Publikationen von Michael Kenn
2023
- Schreiner W., Karch R., Cibena M., Tomasiak L., Kenn M., Pfeiler G.
Clustering Molecular Dynamics Conformations of the CC’-Loop of the PD-1 Immuno-Checkpoint Receptor.
Computational and Structural Biotechnology Journal 21, 3920–3932, (2023) [bib]
@ARTICLE{schreiner2023cmdc39203932, author = {Schreiner, W.~ and Karch, R.~ and Cibena, M.~ and Tomasiak, L.~ and Kenn, M.~ and Pfeiler, G.~}, title = {Clustering Molecular Dynamics Conformations of the CC’-Loop of the PD-1 Immuno-Checkpoint Receptor.}, journal = {Computational and Structural Biotechnology Journal}, year = {2023}, volume = {21}, pages = {3920--3932}, doi = {10.1016/j.csbj.2023.07.004} }
- Kenn M., Karch R., Singer C.F., Dorffner G., Schreiner W.
Flexible Risk Evidence Combination Rules in Breast Cancer Precision Therapy.
Journal of Personalized Medicine 13(1):119, (2023) [bib]
@ARTICLE{kenn2023frec119, author = {Kenn, M.~ and Karch, R.~ and Singer, C.F.~ and Dorffner, G.~ and Schreiner, W.~}, title = {Flexible Risk Evidence Combination Rules in Breast Cancer Precision Therapy.}, journal = {Journal of Personalized Medicine}, year = {2023}, volume = {13}, number = {1}, pages = {119}, issn = {2075-4426}, doi = {10.3390/jpm13010119}, keywords = {precision medicine;personalized medicine;data science;breast cancer;mathematical oncology;Dempster-Shafer theory;evidence theory;hormone receptor status;theory of belief functions} }
2022
- Schreiner W., Karch R., Cibena M., Tomasiak L., Kenn M., Pfeiler G.
The Performance of UMAP Plus Linkage Compared with Daura-Clustering of Molecular Dynamics of the PD-1 Checkpoint Receptor.
In Adjeroh D., Long Q., Shi X., Guo F., Hu X., Aluru S., Narasimhan G., Wang J., Kang M., Mondal A.M., Liu J. (Eds.) Proceedings 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Las Vegas, USA & Changsha, China, 6–8 December 2022, Institute of Electrical and Electronics Engineers (IEEE), Piscataway, NJ, 3569–3573, (2022) [bib]
@INCOLLECTION{schreiner2022pupl35693573, author = {Schreiner, W.~ and Karch, R.~ and Cibena, M.~ and Tomasiak, L.~ and Kenn, M.~ and Pfeiler, G.~}, title = {The Performance of UMAP Plus Linkage Compared with Daura-Clustering of Molecular Dynamics of the PD-1 Checkpoint Receptor.}, booktitle = {Proceedings 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Las Vegas, USA \& Changsha, China, 6–8 December 2022}, publisher = {Institute of Electrical and Electronics Engineers (IEEE)}, year = {2022}, editor = {Adjeroh,D.;Long,Q.;Shi,X.;Guo,F.;Hu,X.;Aluru,S.;Narasimhan,G.;Wang,J.;Kang,M.;Mondal,A.M.;Liu,J.}, pages = {3569--3573}, address = {Piscataway, NJ}, month = {dec}, url = {https://www.doi.org/10.1109/BIBM55620.2022.9995272} }
- Kenn M., Karch R., Tomasiak L., Cibena M., Pfeiler G., Koelbl H., Schreiner W.
Molecular Dynamics Identifies Semi-Rigid Domains in the PD-1 Checkpoint Receptor Bound to Its Natural Ligand PD-L1.
Frontiers in Bioengineering and Biotechnology 10:838129, (2022) [bib]
@ARTICLE{kenn2022mdis838129, author = {Kenn, M.~ and Karch, R.~ and Tomasiak, L.~ and Cibena, M.~ and Pfeiler, G.~ and Koelbl, H.~ and Schreiner, W.~}, title = {Molecular Dynamics Identifies Semi-Rigid Domains in the PD-1 Checkpoint Receptor Bound to Its Natural Ligand PD-L1.}, journal = {Frontiers in Bioengineering and Biotechnology}, year = {2022}, volume = {10}, pages = {838129}, issn = {2296-4185}, doi = {10.3389/fbioe.2022.838129}, keywords = {molecular dynamics;oncology;checkpoint inhibitor;cluster analysis;drug design;immune therapy} }
- Kenn M., Karch R., Cacsire Castillo-Tong D., Singer C.F., Koelbl H., Schreiner W.
