and Kirchberger, S.~ and Erguner, B.~ and Datlinger, P.~ and Fortelny, N.~ and Schmidl, C.~ and Farlik, M.~ and Skjarven, K.~ and Bergthaler, A.~ and Liedvogel, M.~ and Thaller, D.~ and Burger, P.A.~ and Hermann, M.~ and Distel, M.~ and Distel, D.L.~ and Kubber-Heiss, A.~ and Bock, C.~},
      title = {Comparative Analysis of Genome-Scale, Base-Resolution DNA Methylation Profiles across 580 Animal Species.},
      journal = {Nature Communications},
      year = {2023},
      volume = {14},
      pages = {232},
      doi = {10.1038/s41467-022-34828-y}
    }

2022

  • Vos W.A.J.W., Groenendijk A.L., Blaauw M.J.T., van Eekeren L.E., Navas A., Cleophas M.C.P., Vadaq N., Matzaraki V., Dos Santos J.C., Meeder E.M.G., Fröberg J., Weijers G., Zhang Y., Fu J., Ter Horst R., Bock C., Knoll R., Aschenbrenner A.C., Schultze J., Vanderkerckhove L., Hwandih T., Wonderlich E.R., Vemula S.V., van der Kolk M., de Vet S.C.P., Blok W.L., Brinkman K., Rokx C., Schellekens A.F.A., de Mast Q., Joosten L.A.B., Berrevoets M.A.H., Stalenhoef J.E., Verbon A., van Lunzen J., Netea M.G., van der Ven A.J.A.M.
    The 2000HIV Study: Design, Multi-Omics Methods and Participant Characteristics.
    Frontiers in Immunology 13:982746, (2022) [bib]
    
    @ARTICLE{vos20222sdm982746,
      author = {Vos, W.A.J.W.~ and Groenendijk, A.L.~ and Blaauw, M.J.T.~ and van Eekeren, L.E.~ and Navas, A.~ and Cleophas, M.C.P.~ and Vadaq, N.~ and Matzaraki, V.~ and Dos Santos, J.C.~ and Meeder, E.M.G.~ and Fr{\"o}berg, J.~ and Weijers, G.~ and Zhang, Y.~ and Fu, J.~ and Ter Horst, R.~ and Bock, C.~ and Knoll, R.~ and Aschenbrenner, A.C.~ and Schultze, J.~ and Vanderkerckhove, L.~ and Hwandih, T.~ and Wonderlich, E.R.~ and Vemula, S.V.~ and van der Kolk, M.~ and de Vet, S.C.P.~ and Blok, W.L.~ and Brinkman, K.~ and Rokx, C.~ and Schellekens, A.F.A.~ and de Mast, Q.~ and Joosten, L.A.B.~ and Berrevoets, M.A.H.~ and Stalenhoef, J.E.~ and Verbon, A.~ and van Lunzen, J.~ and Netea, M.G.~ and van der Ven, A.J.A.M.~},
      title = {The 2000HIV Study: Design, Multi-Omics Methods and Participant Characteristics.},
      journal = {Frontiers in Immunology},
      year = {2022},
      volume = {13},
      pages = {982746},
      issn = {1664-3224},
      doi = {10.3389/fimmu.2022.982746},
      keywords = {COVID-19;HIV-1;cardiovascular disease;hepatic disease;HIV extreme phenotype;HIV reservoir;multi-omics;non-AIDS comorbidities}
    }
  • Boccuni L., Podgorschek E., Schmiedeberg M., Platanitis E., Traxler P., Fischer P., Schirripa A., Novoszel P., Nebreda A.R., Arthur J.S.C., Fortelny N., Farlik M., Sexl V., Bock C., Sibilia M., Kovarik P., Muller M., Decker T.
    Stress Signaling Boosts Interferon-Induced Gene Transcription in Macrophages.
    Science Signaling 15(764):eabq5389, (2022) [bib]
    
    @ARTICLE{boccuni2022ssbieabq5389,
      author = {Boccuni, L.~ and Podgorschek, E.~ and Schmiedeberg, M.~ and Platanitis, E.~ and Traxler, P.~ and Fischer, P.~ and Schirripa, A.~ and Novoszel, P.~ and Nebreda, A.R.~ and Arthur, J.S.C.~ and Fortelny, N.~ and Farlik, M.~ and Sexl, V.~ and Bock, C.~ and Sibilia, M.~ and Kovarik, P.~ and Muller, M.~ and Decker, T.~},
      title = {Stress Signaling Boosts Interferon-Induced Gene Transcription in Macrophages.},
      journal = {Science Signaling},
      year = {2022},
      volume = {15},
      number = {764},
      pages = {eabq5389},
      doi = {10.1126/scisignal.abq5389}
    }
  • Amman F., Markt R., Endler L., Hupfauf S., Agerer B., Schedl A., Richter L., Zechmeister M., Bicher M., Heiler G., Triska P., Thornton M., Penz T., Senekowitsch M., Laine J., Keszei Z., Klimek P., Nagele F., Mayr M., Daleiden B., Steinlechner M., Niederstatter H., Heidinger P., Rauch W., Scheffknecht C., Vogl G., Weichlinger G., Wagner A.O., Slipko K., Masseron A., Radu E., Allerberger F., Popper N., Bock C., Schmid D., Oberacher H., Kreuzinger N., Insam H., Bergthaler A.
    Viral Variant-Resolved Wastewater Surveillance of SARS-CoV-2 at National Scale.
    Nature Biotechnology 40(12), 1814–1822, (2022) [bib]
    
    @ARTICLE{amman2022vvws18141822,
      author = {Amman, F.~ and Markt, R.~ and Endler, L.~ and Hupfauf, S.~ and Agerer, B.~ and Schedl, A.~ and Richter, L.~ and Zechmeister, M.~ and Bicher, M.~ and Heiler, G.~ and Triska, P.~ and Thornton, M.~ and Penz, T.~ and Senekowitsch, M.~ and Laine, J.~ and Keszei, Z.~ and Klimek, P.~ and Nagele, F.~ and Mayr, M.~ and Daleiden, B.~ and Steinlechner, M.~ and Niederstatter, H.~ and Heidinger, P.~ and Rauch, W.~ and Scheffknecht, C.~ and Vogl, G.~ and Weichlinger, G.~ and Wagner, A.O.~ and Slipko, K.~ and Masseron, A.~ and Radu, E.~ and Allerberger, F.~ and Popper, N.~ and Bock, C.~ and Schmid, D.~ and Oberacher, H.~ and Kreuzinger, N.~ and Insam, H.~ and Bergthaler, A.~},
      title = {Viral Variant-Resolved Wastewater Surveillance of SARS-CoV-2 at National Scale.},
      journal = {Nature Biotechnology},
      year = {2022},
      volume = {40},
      number = {12},
      pages = {1814--1822},
      doi = {10.1038/s41587-022-01387-y}
    }
  • Bock C., Datlinger P., Chardon F., Coelho M.A., Dong M.B., Lawson K.A., Lu T., Maroc L., Norman T.M., Song B., Stanley G., Chen S., Garnett M., Li W., Moffat J., Qi L.S., Shapiro R.S., Shendure J., Weissman J.S., Zhuang X.
    High-Content CRISPR Screening.
    Nature Reviews Methods Primers 2:8, (2022) [bib]
    
    @ARTICLE{bock2022hcs8,
      author = {Bock, C.~ and Datlinger, P.~ and Chardon, F.~ and Coelho, M.A.~ and Dong, M.B.~ and Lawson, K.A.~ and Lu, T.~ and Maroc, L.~ and Norman, T.M.~ and Song, B.~ and Stanley, G.~ and Chen, S.~ and Garnett, M.~ and Li, W.~ and Moffat, J.~ and Qi, L.S.~ and Shapiro, R.S.~ and Shendure, J.~ and Weissman, J.S.~ and Zhuang, X.~},
      title = {High-Content CRISPR Screening.},
      journal = {Nature Reviews Methods Primers},
      year = {2022},
      volume = {2},
      pages = {8},
      doi = {10.1038/s43586-021-00093-4},
      url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85130264697\&doi=10.1038%2fs43586-021-00093-4\&partnerID=40\&md5=015e1e149e06c31cdc34c07e6a38ec48}
    }
  • Seyres D., Cabassi A., Lambourne J.J., Burden F., Farrow S., McKinney H., Batista J., Kempster C., Pietzner M., Slingsby O., Cao T.H., Quinn P.A., Stefanucci L., Sims M.C., Rehnstrom K., Adams C.L., Frary A., Erguener B., Kreuzhuber R., Mocciaro G., D´Amore S., Koulman A., Grassi L., Griffin J.L., Ng L.L., Park A., Savage D.B., Langenberg C., Bock C., Downes K., Wareham N.J., Allison M., Vacca M., Kirk P.D.W., Frontini M.
    Transcriptional, Epigenetic and Metabolic Signatures in Cardiometabolic Syndrome Defined by Extreme Phenotypes.
    Clinical Epigenetics 14:39, (2022) [bib]
    
    @ARTICLE{seyres2022tems39,
      author = {Seyres, D.~ and Cabassi, A.~ and Lambourne, J.J.~ and Burden, F.~ and Farrow, S.~ and McKinney, H.~ and Batista, J.~ and Kempster, C.~ and Pietzner, M.~ and Slingsby, O.~ and Cao, T.H.~ and Quinn, P.A.~ and Stefanucci, L.~ and Sims, M.C.~ and Rehnstrom, K.~ and Adams, C.L.~ and Frary, A.~ and Erguener, B.~ and Kreuzhuber, R.~ and Mocciaro, G.~ and D´Amore, S.~ and Koulman, A.~ and Grassi, L.~ and Griffin, J.L.~ and Ng, L.L.~ and Park, A.~ and Savage, D.B.~ and Langenberg, C.~ and Bock, C.~ and Downes, K.~ and Wareham, N.J.~ and Allison, M.~ and Vacca, M.~ and Kirk, P.D.W.~ and Frontini, M.~},
      title = {Transcriptional, Epigenetic and Metabolic Signatures in Cardiometabolic Syndrome Defined by Extreme Phenotypes.},
      journal = {Clinical Epigenetics},
      year = {2022},
      volume = {14},
      pages = {39},
      issn = {1868-7083},
      doi = {10.1186/s13148-022-01257-z}
    }
  • Roetzer-Pejrimovsky T., Kiesel B., Nenning K., Klughammer J., Rajchl M., Bock C., Hainfellner J., Baumann B., Langs G., Woehrer A.
    Linking Histological Glioblastoma Phenotypes to Transcriptional Subtypes and Prognosis Using Deep Learning.
    Neuro-Oncology 24(Suppl 7: Abstracts 27th Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO), Tampa, FL, 16–20 November 2022), vii118–vii119, (2022) [bib]
    
