Publikationen von Rob Ter Horst
2026
- C. dos Santos J., Groenendijk A.L., Ruijten S.D.E., Knoll R., Vadaq N., Ter Horst R., Fok E.T., Witkowski W., Blaauw M.J.T., van Eekeren L.E., Vos W.A.J.W., Cleophas-Jacobs M., Reichl S., Otten T., Martens J.H.A., van der Meer A., Koninkx H., de Jonge M.I., Beyer M.D., van Lunzen J., Joosten L.A.B., Bock C., Rokx C., Verbon A., Vandekerckhove L., Aschenbrenner A.C., Schultze J.L., Matzaraki V., van der Ven A.J.A.M., Netea M.G.
Persistent Viral Control Status Is Associated with Enhanced Innate Immune Responses in People with HIV-1.
iScience 29(3):114807, (2026) [bib]
@ARTICLE{cdossantos2026pvcs114807, author = {C. dos Santos, J.~ and Groenendijk, A.L.~ and Ruijten, S.D.E.~ and Knoll, R.~ and Vadaq, N.~ and Ter Horst, R.~ and Fok, E.T.~ and Witkowski, W.~ and Blaauw, M.J.T.~ and van Eekeren, L.E.~ and Vos, W.A.J.W.~ and Cleophas-Jacobs, M.~ and Reichl, S.~ and Otten, T.~ and Martens, J.H.A.~ and van der Meer, A.~ and Koninkx, H.~ and de Jonge, M.I.~ and Beyer, M.D.~ and van Lunzen, J.~ and Joosten, L.A.B.~ and Bock, C.~ and Rokx, C.~ and Verbon, A.~ and Vandekerckhove, L.~ and Aschenbrenner, A.C.~ and Schultze, J.L.~ and Matzaraki, V.~ and van der Ven, A.J.A.M.~ and Netea, M.G.~}, title = {Persistent Viral Control Status Is Associated with Enhanced Innate Immune Responses in People with HIV-1.}, journal = {iScience}, year = {2026}, volume = {29}, number = {3}, pages = {114807}, doi = {10.1016/j.isci.2026.114807}, url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-105030614301\&doi=10.1016%2fj.isci.2026.114807\&partnerID=40\&md5=cfd54c1c82c1297e5e133a27f65a11cd} } - Sidiropoulou C., Poulakou G., Kyriazopoulou E., Tasouli E., Giannitsioti E., Strikou A., Tsilika M., Christaki E., Rapti V., Evangelopoulou V., Rovina N., Iannotti N., Nicastri E., Taddei E., Florou H., Angheben A., Bassetti M., Dagna L., Torres A., Foutadakis S., Adamis G., Stylianakis E., Vatsellas G., Damoraki G., Efstratiou L., Damoulari C., Leventogiannis K., Laskaratos A., Koufargyris P., Charalampaki N., Chra P., Galanopoulou A., Thanos D., Panagopoulos P., Syrigos K., Ziogas A., Ter Horst R., van der Meer J.W.M., Iliopoulou K., Serino F.S., Pavlaki M., Del Vecchio P., Scorzolini L., Bandera A., Bakakos A., Sympardi S., Milionis H., Netea M.G., Giamarellos-Bourboulis E.J.
Long-Term Immune and Epigenetic Dysregulation Following COVID-19.