Decision Theory versus Conventional Statistics for Personalized Therapy of Breast Cancer.
Journal of Personalized Medicine 12(4):570, (2022) [bib]
@ARTICLE{kenn2022dtvc570, author = {Kenn, M.~ and Karch, R.~ and Cacsire Castillo-Tong, D.~ and Singer, C.F.~ and Koelbl, H.~ and Schreiner, W.~}, title = {Decision Theory versus Conventional Statistics for Personalized Therapy of Breast Cancer.}, journal = {Journal of Personalized Medicine}, year = {2022}, volume = {12}, number = {4}, pages = {570}, issn = {2075-4426}, doi = {10.3390/jpm12040570}, keywords = {precision medicine;biomarkers;personalized medicine;data science;breast cancer;gene expression;mathematical oncology;receptor status;decision theory} }
- Pichler K.M., Fischer A., Alphonsus J., Chiari C., Schmidt S., Kenn M., Schreiner W., Weinmann D., Rothbauer M., Windhager R., Gabius H.-J., Toegel S.
Galectin Network in Osteoarthritis: Galectin-4 Programs a Pathogenic Signature of Gene and Effector Expression in Human Chondrocytes in Vitro.
Histochemistry and Cell Biology 157(2), 139–151, (2022) [bib]
@ARTICLE{pichler2022gnog139151, author = {Pichler, K.M.~ and Fischer, A.~ and Alphonsus, J.~ and Chiari, C.~ and Schmidt, S.~ and Kenn, M.~ and Schreiner, W.~ and Weinmann, D.~ and Rothbauer, M.~ and Windhager, R.~ and Gabius, H.-J.~ and Toegel, S.~}, title = {Galectin Network in Osteoarthritis: Galectin-4 Programs a Pathogenic Signature of Gene and Effector Expression in Human Chondrocytes in Vitro.}, journal = {Histochemistry and Cell Biology}, year = {2022}, volume = {157}, number = {2}, pages = {139--151}, issn = {1432-119X 0948-6143}, doi = {10.1007/s00418-021-02053-1}, keywords = {Inflammation;Lectin;NF-κB;3D spheres;Cartilage;Primary cells} }
2021
- Kenn M., Cacsire Castillo-Tong D., Singer C.F., Karch R., Cibena M., Koelbl H., Schreiner W.
Decision Theory for Precision Therapy of Breast Cancer.
Scientific Reports 11:4233, (2021) [bib]
@ARTICLE{kenn2021dtpt4233, author = {Kenn, M.~ and Cacsire Castillo-Tong, D.~ and Singer, C.F.~ and Karch, R.~ and Cibena, M.~ and Koelbl, H.~ and Schreiner, W.~}, title = {Decision Theory for Precision Therapy of Breast Cancer.}, journal = {Scientific Reports}, year = {2021}, volume = {11}, pages = {4233}, issn = {2045-2322}, doi = {10.1038/s41598-021-82418-7} }
2020
- Kenn M., Cacsire Castillo-Tong D., Singer C.F., Cibena M., Kölbl H., Schreiner W.
Microarray Normalization Revisited for Reproducible Breast Cancer Biomarkers.
BioMed Research International 2020:1363827, (2020) [bib]
@ARTICLE{kenn2020mnrr1363827, author = {Kenn, M.~ and Cacsire Castillo-Tong, D.~ and Singer, C.F.~ and Cibena, M.~ and K{\"o}lbl, H.~ and Schreiner, W.~}, title = {Microarray Normalization Revisited for Reproducible Breast Cancer Biomarkers.}, journal = {BioMed Research International}, year = {2020}, volume = {2020}, pages = {1363827}, issn = {2314-6141 2314-6133}, doi = {10.1155/2020/1363827} }
- Toegel S., Pichler K.M., Weinmann D., Fiebrich J., Kenn M., Schreiner W., Lass R., Windhager R., Gabius H.-J.
Galectin-4 Triggers Disease Markers in Osteoarthritic Chondrocytes via NF-κB.