    @ARTICLE{roetzerpejrimovsky2022lhgpvii118vii119,
      author = {Roetzer-Pejrimovsky, T.~ and Kiesel, B.~ and Nenning, K.~ and Klughammer, J.~ and Rajchl, M.~ and Bock, C.~ and Hainfellner, J.~ and Baumann, B.~ and Langs, G.~ and Woehrer, A.~},
      title = {Linking Histological Glioblastoma Phenotypes to Transcriptional Subtypes and Prognosis Using Deep Learning.},
      journal = {Neuro-Oncology},
      year = {2022},
      volume = {24},
      number = {Suppl 7: Abstracts 27th Annual Scientific Meeting and Education Day of the Society-for-Neuro-Oncology (SNO), Tampa, FL, 16–20 November 2022},
      pages = {vii118--vii119},
      issn = {1522-8517},
      doi = {10.1093/neuonc/noac209.450}
    }
  • Gogolou A., Souilhol C., Granata I., Wymeersch F.J., Manipur I., Wind M., Frith T.J.R., Guarini M., Bertero A., Bock C., Halbritter F., Takasato M., Guarracino M.R., Tsakiridis A.
    Early Anteroposterior Regionalisation of Human Neural Crest Is Shaped by a Pro-Mesodermal Factor.
    eLife 11:e74263, (2022) [bib]
    
    @ARTICLE{gogolou2022earhe74263,
      author = {Gogolou, A.~ and Souilhol, C.~ and Granata, I.~ and Wymeersch, F.J.~ and Manipur, I.~ and Wind, M.~ and Frith, T.J.R.~ and Guarini, M.~ and Bertero, A.~ and Bock, C.~ and Halbritter, F.~ and Takasato, M.~ and Guarracino, M.R.~ and Tsakiridis, A.~},
      title = {Early Anteroposterior Regionalisation of Human Neural Crest Is Shaped by a Pro-Mesodermal Factor.},
      journal = {eLife},
      year = {2022},
      volume = {11},
      pages = {e74263},
      issn = {2050-084X},
      doi = {10.7554/eLife.74263},
      keywords = {human;developmental biology;mouse;regenerative medicine;stem cells}
    }
  • Kivinen K., van Luenen H.G., Alcalay M., Bock C., Dodzian J., Hoskova K., Hoyle D., Hradil O., Christensen S.K., Korn B., Kosteas T., Morales M., Skowronek K., Theodorou V., Van Minnebruggen G., Salamero J., Premvardhan L.
    Acknowledging and Citing Core Facilities: Key Contributions to Data Lifecycle Should Be Recognised in the Scientific Literature.
    EMBO Reports 23(9):e55734, (2022) [bib]
    
    @ARTICLE{kivinen2022accfe55734,
      author = {Kivinen, K.~ and van Luenen, H.G.~ and Alcalay, M.~ and Bock, C.~ and Dodzian, J.~ and Hoskova, K.~ and Hoyle, D.~ and Hradil, O.~ and Christensen, S.K.~ and Korn, B.~ and Kosteas, T.~ and Morales, M.~ and Skowronek, K.~ and Theodorou, V.~ and Van Minnebruggen, G.~ and Salamero, J.~ and Premvardhan, L.~},
      title = {Acknowledging and Citing Core Facilities: Key Contributions to Data Lifecycle Should Be Recognised in the Scientific Literature.},
      journal = {EMBO Reports},
      year = {2022},
      volume = {23},
      number = {9},
      pages = {e55734},
      doi = {10.15252/embr.202255734}
    }
  • Vértesy Á., Eichmüller O.L., Naas J., Novatchkova M., Esk C., Balmaña M., Ladstaetter S., Bock C., von Haeseler A., Knoblich J.A.
    Gruffi: An Algorithm for Computational Removal of Stressed Cells from Brain Organoid Transcriptomic Datasets.
    EMBO Journal 41(17):e111118, (2022) [bib]
    
    @ARTICLE{vértesy2022gacre111118,
      author = {Vértesy, Á.~ and Eichm{\"u}ller, O.L.~ and Naas, J.~ and Novatchkova, M.~ and Esk, C.~ and Balmaña, M.~ and Ladstaetter, S.~ and Bock, C.~ and von Haeseler, A.~ and Knoblich, J.A.~},
      title = {Gruffi: An Algorithm for Computational Removal of Stressed Cells from Brain Organoid Transcriptomic Datasets.},
      journal = {EMBO Journal},
      year = {2022},
      volume = {41},
      number = {17},
      pages = {e111118},
      issn = {1460-2075},
      doi = {10.15252/embj.2022111118}
    }
  • Hamminger P., Marchetti L., Preglej T., Platzer R., Zhu C., Kamnev A., Rica R., Stolz V., Sandner L., Alteneder M., Kaba E., Waltenberger D., Huppa J., Trauner M., Bock C., Lyck R., Bauer J., Dupre L., Seiser C., Boucheron N., Engelhardt B., Ellmeier W.
    Histone Deacetylase 1 Controls CD4(+) T Cell Trafficking in Autoinflammatory Diseases.
    European Journal of Immunology 52(Suppl 1: Special Issue: Abstracts Joint Meeting of the German Society for Immunology (DGfl) and the Austrian Society for Allergology & Immunology (ÖGAI), Hannover, Germany, 7–10 September 2022), 298–299, (2022) [bib]
    
    @ARTICLE{hamminger2022hd1c298299,
      author = {Hamminger, P.~ and Marchetti, L.~ and Preglej, T.~ and Platzer, R.~ and Zhu, C.~ and Kamnev, A.~ and Rica, R.~ and Stolz, V.~ and Sandner, L.~ and Alteneder, M.~ and Kaba, E.~ and Waltenberger, D.~ and Huppa, J.~ and Trauner, M.~ and Bock, C.~ and Lyck, R.~ and Bauer, J.~ and Dupre, L.~ and Seiser, C.~ and Boucheron, N.~ and Engelhardt, B.~ and Ellmeier, W.~},
      title = {Histone Deacetylase 1 Controls CD4(+) T Cell Trafficking in Autoinflammatory Diseases.},
      journal = {European Journal of Immunology},
      year = {2022},
      volume = {52},
      number = {Suppl 1: Special Issue: Abstracts Joint Meeting of the German Society for Immunology (DGfl) and the Austrian Society for Allergology \& Immunology ({\"O}GAI), Hannover, Germany, 7–10 September 2022},
      pages = {298--299},
      issn = {0014-2980},
      doi = {https://doi.org/10.1002/eji.202270100},
      url = {https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202270100#page=298}
    }
  • Nenning K., Gesperger J., Nemc A., Roetzer-Pejrimovsky T., Choi S., Preusser M., Nam D., Bock C., Langs G., Woehrer A., ABTR-PCNSL Study Group
    Radiomic Features and DNA Methylation Attributes in Primary CNS Lymphoma.
    Neuro-Oncology 24(Suppl 2: Abstracts 17th Meeting of the European Association of Neuro-Oncology, Vienna, Austria, 15–18 September 2022), ii1, (2022) [bib]
    
    @ARTICLE{nenning2022rfdmii1ii1,
      author = {Nenning, K.~ and Gesperger, J.~ and Nemc, A.~ and Roetzer-Pejrimovsky, T.~ and Choi, S.~ and Preusser, M.~ and Nam, D.~ and Bock, C.~ and Langs, G.~ and Woehrer, A.~ and {ABTR-PCNSL Study Group}},
      title = {Radiomic Features and DNA Methylation Attributes in Primary CNS Lymphoma.},
      journal = {Neuro-Oncology},
      year = {2022},
      volume = {24},
      number = {Suppl 2: Abstracts 17th Meeting of the European Association of Neuro-Oncology, Vienna, Austria, 15–18 September 2022},
      pages = {ii1},
      issn = {1522-8517},
      doi = {10.1093/neuonc/noac174.000}
    }
  • Casteels T., Bajew S., Reiniš J., Enders L., Schuster M., Fontaine F., Müller A.C., Wagner B.K., Bock C., Kubicek S.
    SMNDC1 Links Chromatin Remodeling and Splicing to Regulate Pancreatic Hormone Expression.
    Cell Reports 40(9):111288, (2022) [bib]
    
    @ARTICLE{casteels2022slcr111288,
      author = {Casteels, T.~ and Bajew, S.~ and Reiniš, J.~ and Enders, L.~ and Schuster, M.~ and Fontaine, F.~ and M{\"u}ller, A.C.~ and Wagner, B.K.~ and Bock, C.~ and Kubicek, S.~},
      title = {SMNDC1 Links Chromatin Remodeling and Splicing to Regulate Pancreatic Hormone Expression.},
      journal = {Cell Reports},
      year = {2022},
      volume = {40},
      number = {9},
      pages = {111288},
      issn = {2211-1247},
      doi = {10.1016/j.celrep.2022.111288},
      keywords = {splicing;alpha cells;beta cells;chromatin remodelers;CP: Metabolism;CP: Molecular biology;insulin transcription;pancreatic islets;RNAi screen;SMNDC1}
    }
  • Hess L., Moos V., Lauber A.A., Reiter W., Schuster M., Hartl N., Lackner D., Boenke T., Koren A., Guzzardo P.M., Gundacker B., Riegler A., Vician P., Miccolo C., Leiter S., Chandrasekharan M.B., Vcelkova T., Tanzer A., Jun J.Q., Bradner J., Brosch G., Hartl M., Bock C., Bürckstümmer T., Kubicek S., Chiocca S., Bhaskara S., Seiser C.
    A Toolbox for Class I HDACs Reveals Isoform Specific Roles in Gene Regulation and Protein Acetylation.
    PLoS Genetics 18(8):e1010376, (2022) [bib]
    
    @ARTICLE{hess2022atcie1010376,
      author = {Hess, L.~ and Moos, V.~ and Lauber, A.A.~ and Reiter, W.~ and Schuster, M.~ and Hartl, N.~ and Lackner, D.~ and Boenke, T.~ and Koren, A.~ and Guzzardo, P.M.~ and Gundacker, B.~ and Riegler, A.~ and Vician, P.~ and Miccolo, C.~ and Leiter, S.~ and Chandrasekharan, M.B.~ and Vcelkova, T.~ and Tanzer, A.~ and Jun, J.Q.~ and Bradner, J.~ and Brosch, G.~ and Hartl, M.~ and Bock, C.~ and B{\"u}rckst{\"u}mmer, T.~ and Kubicek, S.~ and Chiocca, S.~ and Bhaskara, S.~ and Seiser, C.~},
      title = {A Toolbox for Class I HDACs Reveals Isoform Specific Roles in Gene Regulation and Protein Acetylation.},
      journal = {PLoS Genetics},
      year = {2022},
      volume = {18},
      number = {8},
      pages = {e1010376},
      issn = {1553-7404 1553-7390},
      doi = {10.1371/journal.pgen.1010376}
    }
  • Deroissart J., Romanovskaia D., Derdak S., Schulte C., Polzl D., Jeitler M., Goderle L., Bock C., Bilban M., Maric H., Binder C.
    Impact of Dyslipidemia on the IgM Repertoire in Atherosclerotic Mice.
    Atherosclerosis 355(Abstracts EAS Congress 2022, Valencia, Spain, 27 June – 1 July 2022), e239, (2022) [bib]
    