Clinical Immunology 283:110656, (2026) [bib]
@ARTICLE{sidiropoulou2026lied110656, author = {Sidiropoulou, C.~ and Poulakou, G.~ and Kyriazopoulou, E.~ and Tasouli, E.~ and Giannitsioti, E.~ and Strikou, A.~ and Tsilika, M.~ and Christaki, E.~ and Rapti, V.~ and Evangelopoulou, V.~ and Rovina, N.~ and Iannotti, N.~ and Nicastri, E.~ and Taddei, E.~ and Florou, H.~ and Angheben, A.~ and Bassetti, M.~ and Dagna, L.~ and Torres, A.~ and Foutadakis, S.~ and Adamis, G.~ and Stylianakis, E.~ and Vatsellas, G.~ and Damoraki, G.~ and Efstratiou, L.~ and Damoulari, C.~ and Leventogiannis, K.~ and Laskaratos, A.~ and Koufargyris, P.~ and Charalampaki, N.~ and Chra, P.~ and Galanopoulou, A.~ and Thanos, D.~ and Panagopoulos, P.~ and Syrigos, K.~ and Ziogas, A.~ and Ter Horst, R.~ and van der Meer, J.W.M.~ and Iliopoulou, K.~ and Serino, F.S.~ and Pavlaki, M.~ and Del Vecchio, P.~ and Scorzolini, L.~ and Bandera, A.~ and Bakakos, A.~ and Sympardi, S.~ and Milionis, H.~ and Netea, M.G.~ and Giamarellos-Bourboulis, E.J.~}, title = {Long-Term Immune and Epigenetic Dysregulation Following COVID-19.}, journal = {Clinical Immunology}, year = {2026}, volume = {283}, pages = {110656}, issn = {1521-7035 1521-6616}, doi = {10.1016/j.clim.2025.110656}, keywords = {Adult;Female;Humans;Male;Aged;Middle Aged;Prospective Studies;Phenotype;Cytokines;*COVID-19/immunology/genetics;*Epigenesis;Genetic/immunology;*SARS-CoV-2/immunology;Cytokines/blood/immunology/genetics;IL-1;Immune dysregulation;Lung function tests;Phenotypes;Post-Acute COVID-19 Syndrome;Post-acute COVID-19 syndrome (PACS)} }
2025
- Teufel L.U., Matzaraki V., Folkman L., de Graaf D.M., Ter Horst R., Moorlag S.J.C.F.M., Dos Santos J.C., Mulders-Manders C.M., Krausgruber T., Dinarello C., Netea M.G., Joosten L.A.B., Arts R.J.W.
Interleukin-38 Is a Negative Regulator of Trained Immunity—A Retrospective Multi-Omics Study.
iScience 28(11):113758, (2025) [bib]
@ARTICLE{teufel2025iian113758, author = {Teufel, L.U.~ and Matzaraki, V.~ and Folkman, L.~ and de Graaf, D.M.~ and Ter Horst, R.~ and Moorlag, S.J.C.F.M.~ and Dos Santos, J.C.~ and Mulders-Manders, C.M.~ and Krausgruber, T.~ and Dinarello, C.~ and Netea, M.G.~ and Joosten, L.A.B.~ and Arts, R.J.W.~}, title = {Interleukin-38 Is a Negative Regulator of Trained Immunity—A Retrospective Multi-Omics Study.}, journal = {iScience}, year = {2025}, volume = {28}, number = {11}, pages = {113758}, issn = {2589-0042}, doi = {10.1016/j.isci.2025.113758}, keywords = {Immune response;Immunity;Omics} } - Helder L.S., Groh L.A., Matzaraki V., Ter Horst R., Scheffer G.J., Joosten L.A.B., Netea M.G., Ferreira A.V.
Bacillus Calmette-Guérin-Induced Trained Immunity Potentiates TH17 Responses in Vitro.
Journal of Leukocyte Biology 117(9):qiaf123, (2025) [bib]
@ARTICLE{helder2025bctiqiaf123, author = {Helder, L.S.~ and Groh, L.A.~ and Matzaraki, V.~ and Ter Horst, R.~ and Scheffer, G.J.~ and Joosten, L.A.B.~ and Netea, M.G.~ and Ferreira, A.V.~}, title = {Bacillus Calmette-Guérin-Induced Trained Immunity Potentiates TH17 Responses in Vitro.}, journal = {Journal of Leukocyte Biology}, year = {2025}, volume = {117}, number = {9}, pages = {qiaf123}, issn = {1938-3673 0741-5400}, doi = {10.1093/jleuko/qiaf123}, keywords = {Humans;Cells;Cultured;T cells;vaccination;trained immunity;macrophages;BCG;Trained Immunity;*BCG Vaccine/immunology/pharmacology;*Macrophages/immunology;*Mycobacterium bovis/immunology;*Th17 Cells/immunology/cytology;Antigen Presentation;Coculture Techniques;Immunity;Innate;Interferon-gamma;Interleukin-17/biosynthesis;Lymphocyte Activation/immunology} } - Cabrera-Serrano A.J., Ruiz-Durán L., Gutiérrez-Bautista J.F., Carretero-Fernández M., Ter Horst R., Li Y., Reyes-Zurita F.J., García-Verdejo F.J., Netea M.G., Sánchez-Rovira P., López-Nevot M.Á., Sampedro A., Sainz J.
A Genome-Wide Association Study Identifies New Loci Associated with Response to SARS-CoV-2 mRNA-1273 Vaccine in a Cohort of Healthy Healthcare Workers.