Osteoarthritis and Cartilage 28(Suppl 1: Abstracts 2020 OARSI World Congress on Osteoarthritis Promoting Clinical and Basic Research in Osteoarthritis, Vienna, Austria, 30 April–3 May 2020), S94, (2020) [bib]
@ARTICLE{toegel2020gtdms94s94, author = {Toegel, S.~ and Pichler, K.M.~ and Weinmann, D.~ and Fiebrich, J.~ and Kenn, M.~ and Schreiner, W.~ and Lass, R.~ and Windhager, R.~ and Gabius, H.-J.~}, title = {Galectin-4 Triggers Disease Markers in Osteoarthritic Chondrocytes via NF-κB.}, journal = {Osteoarthritis and Cartilage}, year = {2020}, volume = {28}, number = {Suppl 1: Abstracts 2020 OARSI World Congress on Osteoarthritis Promoting Clinical and Basic Research in Osteoarthritis, Vienna, Austria, 30 April–3 May 2020}, pages = {S94}, issn = {1063-4584}, doi = {10.1016/j.joca.2020.02.144}, url = {https://www.sciencedirect.com/science/article/pii/S1063458420302119} }
2019
- Gruber E.S., Oberhuber G., Birner P., Schlederer M., Kenn M., Schreiner W., Jomrich G., Schoppmann S.F., Gnant M., Tse W., Kenner L.
The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer.
Cells 8(11):1357, (2019)
[Erratum: Gruber E.S., Oberhuber G., Birner P., Schlederer M., Kenn M., Schreiner W., Jomrich G., Schoppmann S.F., Gnant M., Tse W., Kenner L. Erratum: Gruber, E.S.; et al. The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer. Cells 2019, 8, 1357. Cells 9(12):2724, (2020)] [bib]
@ARTICLE{gruber2019oaia1357, author = {Gruber, E.S.~ and Oberhuber, G.~ and Birner, P.~ and Schlederer, M.~ and Kenn, M.~ and Schreiner, W.~ and Jomrich, G.~ and Schoppmann, S.F.~ and Gnant, M.~ and Tse, W.~ and Kenner, L.~}, title = {The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer.}, journal = {Cells}, year = {2019}, volume = {8}, number = {11}, pages = {1357}, note = {
[Erratum: Gruber E.S., Oberhuber G., Birner P., Schlederer M., Kenn M., Schreiner W., Jomrich G., Schoppmann S.F., Gnant M., Tse W., Kenner L. Erratum: Gruber, E.S.; et al. The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer. Cells 2019, 8, 1357. Cells 9(12):2724, (2020)]}, issn = {2073-4409 2073-4409}, doi = {10.3390/cells8111357}, keywords = {*prognosis;*AF1Q;*esophageal cancer;*MLLT11;*STAT;*WNT} } - Kinslechner K., Kenn M., Weinmann D., Walzer S.M., Windhager R., Schreiner W., Gabius H.-J., Toegel S.
Combined Activity of Galectin-1,-3, and-8 Drives Functional Disease Markers in Osteoarthritic Chondrocytes via NF-KB.
Osteoarthritis and Cartilage 27(Suppl 1: Abstracts 2019 OARSI World Congress on Osteoarthritis. Promoting Clinical and Basic Research in Osteoarthritis, Toronto, Canada, 2–5 May 2019), S197–S198, (2019) [bib]
@ARTICLE{kinslechner2019cagas197s198, author = {Kinslechner, K.~ and Kenn, M.~ and Weinmann, D.~ and Walzer, S.M.~ and Windhager, R.~ and Schreiner, W.~ and Gabius, H.-J.~ and Toegel, S.~}, title = {Combined Activity of Galectin-1,-3, and-8 Drives Functional Disease Markers in Osteoarthritic Chondrocytes via NF-KB.}, journal = {Osteoarthritis and Cartilage}, year = {2019}, volume = {27}, number = {Suppl 1: Abstracts 2019 OARSI World Congress on Osteoarthritis. Promoting Clinical and Basic Research in Osteoarthritis, Toronto, Canada, 2–5 May 2019}, pages = {S197--S198}, issn = {1063-4584}, doi = {10.1016/j.joca.2019.02.305} }
2018
- Kenn M., Cacsire Castillo-Tong D., Singer C.F., Cibena M., Kölbl H., Schreiner W.