    @ARTICLE{deroissart2022idire239e239,
      author = {Deroissart, J.~ and Romanovskaia, D.~ and Derdak, S.~ and Schulte, C.~ and Polzl, D.~ and Jeitler, M.~ and Goderle, L.~ and Bock, C.~ and Bilban, M.~ and Maric, H.~ and Binder, C.~},
      title = {Impact of Dyslipidemia on the IgM Repertoire in Atherosclerotic Mice.},
      journal = {Atherosclerosis},
      year = {2022},
      volume = {355},
      number = {Abstracts EAS Congress 2022, Valencia, Spain, 27 June – 1 July 2022},
      pages = {e239},
      issn = {0021-9150},
      url = {https://www.atherosclerosis-journal.com/article/S0021-9150(22)00967-4/pdf}
    }
  • Varn F.S., Johnson K.C., Martinek J., Huse J.T., Nasrallah M.P., Wesseling P., Cooper L.A.D., Malta T.M., Wade T.E., Sabedot T.S., Brat D., Gould P.V., Wöehrer A., Aldape K., Ismail A., Sivajothi S.K., Barthel F.P., Kim H., Kocakavuk E., Ahmed N., White K., Datta I., Moon H.-E., Pollock S., Goldfarb C., Lee G.-H., Garofano L., Anderson K.J., Nehar-Belaid D., Barnholtz-Sloan J.S., Bakas S., Byrne A.T., D´Angelo F., Gan H.K., Khasraw M., Migliozzi S., Ormond D.R., Paek S.H., Van Meir E.G., Walenkamp A.M.E., Watts C., Weiss T., Weller M., Palucka K., Stead L.F., Poisson L.M., Noushmehr H., Iavarone A., Verhaak R.G.W., GLASS Consortium: Bock C.
    Glioma Progression Is Shaped by Genetic Evolution and Microenvironment Interactions.
    Cell 185(12), 2184–2199.e16, (2022) [bib]
    
    @ARTICLE{varn2022gpis21842199e16,
      author = {Varn, F.S.~ and Johnson, K.C.~ and Martinek, J.~ and Huse, J.T.~ and Nasrallah, M.P.~ and Wesseling, P.~ and Cooper, L.A.D.~ and Malta, T.M.~ and Wade, T.E.~ and Sabedot, T.S.~ and Brat, D.~ and Gould, P.V.~ and W{\"o}ehrer, A.~ and Aldape, K.~ and Ismail, A.~ and Sivajothi, S.K.~ and Barthel, F.P.~ and Kim, H.~ and Kocakavuk, E.~ and Ahmed, N.~ and White, K.~ and Datta, I.~ and Moon, H.-E.~ and Pollock, S.~ and Goldfarb, C.~ and Lee, G.-H.~ and Garofano, L.~ and Anderson, K.J.~ and Nehar-Belaid, D.~ and Barnholtz-Sloan, J.S.~ and Bakas, S.~ and Byrne, A.T.~ and D´Angelo, F.~ and Gan, H.K.~ and Khasraw, M.~ and Migliozzi, S.~ and Ormond, D.R.~ and Paek, S.H.~ and Van Meir, E.G.~ and Walenkamp, A.M.E.~ and Watts, C.~ and Weiss, T.~ and Weller, M.~ and Palucka, K.~ and Stead, L.F.~ and Poisson, L.M.~ and Noushmehr, H.~ and Iavarone, A.~ and Verhaak, R.G.W.~ and {GLASS Consortium}},
      title = {Glioma Progression Is Shaped by Genetic Evolution and Microenvironment Interactions.},
      journal = {Cell},
      year = {2022},
      volume = {185},
      number = {12},
      pages = {2184--2199.e16},
      issn = {1097-4172 0092-8674},
      doi = {10.1016/j.cell.2022.04.038},
      keywords = {genomics;glioblastoma;glioma;hypermutation;macrophages;microenvironment;neurons;single-cell;spatial imaging;treatment resistance}
    }
  • Radu E., Masseron A., Amman F., Schedl A., Agerer B., Endler L., Penz T., Bock C., Bergthaler A., Vierheilig J., Hufnagl P., Korschineck I., Krampe J., Kreuzinger N.
    Emergence of SARS-CoV-2 Alpha Lineage and Its Correlation with Quantitative Wastewater-Based Epidemiology Data.
    Water Research 215:118257, (2022) [bib]
    
    @ARTICLE{radu2022esal118257,
      author = {Radu, E.~ and Masseron, A.~ and Amman, F.~ and Schedl, A.~ and Agerer, B.~ and Endler, L.~ and Penz, T.~ and Bock, C.~ and Bergthaler, A.~ and Vierheilig, J.~ and Hufnagl, P.~ and Korschineck, I.~ and Krampe, J.~ and Kreuzinger, N.~},
      title = {Emergence of SARS-CoV-2 Alpha Lineage and Its Correlation with Quantitative Wastewater-Based Epidemiology Data.},
      journal = {Water Research},
      year = {2022},
      volume = {215},
      pages = {118257},
      issn = {1879-2448},
      doi = {10.1016/j.watres.2022.118257}
    }
  • Milosevic Feenstra J.D., Jäger R., Schischlik F., Ivanov D., Eisenwort G., Rumi E., Schuster M., Gisslinger B., Machherndl-Spandl S., Bettelheim P., Krauth M.-T., Keil F., Bock C., Cazzola M., Gisslinger H., Kralovics R., Valent P.
    PD-L1 Overexpression Correlates with JAK2-V617F Mutational Burden and Is Associated with 9p Uniparental Disomy in Myeloproliferative Neoplasms.
    American Journal of Hematology 97(4), 390–400, (2022) [bib]
    
    @ARTICLE{milosevicfeenstra2022pocw390400,
      author = {Milosevic Feenstra, J.D.~ and J{\"a}ger, R.~ and Schischlik, F.~ and Ivanov, D.~ and Eisenwort, G.~ and Rumi, E.~ and Schuster, M.~ and Gisslinger, B.~ and Machherndl-Spandl, S.~ and Bettelheim, P.~ and Krauth, M.-T.~ and Keil, F.~ and Bock, C.~ and Cazzola, M.~ and Gisslinger, H.~ and Kralovics, R.~ and Valent, P.~},
      title = {PD-L1 Overexpression Correlates with JAK2-V617F Mutational Burden and Is Associated with 9p Uniparental Disomy in Myeloproliferative Neoplasms.},
      journal = {American Journal of Hematology},
      year = {2022},
      volume = {97},
      number = {4},
      pages = {390--400},
      issn = {1096-8652 0361-8609},
      doi = {10.1002/ajh.26461}
    }
  • Stolz V., Rica R., Zhu C., Preglej T., Hamminger P., Hainberger D., Alteneder M., Müller L., Waltenberger D., Hladik A., Agerer B., Schuster M., Frey T., Krausgruber T., Boucheron N., Knapp S., Schmetterer K., Trauner M., Bergthaler A., Bock C., Ellmeier W.
    Nuclear Receptor Corepressor 1 Controls Regulatory T Cell Subset Differentiation and Effector Function.
    bioRxiv 2022.03.24.485609, (2022) [bib]
    
    @ARTICLE{stolz2022nrc120220324485609,
      author = {Stolz, V.~ and Rica, R.~ and Zhu, C.~ and Preglej, T.~ and Hamminger, P.~ and Hainberger, D.~ and Alteneder, M.~ and M{\"u}ller, L.~ and Waltenberger, D.~ and Hladik, A.~ and Agerer, B.~ and Schuster, M.~ and Frey, T.~ and Krausgruber, T.~ and Boucheron, N.~ and Knapp, S.~ and Schmetterer, K.~ and Trauner, M.~ and Bergthaler, A.~ and Bock, C.~ and Ellmeier, W.~},
      title = {Nuclear Receptor Corepressor 1 Controls Regulatory T Cell Subset Differentiation and Effector Function.},
      journal = {bioRxiv},
      year = {2022},
      pages = {2022.03.24.485609},
      url = {https://www.biorxiv.org/content/10.1101/2022.03.24.485609v2}
    }
  • Bangert C., Villazala-Merino S., Fahrenberger M., Krausgruber T., Bauer W.M., Stanek V., Campion N.J., Bartosik T., Quint T., Regelsberger G., Niederberger-Leppin V., Bock C., Schneider S., Eckl-Dorna J.
    Comprehensive Analysis of Nasal Polyps Reveals a More Pronounced Type 2 Transcriptomic Profile of Epithelial Cells and Mast Cells in Aspirin-Exacerbated Respiratory Disease.
    Frontiers in Immunology 13:850494, (2022) [bib]
    
    @ARTICLE{bangert2022canp850494,
      author = {Bangert, C.~ and Villazala-Merino, S.~ and Fahrenberger, M.~ and Krausgruber, T.~ and Bauer, W.M.~ and Stanek, V.~ and Campion, N.J.~ and Bartosik, T.~ and Quint, T.~ and Regelsberger, G.~ and Niederberger-Leppin, V.~ and Bock, C.~ and Schneider, S.~ and Eckl-Dorna, J.~},
      title = {Comprehensive Analysis of Nasal Polyps Reveals a More Pronounced Type 2 Transcriptomic Profile of Epithelial Cells and Mast Cells in Aspirin-Exacerbated Respiratory Disease.},
      journal = {Frontiers in Immunology},
      year = {2022},
      volume = {13},
      pages = {850494},
      issn = {1664-3224},
      doi = {10.3389/fimmu.2022.850494},
      keywords = {Humans;Transcriptome;Chronic Disease;Inflammation/pathology;*Asthma;Aspirin-Induced/genetics/pathology;*Eosinophilia/pathology;*Nasal Polyps/metabolism;*Sinusitis;aspirin-exacerbated respiratory disease;Aspirin/adverse effects;chronic rhinosinusitis with nasal polyps;Epithelial Cells/metabolism;mast cells;Mast Cells/metabolism;scRNA-seq analysis;type 2 immunity}
    }
  • Peneder P., Bock C., Tomazou E.M.
    LIQUORICE: Detection of Epigenetic Signatures in Liquid Biopsies Based on Whole-Genome Sequencing Data.
    Bioinformatics Advances 2:vbac017, (2022) [bib]
    
    @ARTICLE{peneder2022ldesvbac017,
      author = {Peneder, P.~ and Bock, C.~ and Tomazou, E.M.~},
      title = {LIQUORICE: Detection of Epigenetic Signatures in Liquid Biopsies Based on Whole-Genome Sequencing Data.},
      journal = {Bioinformatics Advances},
      year = {2022},
      volume = {2},
      pages = {vbac017},
      issn = {2635-0041},
      doi = {10.1093/bioadv/vbac017},
      url = {https://doi.org/10.1093/bioadv/vbac017}
    }
  • Redl A., Krausgruber T., Barreca D., Doberer K., Unterluggauer L., Kleissl L., Atzmuller D., Mayerhofer C., Kopf A., Weichhart T., Bock C., Stary G.
    Single-Cell and Spatial Architecture of Human Tissue Granulomas Reveals an Aberrant Immune-Regulatory Program Underlying Sarcoidosis.
    Experimental Dermatology 31(2, Abstracts 48th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF), Virtual, 23–26 February 2022), e69–e70, (2022) [bib]
    