Frontiers in Immunology 16:1639825, (2025) [bib]
@ARTICLE{cabreraserrano2025agas1639825, author = {Cabrera-Serrano, A.J.~ and Ruiz-Durán, L.~ and Gutiérrez-Bautista, J.F.~ and Carretero-Fernández, M.~ and Ter Horst, R.~ and Li, Y.~ and Reyes-Zurita, F.J.~ and García-Verdejo, F.J.~ and Netea, M.G.~ and Sánchez-Rovira, P.~ and López-Nevot, M.Á.~ and Sampedro, A.~ and Sainz, J.~}, title = {A Genome-Wide Association Study Identifies New Loci Associated with Response to SARS-CoV-2 mRNA-1273 Vaccine in a Cohort of Healthy Healthcare Workers.}, journal = {Frontiers in Immunology}, year = {2025}, volume = {16}, pages = {1639825}, issn = {1664-3224}, doi = {10.3389/fimmu.2025.1639825}, keywords = {Adult;Female;Humans;Male;Middle Aged;Cohort Studies;GWAS;Polymorphism;Single Nucleotide;Genome-Wide Association Study;Vaccination;Genetic Loci;Health Personnel;Immunoglobulin G/blood/immunology;SARS-CoV-2;*SARS-CoV-2/immunology;*COVID-19 Vaccines/immunology;*COVID-19/prevention \& control/immunology/genetics;2019-nCoV Vaccine mRNA-1273/immunology;Antibodies;Viral/blood/immunology;circulating IgG levels;genetic variants;IgG decay;Spike Glycoprotein;Coronavirus/immunology} } - Zhang Z., Li W., Zhan Q., Aillaud M., Botey-Bataller J., Zoodsma M., Ter Horst R., Joosten L.A.B., Bock C., Schulte L.N., Xu C.-J., Netea M.G., Bonder M.J., Li Y.
Unveiling Genetic Signatures of Immune Response in Immune-Related Diseases through Single-Cell eQTL Analysis across Diverse Conditions.
Nature Communications 16:7134, (2025) [bib]
@ARTICLE{zhang2025ugsi7134, author = {Zhang, Z.~ and Li, W.~ and Zhan, Q.~ and Aillaud, M.~ and Botey-Bataller, J.~ and Zoodsma, M.~ and Ter Horst, R.~ and Joosten, L.A.B.~ and Bock, C.~ and Schulte, L.N.~ and Xu, C.-J.~ and Netea, M.G.~ and Bonder, M.J.~ and Li, Y.~}, title = {Unveiling Genetic Signatures of Immune Response in Immune-Related Diseases through Single-Cell eQTL Analysis across Diverse Conditions.}, journal = {Nature Communications}, year = {2025}, volume = {16}, pages = {7134}, doi = {10.1038/s41467-025-61192-4} }
2024
- Teufel L.U., Matzaraki V., Folkman L., Ter Horst R., Moorlag S.J.C.F.M., Mulders-Manders C.M., Netea M.G., Krausgruber T., Joosten L.A.B., Arts R.J.W.
Insights into the Multifaceted Role of Interleukin-37 on Human Immune Cell Regulation.
Clinical Immunology 268:110368, (2024) [bib]
@ARTICLE{teufel2024iimr110368, author = {Teufel, L.U.~ and Matzaraki, V.~ and Folkman, L.~ and Ter Horst, R.~ and Moorlag, S.J.C.F.M.~ and Mulders-Manders, C.M.~ and Netea, M.G.~ and Krausgruber, T.~ and Joosten, L.A.B.~ and Arts, R.J.W.~}, title = {Insights into the Multifaceted Role of Interleukin-37 on Human Immune Cell Regulation.}, journal = {Clinical Immunology}, year = {2024}, volume = {268}, pages = {110368}, issn = {1521-7035 1521-6616}, doi = {10.1016/j.clim.2024.110368}, keywords = {Inflammation;Autoinflammation;BCG;Interleukin (IL)-37;Trained immunity} } - Schaefer M., Reichl S., Ter Horst R., Nicolas A.M., Krausgruber T., Piras F., Stepper P., Bock C., Samwald M.
GPT-4 as a Biomedical Simulator.
Computers in Biology and Medicine 178:108796, (2024) [bib]
@ARTICLE{schaefer2024gaab108796, author = {Schaefer, M.~ and Reichl, S.~ and Ter Horst, R.~ and Nicolas, A.M.~ and Krausgruber, T.~ and Piras, F.~ and Stepper, P.~ and Bock, C.~ and Samwald, M.~}, title = {GPT-4 as a Biomedical Simulator.}, journal = {Computers in Biology and Medicine}, year = {2024}, volume = {178}, pages = {108796}, issn = {1879-0534 0010-4825}, doi = {10.1016/j.compbiomed.2024.108796}, keywords = {Artificial intelligence;Computational biology;Large language models;Biomedical simulation;GPT-4} } - Moorlag S.J.C.F.M., Folkman L., Ter Horst R., Krausgruber T., Barreca D., Schuster L.C., Fife V., Matzaraki V., Li W., Reichl S., Mourits V.P., Koeken V.A.C.M., de Bree L.C.J., Dijkstra H., Lemmers H., van Cranenbroek B., van Rijssen E., Koenen H.J.P.M., Joosten I., Xu C.-J., Li Y., Joosten L.A.B., van Crevel R., Netea M.G., Bock C.