Co-Expressed Genes Enhance Precision of Receptor Status Identification in Breast Cancer Patients.
Breast Cancer Research and Treatment 172(2), 313–326, (2018) [bib]
@ARTICLE{kenn2018cgep313326, author = {Kenn, M.~ and Cacsire Castillo-Tong, D.~ and Singer, C.F.~ and Cibena, M.~ and K{\"o}lbl, H.~ and Schreiner, W.~}, title = {Co-Expressed Genes Enhance Precision of Receptor Status Identification in Breast Cancer Patients.}, journal = {Breast Cancer Research and Treatment}, year = {2018}, volume = {172}, number = {2}, pages = {313--326}, issn = {1573-7217 0167-6806}, doi = {10.1007/s10549-018-4920-x}, keywords = {Female;Humans;Disease-Free Survival;Breast cancer;Biomarkers;Tumor/genetics;Precision Medicine;Gene Expression Regulation;Neoplastic;Data science;Gene expression;Mathematical oncology;Precision medicine;Receptor status;Breast Neoplasms/classification/*genetics/pathology;Estrogen Receptor alpha/*genetics;Receptor;ErbB-2/*genetics;Receptors;Cell Surface;Receptors;Progesterone/*genetics} }
- Weinmann D., Kenn M., Schmidt S., Schmidt K., Walzer S.M., Kubista B., Windhager R., Schreiner W., Toegel S., Gabius H.-J.
Galectin-8 Induces Functional Disease Markers in Human Osteoarthritis and Cooperates with Galectins-1 and -3.
Cellular and Molecular Life Sciences 75(22), 4187–4205, (2018) [bib]
@ARTICLE{weinmann2018gifd41874205, author = {Weinmann, D.~ and Kenn, M.~ and Schmidt, S.~ and Schmidt, K.~ and Walzer, S.M.~ and Kubista, B.~ and Windhager, R.~ and Schreiner, W.~ and Toegel, S.~ and Gabius, H.-J.~}, title = {Galectin-8 Induces Functional Disease Markers in Human Osteoarthritis and Cooperates with Galectins-1 and -3.}, journal = {Cellular and Molecular Life Sciences}, year = {2018}, volume = {75}, number = {22}, pages = {4187--4205}, issn = {1420-9071 1420-682X}, doi = {10.1007/s00018-018-2856-2}, keywords = {Female;Humans;Male;Aged;Middle Aged;Aged;80 and over;Polymorphism;Single Nucleotide;Inflammation;Biomarkers/metabolism;Disease Progression;RNA;Messenger/metabolism;Cells;Cultured;Interleukin;Chondrocytes/metabolism;Gene Expression;Chondrocytes;Galectin 1/metabolism;Galectin 3/metabolism;Galectins/genetics/*metabolism;Lectin;NF-kappa B/metabolism;NF-kappaB;Osteoarthritis/*genetics/metabolism/pathology} }
- Toegel S., Weinmann D., Kenn M., Schreiner W., Walzer S., Gabius H.-J., Windhager R.
Functional Cooperation of Galectin-8 with Galectin-1 and-3 in Triggering Disease Markers of Human Osteoarthritis.
Osteoarthritis and Cartilage 26(Suppl 1: Abstracts OARSI World Congress on Osteoarthritis: Promoting Clinical and Basic Research in Osteoarthritis, Liverpool, UK, 26–29 April 2018), S21–S22, (2018) [bib]
@ARTICLE{toegel2018fcgws21s22, author = {Toegel, S.~ and Weinmann, D.~ and Kenn, M.~ and Schreiner, W.~ and Walzer, S.~ and Gabius, H.-J.~ and Windhager, R.~}, title = {Functional Cooperation of Galectin-8 with Galectin-1 and-3 in Triggering Disease Markers of Human Osteoarthritis.}, journal = {Osteoarthritis and Cartilage}, year = {2018}, volume = {26}, number = {Suppl 1: Abstracts OARSI World Congress on Osteoarthritis: Promoting Clinical and Basic Research in Osteoarthritis, Liverpool, UK, 26–29 April 2018}, pages = {S21--S22}, issn = {1063-4584}, doi = {10.1016/j.joca.2018.02.059}, url = {https://www.oarsijournal.com/issue/S1063-4584(18)X0004-1} }
2017
- Kenn M., Schlangen K., Cacsire Castillo-Tong D., Singer C.F., Cibena M., Koelbl H., Schreiner W.