    @ARTICLE{redl2022ssahe69e70,
      author = {Redl, A.~ and Krausgruber, T.~ and Barreca, D.~ and Doberer, K.~ and Unterluggauer, L.~ and Kleissl, L.~ and Atzmuller, D.~ and Mayerhofer, C.~ and Kopf, A.~ and Weichhart, T.~ and Bock, C.~ and Stary, G.~},
      title = {Single-Cell and Spatial Architecture of Human Tissue Granulomas Reveals an Aberrant Immune-Regulatory Program Underlying Sarcoidosis.},
      journal = {Experimental Dermatology},
      year = {2022},
      volume = {31},
      number = {2, Abstracts 48th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF), Virtual, 23–26 February 2022},
      pages = {e69--e70},
      issn = {0906-6705},
      doi = {10.1111/exd.14511}
    }
  • Alkon N., Bauer W., Krausgruber T., Goh I., Griss J., Nguyen V., Reininger B., Bangert C., Staud C., Brunner P.M., Bock C., Haniffa M., Stingl G.
    Single-Cell Analysis Reveals Innate Lymphoid Cell Lineage Infidelity in Atopic Dermatitis.
    Journal of Allergy and Clinical Immunology 149(2), 624–639, (2022) [bib]
    
    @ARTICLE{alkon2022sari624639,
      author = {Alkon, N.~ and Bauer, W.~ and Krausgruber, T.~ and Goh, I.~ and Griss, J.~ and Nguyen, V.~ and Reininger, B.~ and Bangert, C.~ and Staud, C.~ and Brunner, P.M.~ and Bock, C.~ and Haniffa, M.~ and Stingl, G.~},
      title = {Single-Cell Analysis Reveals Innate Lymphoid Cell Lineage Infidelity in Atopic Dermatitis.},
      journal = {Journal of Allergy and Clinical Immunology},
      year = {2022},
      volume = {149},
      number = {2},
      pages = {624--639},
      issn = {1097-6825 0091-6749},
      doi = {10.1016/j.jaci.2021.07.025},
      keywords = {atopic dermatitis;human skin;Innate lymphoid cells;single-cell RNA-sequencing}
    }
  • Haimel M., Pazmandi J., Heredia R.J., Dmytrus J., Bal S.K., Zoghi S., van Daele P., Briggs T.A., Wouters C., Bader-Meunier B., Aeschlimann F.A., Caorsi R., Eleftheriou D., Hoppenreijs E., Salzer E., Bakhtiar S., Derfalvi B., Saettini F., Kusters M.A.A., Elfeky R., Trück J., Rivière J.G., van der Burg M., Gattorno M., Seidel M.G., Burns S., Warnatz K., Hauck F., Brogan P., Gilmour K.C., Schuetz C., Simon A., Bock C., Hambleton S., de Vries E., Robinson P., van Gijn M., Boztug K.
    Curation and Expansion of Human Phenotype Ontology for Defined Groups of Inborn Errors of Immunity.
    Journal of Allergy and Clinical Immunology 149(1), 369–378, (2022) [bib]
    
    @ARTICLE{haimel2022cehp369378,
      author = {Haimel, M.~ and Pazmandi, J.~ and Heredia, R.J.~ and Dmytrus, J.~ and Bal, S.K.~ and Zoghi, S.~ and van Daele, P.~ and Briggs, T.A.~ and Wouters, C.~ and Bader-Meunier, B.~ and Aeschlimann, F.A.~ and Caorsi, R.~ and Eleftheriou, D.~ and Hoppenreijs, E.~ and Salzer, E.~ and Bakhtiar, S.~ and Derfalvi, B.~ and Saettini, F.~ and Kusters, M.A.A.~ and Elfeky, R.~ and Tr{\"u}ck, J.~ and Rivière, J.G.~ and van der Burg, M.~ and Gattorno, M.~ and Seidel, M.G.~ and Burns, S.~ and Warnatz, K.~ and Hauck, F.~ and Brogan, P.~ and Gilmour, K.C.~ and Schuetz, C.~ and Simon, A.~ and Bock, C.~ and Hambleton, S.~ and de Vries, E.~ and Robinson, P.~ and van Gijn, M.~ and Boztug, K.~},
      title = {Curation and Expansion of Human Phenotype Ontology for Defined Groups of Inborn Errors of Immunity.},
      journal = {Journal of Allergy and Clinical Immunology},
      year = {2022},
      volume = {149},
      number = {1},
      pages = {369--378},
      issn = {1097-6825 0091-6749},
      doi = {10.1016/j.jaci.2021.04.033},
      keywords = {rare diseases;diagnostic support;disease classification;genetic analysis;HPO;immune deficiencies;inborn errors of immunity;ontology;patient matching;phenotype}
    }

2021

  • Lehmann D., Unterthurner S., Berg V., Hock K., Ponnuswamy P., Malisauskas M., Crowe B.A., Erguener B., Bock C., Hather G., Reipert B.M., Bilic I.
    Comprehensive Approach for Identification of Functional FCGR2C Alleles Resulting in Protein Expression as a Determinant for Predicting Predisposition to Autoimmunity.
    ImmunoMedicine 1(2):e1027, (2021) [bib]
    
    @ARTICLE{lehmann2021caife1027,
      author = {Lehmann, D.~ and Unterthurner, S.~ and Berg, V.~ and Hock, K.~ and Ponnuswamy, P.~ and Malisauskas, M.~ and Crowe, B.A.~ and Erguener, B.~ and Bock, C.~ and Hather, G.~ and Reipert, B.M.~ and Bilic, I.~},
      title = {Comprehensive Approach for Identification of Functional FCGR2C Alleles Resulting in Protein Expression as a Determinant for Predicting Predisposition to Autoimmunity.},
      journal = {ImmunoMedicine},
      year = {2021},
      volume = {1},
      number = {2},
      pages = {e1027},
      issn = {2510-5345},
      doi = {10.1002/imed.1027},
      url = {https://doi.org/10.1002/imed.1027},
      keywords = {SNP;copy number variation;FCGR2C expression;low affinity immunoglobulin receptors;systemic lupus erythematosus}
    }
  • Casteels T., Zhang Y., Frogne T., Sturtzel C., Lardeau C.-H., Sen I., Liu X., Hong S., Pauler F.M., Penz T., Brandstetter M., Barbieux C., Berishvili E., Heuser T., Bock C., Riedel C.G., Meyer D., Distel M., Hecksher-Sørensen J., Li J., Kubicek S.
    An Inhibitor-Mediated Beta Cell Dedifferentiation Model Reveals Distinct Roles for FoxO1 in Glucagon Repression and Insulin Maturation.
    Molecular Metabolism 54:101329, (2021) [bib]
    
    @ARTICLE{casteels2021ibcd101329,
      author = {Casteels, T.~ and Zhang, Y.~ and Frogne, T.~ and Sturtzel, C.~ and Lardeau, C.-H.~ and Sen, I.~ and Liu, X.~ and Hong, S.~ and Pauler, F.M.~ and Penz, T.~ and Brandstetter, M.~ and Barbieux, C.~ and Berishvili, E.~ and Heuser, T.~ and Bock, C.~ and Riedel, C.G.~ and Meyer, D.~ and Distel, M.~ and Hecksher-Sørensen, J.~ and Li, J.~ and Kubicek, S.~},
      title = {An Inhibitor-Mediated Beta Cell Dedifferentiation Model Reveals Distinct Roles for FoxO1 in Glucagon Repression and Insulin Maturation.},
      journal = {Molecular Metabolism},
      year = {2021},
      volume = {54},
      pages = {101329},
      issn = {2212-8778},
      doi = {10.1016/j.molmet.2021.101329},
      keywords = {Diabetes/Beta Cell Dedifferentiation/FoxO1 inhibitor/Loperamide}
    }
  • Alkon N., Bauer W., Krausgruber T., Goh I., Griss J., Nguyen V., Reininger B., Bangert C., Staud C., Brunner P., Bock C., Haniffa M., Stingl G.
    Single-Cell Analysis Unravels Lineage Plasticity of Innate Lymphoid Cells in Atopic Dermatitis.
    Experimental Dermatology 30(Suppl 2: Abstracts 4th Inflammatory Skin Disease Summit, New York, NY, 3–6 November 2021), 34–35, (2021) [bib]
    
    @ARTICLE{alkon2021saul3435,
      author = {Alkon, N.~ and Bauer, W.~ and Krausgruber, T.~ and Goh, I.~ and Griss, J.~ and Nguyen, V.~ and Reininger, B.~ and Bangert, C.~ and Staud, C.~ and Brunner, P.~ and Bock, C.~ and Haniffa, M.~ and Stingl, G.~},
      title = {Single-Cell Analysis Unravels Lineage Plasticity of Innate Lymphoid Cells in Atopic Dermatitis.},
      journal = {Experimental Dermatology},
      year = {2021},
      volume = {30},
      number = {Suppl 2: Abstracts 4th Inflammatory Skin Disease Summit, New York, NY, 3–6 November 2021},
      pages = {34--35},
      issn = {0906-6705},
      url = {https://onlinelibrary.wiley.com/doi/10.1111/exd.14457}
    }
  • Strobl J., Gail L.M., Kleissl L., Pandey R.V., Smejkal V., Huber J., Puxkandl V., Unterluggauer L., Dingelmaier-Hovorka R., Atzmüller D., Krausgruber T., Bock C., Wohlfarth P., Rabitsch W., Stary G.
    Human Resident Memory T Cells Exit the Skin and Mediate Systemic Th2-Driven Inflammation.
    Journal of Experimental Medicine 218(11):e20210417, (2021) [bib]
    
    @ARTICLE{strobl2021hrmte20210417,
      author = {Strobl, J.~ and Gail, L.M.~ and Kleissl, L.~ and Pandey, R.V.~ and Smejkal, V.~ and Huber, J.~ and Puxkandl, V.~ and Unterluggauer, L.~ and Dingelmaier-Hovorka, R.~ and Atzm{\"u}ller, D.~ and Krausgruber, T.~ and Bock, C.~ and Wohlfarth, P.~ and Rabitsch, W.~ and Stary, G.~},
      title = {Human Resident Memory T Cells Exit the Skin and Mediate Systemic Th2-Driven Inflammation.},
      journal = {Journal of Experimental Medicine},
      year = {2021},
      volume = {218},
      number = {11},
      pages = {e20210417},
      issn = {1540-9538 0022-1007},
      doi = {10.1084/jem.20210417}
    }
  • Nicholson M.D., Endler L., Popa A., Genger J.-W., Bock C., Michor F., Bergthaler A.
    Response to Comment on “Genomic Epidemiology of Superspreading Events in Austria Reveals Mutational Dynamics and Transmission Properties of SARS-CoV-2”.
    Science Translational Medicine 13(617):eabj3222, (2021) [bib]
    