Multi-Omics Analysis of Innate and Adaptive Responses to BCG Vaccination Reveals Epigenetic Cell States That Predict Trained Immunity.
Immunity 57(1), 171–187.e14, (2024) [bib]
@ARTICLE{moorlag2024maia171187e14, author = {Moorlag, S.J.C.F.M.~ and Folkman, L.~ and Ter Horst, R.~ and Krausgruber, T.~ and Barreca, D.~ and Schuster, L.C.~ and Fife, V.~ and Matzaraki, V.~ and Li, W.~ and Reichl, S.~ and Mourits, V.P.~ and Koeken, V.A.C.M.~ and de Bree, L.C.J.~ and Dijkstra, H.~ and Lemmers, H.~ and van Cranenbroek, B.~ and van Rijssen, E.~ and Koenen, H.J.P.M.~ and Joosten, I.~ and Xu, C.-J.~ and Li, Y.~ and Joosten, L.A.B.~ and van Crevel, R.~ and Netea, M.G.~ and Bock, C.~}, title = {Multi-Omics Analysis of Innate and Adaptive Responses to BCG Vaccination Reveals Epigenetic Cell States That Predict Trained Immunity.}, journal = {Immunity}, year = {2024}, volume = {57}, number = {1}, pages = {171--187.e14}, doi = {10.1016/j.immuni.2023.12.005} }
2022
- Vos W.A.J.W., Groenendijk A.L., Blaauw M.J.T., van Eekeren L.E., Navas A., Cleophas M.C.P., Vadaq N., Matzaraki V., Dos Santos J.C., Meeder E.M.G., Fröberg J., Weijers G., Zhang Y., Fu J., Ter Horst R., Bock C., Knoll R., Aschenbrenner A.C., Schultze J., Vanderkerckhove L., Hwandih T., Wonderlich E.R., Vemula S.V., van der Kolk M., de Vet S.C.P., Blok W.L., Brinkman K., Rokx C., Schellekens A.F.A., de Mast Q., Joosten L.A.B., Berrevoets M.A.H., Stalenhoef J.E., Verbon A., van Lunzen J., Netea M.G., van der Ven A.J.A.M.
The 2000HIV Study: Design, Multi-Omics Methods and Participant Characteristics.
Frontiers in Immunology 13:982746, (2022) [bib]
@ARTICLE{vos20222sdm982746, author = {Vos, W.A.J.W.~ and Groenendijk, A.L.~ and Blaauw, M.J.T.~ and van Eekeren, L.E.~ and Navas, A.~ and Cleophas, M.C.P.~ and Vadaq, N.~ and Matzaraki, V.~ and Dos Santos, J.C.~ and Meeder, E.M.G.~ and Fr{\"o}berg, J.~ and Weijers, G.~ and Zhang, Y.~ and Fu, J.~ and Ter Horst, R.~ and Bock, C.~ and Knoll, R.~ and Aschenbrenner, A.C.~ and Schultze, J.~ and Vanderkerckhove, L.~ and Hwandih, T.~ and Wonderlich, E.R.~ and Vemula, S.V.~ and van der Kolk, M.~ and de Vet, S.C.P.~ and Blok, W.L.~ and Brinkman, K.~ and Rokx, C.~ and Schellekens, A.F.A.~ and de Mast, Q.~ and Joosten, L.A.B.~ and Berrevoets, M.A.H.~ and Stalenhoef, J.E.~ and Verbon, A.~ and van Lunzen, J.~ and Netea, M.G.~ and van der Ven, A.J.A.M.~}, title = {The 2000HIV Study: Design, Multi-Omics Methods and Participant Characteristics.}, journal = {Frontiers in Immunology}, year = {2022}, volume = {13}, pages = {982746}, issn = {1664-3224}, doi = {10.3389/fimmu.2022.982746}, keywords = {COVID-19;HIV-1;cardiovascular disease;hepatic disease;HIV extreme phenotype;HIV reservoir;multi-omics;non-AIDS comorbidities} }