Gene Expression Information Improves Reliability of Receptor Status in Breast Cancer Patients.
Oncotarget 8(44), 77341–77359, (2017) [bib]
@ARTICLE{kenn2017geii7734177359, author = {Kenn, M.~ and Schlangen, K.~ and Cacsire Castillo-Tong, D.~ and Singer, C.F.~ and Cibena, M.~ and Koelbl, H.~ and Schreiner, W.~}, title = {Gene Expression Information Improves Reliability of Receptor Status in Breast Cancer Patients.}, journal = {Oncotarget}, year = {2017}, volume = {8}, number = {44}, pages = {77341--77359}, issn = {1949-2553 1949-2553}, doi = {10.18632/oncotarget.20474}, keywords = {data science;breast cancer;gene expression;mathematical oncology;receptor status} }
2016
- Kenn M., Ribarics R., Ilieva N., Cibena M., Karch R., Schreiner W.
Spatiotemporal Multistage Consensus Clustering in Molecular Dynamics Studies of Large Proteins.
Molecular BioSystems 12(5), 1600–1614, (2016) [bib]
@ARTICLE{kenn2016smcc16001614, author = {Kenn, M.~ and Ribarics, R.~ and Ilieva, N.~ and Cibena, M.~ and Karch, R.~ and Schreiner, W.~}, title = {Spatiotemporal Multistage Consensus Clustering in Molecular Dynamics Studies of Large Proteins.}, journal = {Molecular BioSystems}, year = {2016}, volume = {12}, number = {5}, pages = {1600--1614}, issn = {1742-2051 1742-2051}, doi = {10.1039/c5mb00879d}, keywords = {Algorithms;Protein Conformation;*Cluster Analysis;*Molecular Dynamics Simulation;CD8 Antigens/chemistry/metabolism;Major Histocompatibility Complex;Models;Molecular;Multiprotein Complexes/chemistry;Protein Interaction Domains and Motifs;Proteins/*chemistry/metabolism;Receptors;Antigen;T-Cell/chemistry/metabolism} }
2015
- Ribarics R., Kenn M., Karch R., Ilieva N., Schreiner W.
Geometry Dynamics of α-Helices in Different Class I Major Histocompatibility Complexes.
Journal of Immunology Research 2015:173593, (2015) [bib]
@ARTICLE{ribarics2015gdhd173593, author = {Ribarics, R.~ and Kenn, M.~ and Karch, R.~ and Ilieva, N.~ and Schreiner, W.~}, title = {Geometry Dynamics of α-Helices in Different Class I Major Histocompatibility Complexes.}, journal = {Journal of Immunology Research}, year = {2015}, volume = {2015}, pages = {173593}, issn = {2314-7156 2314-8861 2314-7156}, doi = {10.1155/2015/173593}, keywords = {Humans;Mutation;Binding Sites;Protein Binding;*Molecular Dynamics Simulation;Protein Interaction Domains and Motifs;HLA-B27 Antigen/*chemistry/immunology;Immunological Synapses/chemistry/immunology;Least-Squares Analysis;Peptides/*chemistry/immunology;Protein Structure;Secondary;Receptors;Antigen;T-Cell/*chemistry/immunology} }
2014
- Kenn M., Ribarics R., Ilieva N., Schreiner W.
Finding Semirigid Domains in Biomolecules by Clustering Pair-Distance Variations.
BioMed Research International 2014:731325, (2014) [bib]
@ARTICLE{kenn2014fsdb731325, author = {Kenn, M.~ and Ribarics, R.~ and Ilieva, N.~ and Schreiner, W.~}, title = {Finding Semirigid Domains in Biomolecules by Clustering Pair-Distance Variations.}, journal = {BioMed Research International}, year = {2014}, volume = {2014}, pages = {731325}, issn = {2314-6141 2314-6133}, doi = {10.1155/2014/731325}, keywords = {Algorithms;Models;Theoretical;Gene Expression Profiling;Oligonucleotide Array Sequence Analysis;Pattern Recognition;Automated;Signal Transduction;Molecular Dynamics Simulation;*Fuzzy Logic;*Cluster Analysis;*Computational Biology;Gene Expression Regulation/genetics/*immunology} }