    @ARTICLE{nicholson2021rtcgeabj3222,
      author = {Nicholson, M.D.~ and Endler, L.~ and Popa, A.~ and Genger, J.-W.~ and Bock, C.~ and Michor, F.~ and Bergthaler, A.~},
      title = {Response to Comment on “Genomic Epidemiology of Superspreading Events in Austria Reveals Mutational Dynamics and Transmission Properties of SARS-CoV-2”.},
      journal = {Science Translational Medicine},
      year = {2021},
      volume = {13},
      number = {617},
      pages = {eabj3222},
      issn = {1946-6242 1946-6234},
      doi = {10.1126/scitranslmed.abj3222}
    }
  • Strobl J., Gail L., Kleissl L., Pandey R., Krausgruber T., Atzmüller D., Wohlfarth P., Bock C., Rabitsch W., Stary G.
    Skin-Resident Memory T Cells Are Poised for Systemic Th2/Th17-Driven Inflammation and May Re-Seed at Distant Sites during Graft-Versus-Host Disease.
    Journal of Investigative Dermatology 141(10, Suppl: Abstracts 50th Annual European Society for Dermatological Research (ESDR) Meeting 2021, Virtual, 22–25 September 2021), S149, (2021) [bib]
    
    @ARTICLE{strobl2021smtcs149s149,
      author = {Strobl, J.~ and Gail, L.~ and Kleissl, L.~ and Pandey, R.~ and Krausgruber, T.~ and Atzm{\"u}ller, D.~ and Wohlfarth, P.~ and Bock, C.~ and Rabitsch, W.~ and Stary, G.~},
      title = {Skin-Resident Memory T Cells Are Poised for Systemic Th2/Th17-Driven Inflammation and May Re-Seed at Distant Sites during Graft-Versus-Host Disease.},
      journal = {Journal of Investigative Dermatology},
      year = {2021},
      volume = {141},
      number = {10, Suppl: Abstracts 50th Annual European Society for Dermatological Research (ESDR) Meeting 2021, Virtual, 22–25 September 2021},
      pages = {S149},
      issn = {0022-202X},
      url = {https://www.jidonline.org/article/S0022-202X(21)01692-4/pdf}
    }
  • Edgar L., Akbar N., Braithwaite A.T., Krausgruber T., Gallart-Ayala H., Bailey J., Corbin A.L., Khoyratty T.E., Chai J.T., Alkhalil M., Rendeiro A.F., Ziberna K., Arya R., Cahill T.J., Bock C., Laurencikiene J., Crabtree M.J., Lemieux M.E., Riksen N.P., Netea M.G., Wheelock C.E., Channon K.M., Rydén M., Udalova I.A., Carnicer R., Choudhury R.P.
    Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis.
    Circulation 144(12), 961–982, (2021) [bib]
    
    @ARTICLE{edgar2021hiti961982,
      author = {Edgar, L.~ and Akbar, N.~ and Braithwaite, A.T.~ and Krausgruber, T.~ and Gallart-Ayala, H.~ and Bailey, J.~ and Corbin, A.L.~ and Khoyratty, T.E.~ and Chai, J.T.~ and Alkhalil, M.~ and Rendeiro, A.F.~ and Ziberna, K.~ and Arya, R.~ and Cahill, T.J.~ and Bock, C.~ and Laurencikiene, J.~ and Crabtree, M.J.~ and Lemieux, M.E.~ and Riksen, N.P.~ and Netea, M.G.~ and Wheelock, C.E.~ and Channon, K.M.~ and Rydén, M.~ and Udalova, I.A.~ and Carnicer, R.~ and Choudhury, R.P.~},
      title = {Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis.},
      journal = {Circulation},
      year = {2021},
      volume = {144},
      number = {12},
      pages = {961--982},
      issn = {1524-4539 0009-7322},
      doi = {10.1161/CIRCULATIONAHA.120.046464},
      keywords = {memory;hyperglycemia;trained immunity;vascular}
    }
  • Min J.L., Hemani G., Hannon E., Dekkers K.F., Castillo-Fernandez J., Luijk R., Carnero-Montoro E., Lawson D.J., Burrows K., Suderman M., Bretherick A.D., Richardson T.G., Klughammer J., Iotchkova V., Sharp G., Al Khleifat A., Shatunov A., Iacoangeli A., McArdle W.L., Ho K.M., Kumar A., Söderhäll C., Soriano-Tárraga C., Giralt-Steinhauer E., Kazmi N., Mason D., McRae A.F., Corcoran D.L., Sugden K., Kasela S., Cardona A., Day F.R., Cugliari G., Viberti C., Guarrera S., Lerro M., Gupta R., Bollepalli S., Mandaviya P., Zeng Y., Clarke T.-K., Walker R.M., Schmoll V., Czamara D., Ruiz-Arenas C., Rezwan F.I., Marioni R.E., Lin T., Awaloff Y., Germain M., Aïssi D., Zwamborn R., van Eijk K., Dekker A., van Dongen J., Hottenga J.-J., Willemsen G., Xu C.-J., Barturen G., Català-Moll F., Kerick M., Wang C., Melton P., Elliott H.R., Shin J., Bernard M., Yet I., Smart M., Gorrie-Stone T., Shaw C., Al Chalabi A., Ring S.M., Pershagen G., Melén E., Jiménez-Conde J., Roquer J., Lawlor D.A., Wright J., Martin N.G., Montgomery G.W., Moffitt T.E., Poulton R., Esko T., Milani L., Metspalu A., Perry J.R.B., Ong K.K., Wareham N.J., Matullo G., Sacerdote C., Panico S., Caspi A., Arseneault L., Gagnon F., Ollikainen M., Kaprio J., Felix J.F., Rivadeneira F., Tiemeier H., van IJzendoorn M.H., Uitterlinden A.G., Jaddoe V.W.V., Haley C., McIntosh A.M., Evans K.L., Murray A., Räikkönen K., Lahti J., Nohr E.A., Sørensen T.I.A., Hansen T., Morgen C.S., Binder E.B., Lucae S., Gonzalez J.R., Bustamante M., Sunyer J., Holloway J.W., Karmaus W., Zhang H., Deary I.J., Wray N.R., Starr J.M., Beekman M., van Heemst D., Slagboom P.E., Morange P.-E., Trégouët D.-A., Veldink J.H., Davies G.E., de Geus E.J.C., Boomsma D.I., Vonk J.M., Brunekreef B., Koppelman G.H., Alarcón-Riquelme M.E., Huang R.-C., Pennell C.E., van Meurs J., Ikram M.A., Hughes A.D., Tillin T., Chaturvedi N., Pausova Z., Paus T., Spector T.D., Kumari M., Schalkwyk L.C., Visscher P.M., Davey Smith G., Bock C., Gaunt T.R., Bell J.T., Heijmans B.T., Mill J., Relton C.L.
    Genomic and Phenotypic Insights from an Atlas of Genetic Effects on DNA Methylation.
    Nature Genetics 53(9), 1311–1321, (2021) [bib]
    
    @ARTICLE{min2021gpia13111321,
      author = {Min, J.L.~ and Hemani, G.~ and Hannon, E.~ and Dekkers, K.F.~ and Castillo-Fernandez, J.~ and Luijk, R.~ and Carnero-Montoro, E.~ and Lawson, D.J.~ and Burrows, K.~ and Suderman, M.~ and Bretherick, A.D.~ and Richardson, T.G.~ and Klughammer, J.~ and Iotchkova, V.~ and Sharp, G.~ and Al Khleifat, A.~ and Shatunov, A.~ and Iacoangeli, A.~ and McArdle, W.L.~ and Ho, K.M.~ and Kumar, A.~ and S{\"o}derh{\"a}ll, C.~ and Soriano-Tárraga, C.~ and Giralt-Steinhauer, E.~ and Kazmi, N.~ and Mason, D.~ and McRae, A.F.~ and Corcoran, D.L.~ and Sugden, K.~ and Kasela, S.~ and Cardona, A.~ and Day, F.R.~ and Cugliari, G.~ and Viberti, C.~ and Guarrera, S.~ and Lerro, M.~ and Gupta, R.~ and Bollepalli, S.~ and Mandaviya, P.~ and Zeng, Y.~ and Clarke, T.-K.~ and Walker, R.M.~ and Schmoll, V.~ and Czamara, D.~ and Ruiz-Arenas, C.~ and Rezwan, F.I.~ and Marioni, R.E.~ and Lin, T.~ and Awaloff, Y.~ and Germain, M.~ and Aïssi, D.~ and Zwamborn, R.~ and van Eijk, K.~ and Dekker, A.~ and van Dongen, J.~ and Hottenga, J.-J.~ and Willemsen, G.~ and Xu, C.-J.~ and Barturen, G.~ and Català-Moll, F.~ and Kerick, M.~ and Wang, C.~ and Melton, P.~ and Elliott, H.R.~ and Shin, J.~ and Bernard, M.~ and Yet, I.~ and Smart, M.~ and Gorrie-Stone, T.~ and Shaw, C.~ and Al Chalabi, A.~ and Ring, S.M.~ and Pershagen, G.~ and Melén, E.~ and Jiménez-Conde, J.~ and Roquer, J.~ and Lawlor, D.A.~ and Wright, J.~ and Martin, N.G.~ and Montgomery, G.W.~ and Moffitt, T.E.~ and Poulton, R.~ and Esko, T.~ and Milani, L.~ and Metspalu, A.~ and Perry, J.R.B.~ and Ong, K.K.~ and Wareham, N.J.~ and Matullo, G.~ and Sacerdote, C.~ and Panico, S.~ and Caspi, A.~ and Arseneault, L.~ and Gagnon, F.~ and Ollikainen, M.~ and Kaprio, J.~ and Felix, J.F.~ and Rivadeneira, F.~ and Tiemeier, H.~ and van IJzendoorn, M.H.~ and Uitterlinden, A.G.~ and Jaddoe, V.W.V.~ and Haley, C.~ and McIntosh, A.M.~ and Evans, K.L.~ and Murray, A.~ and R{\"a}ikk{\"o}nen, K.~ and Lahti, J.~ and Nohr, E.A.~ and Sørensen, T.I.A.~ and Hansen, T.~ and Morgen, C.S.~ and Binder, E.B.~ and Lucae, S.~ and Gonzalez, J.R.~ and Bustamante, M.~ and Sunyer, J.~ and Holloway, J.W.~ and Karmaus, W.~ and Zhang, H.~ and Deary, I.J.~ and Wray, N.R.~ and Starr, J.M.~ and Beekman, M.~ and van Heemst, D.~ and Slagboom, P.E.~ and Morange, P.-E.~ and Trégouët, D.-A.~ and Veldink, J.H.~ and Davies, G.E.~ and de Geus, E.J.C.~ and Boomsma, D.I.~ and Vonk, J.M.~ and Brunekreef, B.~ and Koppelman, G.H.~ and Alarcón-Riquelme, M.E.~ and Huang, R.-C.~ and Pennell, C.E.~ and van Meurs, J.~ and Ikram, M.A.~ and Hughes, A.D.~ and Tillin, T.~ and Chaturvedi, N.~ and Pausova, Z.~ and Paus, T.~ and Spector, T.D.~ and Kumari, M.~ and Schalkwyk, L.C.~ and Visscher, P.M.~ and Davey Smith, G.~ and Bock, C.~ and Gaunt, T.R.~ and Bell, J.T.~ and Heijmans, B.T.~ and Mill, J.~ and Relton, C.L.~},
      title = {Genomic and Phenotypic Insights from an Atlas of Genetic Effects on DNA Methylation.},
      journal = {Nature Genetics},
      year = {2021},
      volume = {53},
      number = {9},
      pages = {1311--1321},
      issn = {1546-1718 1061-4036},
      doi = {10.1038/s41588-021-00923-x}
    }
  • Leber W., Lammel O., Redlberger-Fritz M., Mustafa-Korninger M.E., Glehr R.C., Camp J., Agerer B., Lercher A., Popa A., Genger J.-W., Penz T., Aberle S., Bock C., Bergthaler A., Stiasny K., Hochstrasser E.-M., Hoellinger C., Siebenhofer A., Griffiths C., Panovska-Griffiths J.
    Rapid, Early and Accurate SARS-CoV-2 Detection Using RT-qPCR in Primary Care: A Prospective Cohort Study (REAP-1).
    BMJ Open 11(8):e045225, (2021) [bib]
    
