Biometric Colloquium
Cyrus Mehta
Cyrus Mehta, President and Co-founder of Cytel Inc. Adjunct Professor,
Department of Biostatistics, Harvard T.H. Chan School of Public Health
Flexible adaptive procedures for testing multiple treatments, endpoints or populations in confirmatory clinical trials
March 4th, 2026 at 09:15 am
Seminarraum Center for Medical Data Science (previously CeMSIIS),
Spitalgasse 23, Room 88.03.512
Medical University of Vienna, 1090 Wien
Hosts: Franz König and Martin Posch
Abstract:
priorities for hierarchical testing of multiple hypotheses, and for propagating the available
type-1 error from rejected or dropped hypotheses to hypotheses yet to be tested. Although
originally developed for single stage non-adaptive designs, we show how it may be extended
to two-stage designs that permit early identification of efficacious treatments, adaptive
sample size re-estimation, dropping of hypotheses, and changes in the hierarchical testing
strategy at the end of stage one. We will present the statistical methodology for controlling
the family wise error rate in the presence of these adaptive changes, and will generate the
operating characteristics of different underlying scenarios and adaptive decision rules
through a large simulation experiment.