    @ARTICLE{leber2021rease045225,
      author = {Leber, W.~ and Lammel, O.~ and Redlberger-Fritz, M.~ and Mustafa-Korninger, M.E.~ and Glehr, R.C.~ and Camp, J.~ and Agerer, B.~ and Lercher, A.~ and Popa, A.~ and Genger, J.-W.~ and Penz, T.~ and Aberle, S.~ and Bock, C.~ and Bergthaler, A.~ and Stiasny, K.~ and Hochstrasser, E.-M.~ and Hoellinger, C.~ and Siebenhofer, A.~ and Griffiths, C.~ and Panovska-Griffiths, J.~},
      title = {Rapid, Early and Accurate SARS-CoV-2 Detection Using RT-qPCR in Primary Care: A Prospective Cohort Study (REAP-1).},
      journal = {BMJ Open},
      year = {2021},
      volume = {11},
      number = {8},
      pages = {e045225},
      issn = {2044-6055},
      doi = {10.1136/bmjopen-2020-045225},
      keywords = {Humans;Sensitivity and Specificity;Cohort Studies;Prospective Studies;Austria;Primary Health Care;*COVID-19;*public health;*SARS-CoV-2;*primary care;*virology}
    }
  • Bock C.
    Looking into the Past and Future of Cells: Single-Cell Analysis of Epigenetic Cell States in Immunology and Cancer.
    European Journal of Immunology 51(Suppl 1: Abstracts 6th European Congress of Immunology, Virtual Meeting, 1–4 September 2021), 15, (2021) [bib]
    
    @ARTICLE{bock2021lipf1515,
      author = {Bock, C.~},
      title = {Looking into the Past and Future of Cells: Single-Cell Analysis of Epigenetic Cell States in Immunology and Cancer.},
      journal = {European Journal of Immunology},
      year = {2021},
      volume = {51},
      number = {Suppl 1: Abstracts 6th European Congress of Immunology, Virtual Meeting, 1–4 September 2021},
      pages = {15},
      issn = {0014-2980},
      url = {https://onlinelibrary.wiley.com/toc/15214141/2021/51/S1}
    }
  • Strobl J., Gail L.M., Kleissl L., Pandey R.V., Atzmuller D., Krausgruber T., Smejkal V., Huber J., Bock C., Wohlfarth P., Rabitsch W., Stary G.
    Re-Circulating Tissue-Resident Memory T Cells Are Poised for a Systemic Th2-Driven Host-Versus-Graft Reaction after Human Allogeneic Hematopoietic Stem Cell Transplantation.
    European Journal of Immunology 51(Suppl 1: Abstracts 6th European Congress of Immunology, Virtual Meeting, 1–4 September 2021), 73, (2021) [bib]
    
    @ARTICLE{strobl2021rtmt7373,
      author = {Strobl, J.~ and Gail, L.M.~ and Kleissl, L.~ and Pandey, R.V.~ and Atzmuller, D.~ and Krausgruber, T.~ and Smejkal, V.~ and Huber, J.~ and Bock, C.~ and Wohlfarth, P.~ and Rabitsch, W.~ and Stary, G.~},
      title = {Re-Circulating Tissue-Resident Memory T Cells Are Poised for a Systemic Th2-Driven Host-Versus-Graft Reaction after Human Allogeneic Hematopoietic Stem Cell Transplantation.},
      journal = {European Journal of Immunology},
      year = {2021},
      volume = {51},
      number = {Suppl 1: Abstracts 6th European Congress of Immunology, Virtual Meeting, 1–4 September 2021},
      pages = {73},
      issn = {0014-2980},
      url = {https://onlinelibrary.wiley.com/toc/15214141/2021/51/S1}
    }
  • Hamminger P., Marchetti L., Preglej T., Platzer R., Zhu C., Kamnev A., Rica R., Stolz V., Sandner L., Alteneder M., Kaba E., Waltenberger D., Huppa J., Trauner M., Bock C., Lyck R., Bauer J., Dupré L., Seiser C., Boucheron N., Engelhardt B., Ellmeier W.
    Histone Deacetylase 1 Controls CD4+T Cell Trafficking in Autoinflammatory Disease.
    European Journal of Immunology 51(Suppl 1: Abstracts 6th European Congress of Immunology, Virtual Meeting, 1–4 September 2021), 176, (2021) [bib]
    
    @ARTICLE{hamminger2021hd1c176176,
      author = {Hamminger, P.~ and Marchetti, L.~ and Preglej, T.~ and Platzer, R.~ and Zhu, C.~ and Kamnev, A.~ and Rica, R.~ and Stolz, V.~ and Sandner, L.~ and Alteneder, M.~ and Kaba, E.~ and Waltenberger, D.~ and Huppa, J.~ and Trauner, M.~ and Bock, C.~ and Lyck, R.~ and Bauer, J.~ and Dupré, L.~ and Seiser, C.~ and Boucheron, N.~ and Engelhardt, B.~ and Ellmeier, W.~},
      title = {Histone Deacetylase 1 Controls CD4+T Cell Trafficking in Autoinflammatory Disease.},
      journal = {European Journal of Immunology},
      year = {2021},
      volume = {51},
      number = {Suppl 1: Abstracts 6th European Congress of Immunology, Virtual Meeting, 1–4 September 2021},
      pages = {176},
      issn = {0014-2980},
      url = {https://onlinelibrary.wiley.com/toc/15214141/2021/51/S1}
    }
  • Gülich A.F., Rica R., Tizian C., Viczenczova C., Khamina K., Faux T., Hainberger D., Penz T., Bosselut R., Bock C., Laiho A., Elo L.L., Bergthaler A., Ellmeier W., Sakaguchi S.
    Complex Interplay between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells.
    European Journal of Immunology 51(Suppl 1: Abstracts 6th European Congress of Immunology, Virtual Meeting, 1–4 September 2021), 240, (2021) [bib]
    
    @ARTICLE{guelich2021cibm240240,
      author = {G{\"u}lich, A.F.~ and Rica, R.~ and Tizian, C.~ and Viczenczova, C.~ and Khamina, K.~ and Faux, T.~ and Hainberger, D.~ and Penz, T.~ and Bosselut, R.~ and Bock, C.~ and Laiho, A.~ and Elo, L.L.~ and Bergthaler, A.~ and Ellmeier, W.~ and Sakaguchi, S.~},
      title = {Complex Interplay between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells.},
      journal = {European Journal of Immunology},
      year = {2021},
      volume = {51},
      number = {Suppl 1: Abstracts 6th European Congress of Immunology, Virtual Meeting, 1–4 September 2021},
      pages = {240},
      issn = {0014-2980},
      url = {https://onlinelibrary.wiley.com/toc/15214141/2021/51/S1}
    }
  • Jia R., Kutzner L., Koren A., Runggatscher K., Májek P., Müller A.C., Schuster M., Bock C., Loizou J.I., Kubicek S., Kralovics R.
    High-Throughput Drug Screening Identifies the ATR-CHK1 Pathway as a Therapeutic Vulnerability of CALR Mutated Hematopoietic Cells.
    Blood Cancer Journal 11(7):137, (2021) [bib]
    
    @ARTICLE{jia2021hdsi137,
      author = {Jia, R.~ and Kutzner, L.~ and Koren, A.~ and Runggatscher, K.~ and Májek, P.~ and M{\"u}ller, A.C.~ and Schuster, M.~ and Bock, C.~ and Loizou, J.I.~ and Kubicek, S.~ and Kralovics, R.~},
      title = {High-Throughput Drug Screening Identifies the ATR-CHK1 Pathway as a Therapeutic Vulnerability of CALR Mutated Hematopoietic Cells.},
      journal = {Blood Cancer Journal},
      year = {2021},
      volume = {11},
      number = {7},
      pages = {137},
      issn = {2044-5385},
      doi = {10.1038/s41408-021-00531-2}
    }
  • Özkan E., Strobl M.M., Novatchkova M., Yelagandula R., Albanese T.G., Triska P., Endler Lukas., Penz T., Patocka T., Felsenstein V., Vogt A., Tamir I., Seitz T., Födinger M., Herwig R., Indra A., Schmid D., Bock C., Bergthaler A., Stark A., Allerberger F., Elling U., Cochella L.
    High-Throughput Mutational Surveillance of the SARS-CoV-2 Spike Gene.
    medRxiv 2021.07.22.21259587, (2021) [bib]
    
    @ARTICLE{oezkan2021hmss2021072221259587,
      author = {{\"O}zkan, E.~ and Strobl, M.M.~ and Novatchkova, M.~ and Yelagandula, R.~ and Albanese, T.G.~ and Triska, P.~ and Endler, Lukas.~ and Penz, T.~ and Patocka, T.~ and Felsenstein, V.~ and Vogt, A.~ and Tamir, I.~ and Seitz, T.~ and F{\"o}dinger, M.~ and Herwig, R.~ and Indra, A.~ and Schmid, D.~ and Bock, C.~ and Bergthaler, A.~ and Stark, A.~ and Allerberger, F.~ and Elling, U.~ and Cochella, L.~},
      title = {High-Throughput Mutational Surveillance of the SARS-CoV-2 Spike Gene.},
      journal = {medRxiv},
      year = {2021},
      pages = {2021.07.22.21259587},
      url = {http://medrxiv.org/content/early/2021/07/24/2021.07.22.21259587.abstract}
    }
  • Santini L., Halbritter F., Titz-Teixeira F., Suzuki T., Asami M., Ma X., Ramesmayer J., Lackner A., Warr N., Pauler F., Hippenmeyer S., Laue E., Farlik M., Bock C., Beyer A., Perry A.C.F., Leeb M.
    Genomic Imprinting in Mouse Blastocysts Is Predominantly Associated with H3K27me3.
    Nature Communications 12:3804, (2021) [bib]
    
    @ARTICLE{santini2021gimb3804,
      author = {Santini, L.~ and Halbritter, F.~ and Titz-Teixeira, F.~ and Suzuki, T.~ and Asami, M.~ and Ma, X.~ and Ramesmayer, J.~ and Lackner, A.~ and Warr, N.~ and Pauler, F.~ and Hippenmeyer, S.~ and Laue, E.~ and Farlik, M.~ and Bock, C.~ and Beyer, A.~ and Perry, A.C.F.~ and Leeb, M.~},
      title = {Genomic Imprinting in Mouse Blastocysts Is Predominantly Associated with H3K27me3.},
      journal = {Nature Communications},
      year = {2021},
      volume = {12},
      pages = {3804},
      issn = {2041-1723},
      doi = {10.1038/s41467-021-23510-4}
    }
  • Achyutuni S., Nivarthi H., Majoros A., Hug E., Schueller C., Jia R., Varga C., Schuster M., Senekowitsch M., Tsiantoulas D., Kavirayani A., Binder C.J., Bock C., Zagrijtschuk O., Kralovics R.
    Hematopoietic Expression of a Chimeric Murine-Human CALR Oncoprotein Allows the Assessment of Anti-CALR Antibody Immunotherapies in Vivo.
    American Journal of Hematology 96(6), 698–707, (2021) [bib]
    
    @ARTICLE{achyutuni2021heac698707,
      author = {Achyutuni, S.~ and Nivarthi, H.~ and Majoros, A.~ and Hug, E.~ and Schueller, C.~ and Jia, R.~ and Varga, C.~ and Schuster, M.~ and Senekowitsch, M.~ and Tsiantoulas, D.~ and Kavirayani, A.~ and Binder, C.J.~ and Bock, C.~ and Zagrijtschuk, O.~ and Kralovics, R.~},
      title = {Hematopoietic Expression of a Chimeric Murine-Human CALR Oncoprotein Allows the Assessment of Anti-CALR Antibody Immunotherapies in Vivo.},
      journal = {American Journal of Hematology},
      year = {2021},
      volume = {96},
      number = {6},
      pages = {698--707},
      issn = {1096-8652 0361-8609},
      doi = {10.1002/ajh.26171},
      keywords = {Animals;Mice;Transcriptome;Immunotherapy;Mice;Inbred C57BL;*Disease Models;Animal;Mice;Transgenic;Exons/genetics;Sequence Deletion;*Molecular Targeted Therapy;Antibodies;Monoclonal/immunology/*therapeutic use;Blood Platelets/immunology/metabolism;Calreticulin/*antagonists \& inhibitors/genetics/immunology/physiology;Frameshift Mutation;Gene Knock-In Techniques;Hematopoietic Stem Cells/*metabolism;Radiation Chimera;Recombinant Fusion Proteins/genetics/metabolism;Splenomegaly/etiology;Thrombocythemia;Essential/blood/complications/genetics/*therapy}
    }
  • Datlinger P., Rendeiro A.F., Boenke T., Senekowitsch M., Krausgruber T., Barreca D., Bock C.
    Ultra-High-Throughput Single-Cell RNA Sequencing and Perturbation Screening with Combinatorial Fluidic Indexing.
    Nature Methods 18(6), 635–642, (2021) [bib]
    
    @ARTICLE{datlinger2021usrs635642,
      author = {Datlinger, P.~ and Rendeiro, A.F.~ and Boenke, T.~ and Senekowitsch, M.~ and Krausgruber, T.~ and Barreca, D.~ and Bock, C.~},
      title = {Ultra-High-Throughput Single-Cell RNA Sequencing and Perturbation Screening with Combinatorial Fluidic Indexing.},
      journal = {Nature Methods},
      year = {2021},
      volume = {18},
      number = {6},
      pages = {635--642},
      issn = {1548-7105 1548-7091},
      doi = {10.1038/s41592-021-01153-z}
    }
  • Peneder P., Stütz A.M., Surdez D., Krumbholz M., Semper S., Chicard M., Sheffield N.C., Pierron G., Lapouble E., Tötzl M., Ergüner B., Barreca D., Rendeiro A.F., Agaimy A., Boztug H., Engstler G., Dworzak M., Bernkopf M., Taschner-Mandl S., Ambros I.M., Myklebost O., Marec-Bérard P., Burchill S.A., Brennan B., Strauss S.J., Whelan J., Schleiermacher G., Schaefer C., Dirksen U., Hutter C., Boye K., Ambros P.F., Delattre O., Metzler M., Bock C., Tomazou E.M.
    Multimodal Analysis of Cell-Free DNA Whole-Genome Sequencing for Pediatric Cancers with Low Mutational Burden.
    Nature Communications 12:3230, (2021) [bib]
    
    @ARTICLE{peneder2021macd3230,
      author = {Peneder, P.~ and St{\"u}tz, A.M.~ and Surdez, D.~ and Krumbholz, M.~ and Semper, S.~ and Chicard, M.~ and Sheffield, N.C.~ and Pierron, G.~ and Lapouble, E.~ and T{\"o}tzl, M.~ and Erg{\"u}ner, B.~ and Barreca, D.~ and Rendeiro, A.F.~ and Agaimy, A.~ and Boztug, H.~ and Engstler, G.~ and Dworzak, M.~ and Bernkopf, M.~ and Taschner-Mandl, S.~ and Ambros, I.M.~ and Myklebost, O.~ and Marec-Bérard, P.~ and Burchill, S.A.~ and Brennan, B.~ and Strauss, S.J.~ and Whelan, J.~ and Schleiermacher, G.~ and Schaefer, C.~ and Dirksen, U.~ and Hutter, C.~ and Boye, K.~ and Ambros, P.F.~ and Delattre, O.~ and Metzler, M.~ and Bock, C.~ and Tomazou, E.M.~},
      title = {Multimodal Analysis of Cell-Free DNA Whole-Genome Sequencing for Pediatric Cancers with Low Mutational Burden.},
      journal = {Nature Communications},
      year = {2021},
      volume = {12},
      pages = {3230},
      issn = {2041-1723},
      doi = {10.1038/s41467-021-23445-w},
      keywords = {Adolescent;Adult;Female;Humans;Male;Young Adult;Middle Aged;Case-Control Studies;Mutation;Child;Infant;Child;Preschool;DNA Mutational Analysis;Biomarkers;Tumor/*blood/genetics;Bone Neoplasms/blood/*diagnosis/genetics/pathology;Circulating Tumor DNA/*blood/genetics;Liquid Biopsy/methods;Sarcoma;Ewing/blood/*diagnosis/genetics/pathology;Whole Genome Sequencing}
    }
  • Bangert C., Rindler K., Krausgruber T., Alkon N., Thaler F., Ayub T., Vorstandlechner V., Bauer W., Mildner M., Elbe-Buerger A., Griss J., Bock C., Brunner P.
    Persistence of Mature Dendritic Cells, Th2A and Tc2 Cells Characterize Clinically Resolved Atopic Dermatitis under IL-4R-Alpha Blockade.
    Journal of Investigative Dermatology 141(5, Suppl: Abstracts 2021 Society for Investigative Dermatology (SID) Meeting, Virtual, 3–8 May 2021), S115, (2021) [bib]
    
    @ARTICLE{bangert2021pmdcs115s115,
      author = {Bangert, C.~ and Rindler, K.~ and Krausgruber, T.~ and Alkon, N.~ and Thaler, F.~ and Ayub, T.~ and Vorstandlechner, V.~ and Bauer, W.~ and Mildner, M.~ and Elbe-Buerger, A.~ and Griss, J.~ and Bock, C.~ and Brunner, P.~},
      title = {Persistence of Mature Dendritic Cells, Th2A and Tc2 Cells Characterize Clinically Resolved Atopic Dermatitis under IL-4R-Alpha Blockade.},
      journal = {Journal of Investigative Dermatology},
      year = {2021},
      volume = {141},
      number = {5, Suppl: Abstracts 2021 Society for Investigative Dermatology (SID) Meeting, Virtual, 3–8 May 2021},
      pages = {S115},
      issn = {0022-202X},
      url = {https://www.jidonline.org/article/S0022-202X(21)00914-3/pdf}
    }
  • Hamminger P., Marchetti L., Preglej T., Platzer R., Zhu C., Kamnev A., Rica R., Stolz V., Sandner L., Alteneder M., Kaba E., Waltenberger D., Huppa J.B., Trauner M., Bock C., Lyck R., Bauer J., Dupré L., Seiser C., Boucheron N., Engelhardt B., Ellmeier W.
    Histone Deacetylase 1 Controls CD4(+) T Cell Trafficking in Autoinflammatory Diseases.
    Journal of Autoimmunity 119:102610, (2021) [bib]
    
    @ARTICLE{hamminger2021hd1c102610,
      author = {Hamminger, P.~ and Marchetti, L.~ and Preglej, T.~ and Platzer, R.~ and Zhu, C.~ and Kamnev, A.~ and Rica, R.~ and Stolz, V.~ and Sandner, L.~ and Alteneder, M.~ and Kaba, E.~ and Waltenberger, D.~ and Huppa, J.B.~ and Trauner, M.~ and Bock, C.~ and Lyck, R.~ and Bauer, J.~ and Dupré, L.~ and Seiser, C.~ and Boucheron, N.~ and Engelhardt, B.~ and Ellmeier, W.~},
      title = {Histone Deacetylase 1 Controls CD4(+) T Cell Trafficking in Autoinflammatory Diseases.},
      journal = {Journal of Autoimmunity},
      year = {2021},
      volume = {119},
      pages = {102610},
      issn = {1095-9157 0896-8411},
      doi = {10.1016/j.jaut.2021.102610},
      keywords = {Adoptive CD4(+) T cell transfer colitis;Experimental autoimmune encephalomyelitis;Histone deacetylases;T cell migration}
    }
  • Steindl A., Alpar D., Heller G., Mair M.J., Gatterbauer B., Dieckmann K., Widhalm G., Hainfellner J.A., Schmidinger M., Bock C., Müllauer L., Preusser M., Berghoff A.S.
    Tumor Mutational Burden and Immune Infiltrates in Renal Cell Carcinoma and Matched Brain Metastases.
    ESMO Open 6(2):100057, (2021) [bib]
    
    @ARTICLE{steindl2021tmbi100057,
      author = {Steindl, A.~ and Alpar, D.~ and Heller, G.~ and Mair, M.J.~ and Gatterbauer, B.~ and Dieckmann, K.~ and Widhalm, G.~ and Hainfellner, J.A.~ and Schmidinger, M.~ and Bock, C.~ and M{\"u}llauer, L.~ and Preusser, M.~ and Berghoff, A.S.~},
      title = {Tumor Mutational Burden and Immune Infiltrates in Renal Cell Carcinoma and Matched Brain Metastases.},
      journal = {ESMO Open},
      year = {2021},
      volume = {6},
      number = {2},
      pages = {100057},
      issn = {2059-7029},
      doi = {10.1016/j.esmoop.2021.100057},
      url = {https://www.sciencedirect.com/science/article/pii/S2059702921000119},
      keywords = {brain metastases of renal cell carcinoma;tumor microenvironment in renal cell carcinoma;tumor mutational burden in brain metastases;tumor-infiltrating lymphocytes in brain metastases}
    }
  • Gülich A.F., Rica R., Tizian C., Viczenczova C., Khamina K., Faux T., Hainberger D., Penz T., Bosselut R., Bock C., Laiho A., Elo L.L., Bergthaler A., Ellmeier W., Sakaguchi S.
    Complex Interplay between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells.
    Frontiers in Immunology 12:535039, (2021) [bib]
    
    @ARTICLE{guelich2021cibm535039,
      author = {G{\"u}lich, A.F.~ and Rica, R.~ and Tizian, C.~ and Viczenczova, C.~ and Khamina, K.~ and Faux, T.~ and Hainberger, D.~ and Penz, T.~ and Bosselut, R.~ and Bock, C.~ and Laiho, A.~ and Elo, L.L.~ and Bergthaler, A.~ and Ellmeier, W.~ and Sakaguchi, S.~},
      title = {Complex Interplay between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells.},
      journal = {Frontiers in Immunology},
      year = {2021},
      volume = {12},
      pages = {535039},
      issn = {1664-3224},
      doi = {10.3389/fimmu.2021.535039},
      keywords = {cytotoxic T lymphocyte;LCMV;MAZR/PATZ1;memory T cell;Runx3;transcriptional control}
    }
  • Thomas H.F., Kotova E., Jayaram S., Pilz A., Romeike M., Lackner A., Penz T., Bock C., Leeb M., Halbritter F., Wysocka J., Buecker C.
    Temporal Dissection of an Enhancer Cluster Reveals Distinct Temporal and Functional Contributions of Individual Elements.
    Molecular Cell 81(5), 969–982.e13, (2021) [bib]
    
    @ARTICLE{thomas2021tdec969982e13,
      author = {Thomas, H.F.~ and Kotova, E.~ and Jayaram, S.~ and Pilz, A.~ and Romeike, M.~ and Lackner, A.~ and Penz, T.~ and Bock, C.~ and Leeb, M.~ and Halbritter, F.~ and Wysocka, J.~ and Buecker, C.~},
      title = {Temporal Dissection of an Enhancer Cluster Reveals Distinct Temporal and Functional Contributions of Individual Elements.},
      journal = {Molecular Cell},
      year = {2021},
      volume = {81},
      number = {5},
      pages = {969--982.e13},
      issn = {1097-4164 1097-2765},
      doi = {10.1016/j.molcel.2020.12.047},
      keywords = {Animals;Mice;Cell Line;Transcription;Genetic;Signal Transduction;Sequence Analysis;RNA;Exons;Introns;*differentiation;*enhancer;*Enhancer Elements;Genetic;*Gene Expression Regulation;Developmental;*pluripotency;*Promoter Regions;Genetic;*RNA Pol II;*super-enhancer;*transcription;Cell Nucleus/genetics/metabolism;Drosophila melanogaster/genetics/metabolism;Fibroblast Growth Factor 5/*genetics/metabolism;Gene Knockout Techniques;Genes;Reporter;Green Fluorescent Proteins/genetics/metabolism;Histones/genetics/metabolism;Luminescent Proteins/genetics/metabolism;Mouse Embryonic Stem Cells/cytology/*metabolism;RNA Polymerase II/*genetics/metabolism;Single-Cell Analysis}
    }
  • Agerer B., Koblischke M., Gudipati V., Montaño-Gutierrez L.F., Smyth M., Popa A., Genger J.-W., Endler L., Florian D.M., Mühlgrabner V., Graninger M., Aberle S.W., Husa A.-M., Shaw L.E., Lercher A., Gattinger P., Torralba-Gombau R., Trapin D., Penz T., Barreca D., Fae I., Wenda S., Traugott M., Walder G., Pickl W.F., Thiel V., Allerberger F., Stockinger H., Puchhammer-Stöckl E., Weninger W., Fischer G., Hoepler W., Pawelka E., Zoufaly A., Valenta R., Bock C., Paster W., Geyeregger R., Farlik M., Halbritter F., Huppa J.B., Aberle J.H., Bergthaler A.
    SARS-CoV-2 Mutations in MHC-I-Restricted Epitopes Evade CD8(+) T Cell Responses.
    Science Immunology 6(57):eabg6461, (2021) [bib]
    
    @ARTICLE{agerer2021smmeeabg6461,
      author = {Agerer, B.~ and Koblischke, M.~ and Gudipati, V.~ and Montaño-Gutierrez, L.F.~ and Smyth, M.~ and Popa, A.~ and Genger, J.-W.~ and Endler, L.~ and Florian, D.M.~ and M{\"u}hlgrabner, V.~ and Graninger, M.~ and Aberle, S.W.~ and Husa, A.-M.~ and Shaw, L.E.~ and Lercher, A.~ and Gattinger, P.~ and Torralba-Gombau, R.~ and Trapin, D.~ and Penz, T.~ and Barreca, D.~ and Fae, I.~ and Wenda, S.~ and Traugott, M.~ and Walder, G.~ and Pickl, W.F.~ and Thiel, V.~ and Allerberger, F.~ and Stockinger, H.~ and Puchhammer-St{\"o}ckl, E.~ and Weninger, W.~ and Fischer, G.~ and Hoepler, W.~ and Pawelka, E.~ and Zoufaly, A.~ and Valenta, R.~ and Bock, C.~ and Paster, W.~ and Geyeregger, R.~ and Farlik, M.~ and Halbritter, F.~ and Huppa, J.B.~ and Aberle, J.H.~ and Bergthaler, A.~},
      title = {SARS-CoV-2 Mutations in MHC-I-Restricted Epitopes Evade CD8(+) T Cell Responses.},
      journal = {Science Immunology},
      year = {2021},
      volume = {6},
      number = {57},
      pages = {eabg6461},
      issn = {2470-9468},
      doi = {10.1126/sciimmunol.abg6461},
      keywords = {Humans;Cell Proliferation;High-Throughput Nucleotide Sequencing;*Mutation;CD8-Positive T-Lymphocytes/*immunology/pathology;*COVID-19/genetics/immunology/pathology;*Epitopes;T-Lymphocyte/genetics/immunology;*Immunity;Cellular;*SARS-CoV-2/genetics/immunology;HLA-A Antigens/*immunology;Interferon-gamma/immunology;Peptides/genetics/immunology}
    }
  • Schick S., Grosche S., Kohl K.E., Drpic D., Jaeger M.G., Marella N.C., Imrichova H., Lin J.-M.G., Hofstätter G., Schuster M., Rendeiro A.F., Koren A., Petronczki M., Bock C., Müller A.C., Winter G.E., Kubicek S.
    Acute BAF Perturbation Causes Immediate Changes in Chromatin Accessibility.
    Nature Genetics 53(3), 269–278, (2021) [bib]
    
    @ARTICLE{schick2021abpc269278,
      author = {Schick, S.~ and Grosche, S.~ and Kohl, K.E.~ and Drpic, D.~ and Jaeger, M.G.~ and Marella, N.C.~ and Imrichova, H.~ and Lin, J.-M.G.~ and Hofst{\"a}tter, G.~ and Schuster, M.~ and Rendeiro, A.F.~ and Koren, A.~ and Petronczki, M.~ and Bock, C.~ and M{\"u}ller, A.C.~ and Winter, G.E.~ and Kubicek, S.~},
      title = {Acute BAF Perturbation Causes Immediate Changes in Chromatin Accessibility.},
      journal = {Nature Genetics},
      year = {2021},
      volume = {53},
      number = {3},
      pages = {269--278},
      issn = {1546-1718 1061-4036},
      doi = {10.1038/s41588-021-00777-3}
    }
  • Rindler K., Krausgruber T., Thaler F.M., Alkon N., Bangert C., Kurz H., Fortelny N., Rojahn T.B., Jonak C., Griss J., Bock C., Brunner P.M.
    Spontaneously Resolved Atopic Dermatitis Shows Melanocyte and Immune Cell Activation Distinct from Healthy Control Skin.
    Frontiers in Immunology 12:630892, (2021) [bib]
    
    @ARTICLE{rindler2021srad630892,
      author = {Rindler, K.~ and Krausgruber, T.~ and Thaler, F.M.~ and Alkon, N.~ and Bangert, C.~ and Kurz, H.~ and Fortelny, N.~ and Rojahn, T.B.~ and Jonak, C.~ and Griss, J.~ and Bock, C.~ and Brunner, P.M.~},
      title = {Spontaneously Resolved Atopic Dermatitis Shows Melanocyte and Immune Cell Activation Distinct from Healthy Control Skin.},
      journal = {Frontiers in Immunology},
      year = {2021},
      volume = {12},
      pages = {630892},
      issn = {1664-3224},
      doi = {10.3389/fimmu.2021.630892},
      keywords = {atopic dermatitis;eczema;multiplex proteomics;single-cell RNA seq;spontaneous remission}
    }
  • Valent P., Orfao A., Kubicek S., Staber P., Haferlach T., Deininger M., Kollmann K., Lion T., Virgolini I., Winter G., Hantschel O., Kenner L., Zuber J., Grebien F., Moriggl R., Hoermann G., Hermine O., Andreeff M., Bock C., Mughal T., Constantinescu S.N., Kralovics R., Sexl V., Skoda R., Superti-Furga G., Jäger U.
    Precision Medicine in Hematology 2021: Definitions, Tools, Perspectives, and Open Questions.
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      volume = {218},
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      pages = {e20201189},
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      doi = {10.1084/jem.20201189},
      keywords = {Adult;Humans;Middle Aged;Healthy Volunteers;Transcriptome;T-Lymphocytes/*immunology;Cells;Cultured;Cytokines/metabolism;*Immunologic Surveillance;Fetus/*immunology;Intestines/embryology/immunology;Receptors;Antigen;T-Cell;alpha-beta/*genetics;Receptors;Antigen;T-Cell;gamma-delta/*genetics;RNA-Seq/methods;Single-Cell Analysis/methods;Skin/*embryology/growth \& development/*immunology}
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      number = {7842},
      pages = {442--447},
      issn = {1476-4687 0028-0836},
      doi = {10.1038/s41586-020-03071-0},
      keywords = {Animals;Female;Humans;Male;Mice;Pregnancy;Cell Proliferation;Mice;Inbred C57BL;Mice;Inbred BALB C;Glucose/metabolism;Adipocytes/pathology;Diabetes;Gestational/etiology/*immunology/metabolism/pathology;Epithelial Cells/immunology;Fetal Death/*etiology;Fetus/immunology/metabolism/pathology;Glucose Intolerance/genetics;Intra-Abdominal Fat/pathology;Placenta/immunology/pathology;Receptor Activator of Nuclear Factor-kappa B/deficiency/genetics/*metabolism;T-Lymphocytes;Regulatory/cytology/*immunology;Thymus Gland/cytology/*immunology;Transcription Factors/metabolism}
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      title = {Targeting Clinical Epigenetic Reprogramming for Chemoprevention of Metabolic and Viral Hepatocellular Carcinoma.},
      journal = {Gut},
      year = {2021},
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      number = {1},
      pages = {157--169},
      issn = {1468-3288 0017-5749},
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      keywords = {Animals;Humans;Male;Mice;Disease Models;Animal;Mice;Inbred C57BL;*Epigenesis;Genetic;*chemoprevention;*gene expression;*hepatitis C;*hepatocellular carcinoma;*non-alcoholic steatohepatitis;Carcinoma;Hepatocellular/etiology/*prevention \& control;Hepatitis C;Chronic/*complications/genetics/pathology;Liver Neoplasms/etiology/*prevention \& control;Non-alcoholic Fatty Liver Disease/*complications/genetics/pathology}
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