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Publications

Publications by Rudolf Karch

2023

  • Schreiner W., Karch R., Cibena M., Tomasiak L., Kenn M., Pfeiler G.
    Clustering Molecular Dynamics Conformations of the CC’-Loop of the PD-1 Immuno-Checkpoint Receptor.
    Computational and Structural Biotechnology Journal 21, 3920–3932, (2023) [bib]
    
    @ARTICLE{schreiner2023cmdc39203932,
      author = {Schreiner, W.~ and Karch, R.~ and Cibena, M.~ and Tomasiak, L.~ and Kenn, M.~ and Pfeiler, G.~},
      title = {Clustering Molecular Dynamics Conformations of the CC’-Loop of the PD-1 Immuno-Checkpoint Receptor.},
      journal = {Computational and Structural Biotechnology Journal},
      year = {2023},
      volume = {21},
      pages = {3920--3932},
      doi = {10.1016/j.csbj.2023.07.004}
    }
  • Kenn M., Karch R., Singer C.F., Dorffner G., Schreiner W.
    Flexible Risk Evidence Combination Rules in Breast Cancer Precision Therapy.
    Journal of Personalized Medicine 13(1):119, (2023) [bib]
    
    @ARTICLE{kenn2023frec119,
      author = {Kenn, M.~ and Karch, R.~ and Singer, C.F.~ and Dorffner, G.~ and Schreiner, W.~},
      title = {Flexible Risk Evidence Combination Rules in Breast Cancer Precision Therapy.},
      journal = {Journal of Personalized Medicine},
      year = {2023},
      volume = {13},
      number = {1},
      pages = {119},
      issn = {2075-4426},
      doi = {10.3390/jpm13010119},
      keywords = {precision medicine;personalized medicine;data science;breast cancer;mathematical oncology;Dempster-Shafer theory;evidence theory;hormone receptor status;theory of belief functions}
    }

2022

  • Schreiner W., Karch R., Cibena M., Tomasiak L., Kenn M., Pfeiler G.
    The Performance of UMAP Plus Linkage Compared with Daura-Clustering of Molecular Dynamics of the PD-1 Checkpoint Receptor.
    In Adjeroh D., Long Q., Shi X., Guo F., Hu X., Aluru S., Narasimhan G., Wang J., Kang M., Mondal A.M., Liu J. (Eds.) Proceedings 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Las Vegas, USA & Changsha, China, 6–8 December 2022, Institute of Electrical and Electronics Engineers (IEEE), Piscataway, NJ, 3569–3573, (2022) [bib]
    
    @INCOLLECTION{schreiner2022pupl35693573,
      author = {Schreiner, W.~ and Karch, R.~ and Cibena, M.~ and Tomasiak, L.~ and Kenn, M.~ and Pfeiler, G.~},
      title = {The Performance of UMAP Plus Linkage Compared with Daura-Clustering of Molecular Dynamics of the PD-1 Checkpoint Receptor.},
      booktitle = {Proceedings 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Las Vegas, USA \& Changsha, China, 6–8 December 2022},
      publisher = {Institute of Electrical and Electronics Engineers (IEEE)},
      year = {2022},
      editor = {Adjeroh,D.;Long,Q.;Shi,X.;Guo,F.;Hu,X.;Aluru,S.;Narasimhan,G.;Wang,J.;Kang,M.;Mondal,A.M.;Liu,J.},
      pages = {3569--3573},
      address = {Piscataway, NJ},
      month = {dec},
      url = {https://www.doi.org/10.1109/BIBM55620.2022.9995272}
    }
  • Kenn M., Karch R., Tomasiak L., Cibena M., Pfeiler G., Koelbl H., Schreiner W.
    Molecular Dynamics Identifies Semi-Rigid Domains in the PD-1 Checkpoint Receptor Bound to Its Natural Ligand PD-L1.
    Frontiers in Bioengineering and Biotechnology 10:838129, (2022) [bib]
    
    @ARTICLE{kenn2022mdis838129,
      author = {Kenn, M.~ and Karch, R.~ and Tomasiak, L.~ and Cibena, M.~ and Pfeiler, G.~ and Koelbl, H.~ and Schreiner, W.~},
      title = {Molecular Dynamics Identifies Semi-Rigid Domains in the PD-1 Checkpoint Receptor Bound to Its Natural Ligand PD-L1.},
      journal = {Frontiers in Bioengineering and Biotechnology},
      year = {2022},
      volume = {10},
      pages = {838129},
      issn = {2296-4185},
      doi = {10.3389/fbioe.2022.838129},
      keywords = {molecular dynamics;oncology;checkpoint inhibitor;cluster analysis;drug design;immune therapy}
    }
  • Tomasiak L., Karch R., Schreiner W.
    Conformational Flexibility of a Free and TCR-Bound pMHC-I Protein Investigated by Long-Term Molecular Dynamics Simulations.
    BMC Immunology 23(Suppl 1: Selected Papers 4th International Workshop on Computational Methods for the Immune System Function (CMISF 2020): Immunology, Virtual, 16–19 December 2020):36, (2022) [bib]
    
    @ARTICLE{tomasiak2022cfaf36,
      author = {Tomasiak, L.~ and Karch, R.~ and Schreiner, W.~},
      title = {Conformational Flexibility of a Free and TCR-Bound pMHC-I Protein Investigated by Long-Term Molecular Dynamics Simulations.},
      journal = {BMC Immunology},
      year = {2022},
      volume = {23},
      number = {Suppl 1: Selected Papers 4th International Workshop on Computational Methods for the Immune System Function (CMISF 2020): Immunology, Virtual, 16–19 December 2020},
      pages = {36},
      doi = {10.1186/s12865-022-00510-7}
    }
  • Kenn M., Karch R., Cacsire Castillo-Tong D., Singer C.F., Koelbl H., Schreiner W.
    Decision Theory versus Conventional Statistics for Personalized Therapy of Breast Cancer.
    Journal of Personalized Medicine 12(4):570, (2022) [bib]
    
    @ARTICLE{kenn2022dtvc570,
      author = {Kenn, M.~ and Karch, R.~ and Cacsire Castillo-Tong, D.~ and Singer, C.F.~ and Koelbl, H.~ and Schreiner, W.~},
      title = {Decision Theory versus Conventional Statistics for Personalized Therapy of Breast Cancer.},
      journal = {Journal of Personalized Medicine},
      year = {2022},
      volume = {12},
      number = {4},
      pages = {570},
      issn = {2075-4426},
      doi = {10.3390/jpm12040570},
      keywords = {precision medicine;biomarkers;personalized medicine;data science;breast cancer;gene expression;mathematical oncology;receptor status;decision theory}
    }

2021

  • Hernández-Lozano I., Wanek T., Sauberer M., Filip T., Mairinger S., Stanek J., Traxl A., Karch R., Schuetz J.D., Langer O.
    Influence of ABC Transporters on the Excretion of Ciprofloxacin Assessed with PET Imaging in Mice.
    European Journal of Pharmaceutical Sciences 163:105854, (2021) [bib]
    
    @ARTICLE{hernándezlozano2021iate105854,
      author = {Hernández-Lozano, I.~ and Wanek, T.~ and Sauberer, M.~ and Filip, T.~ and Mairinger, S.~ and Stanek, J.~ and Traxl, A.~ and Karch, R.~ and Schuetz, J.D.~ and Langer, O.~},
      title = {Influence of ABC Transporters on the Excretion of Ciprofloxacin Assessed with PET Imaging in Mice.},
      journal = {European Journal of Pharmaceutical Sciences},
      year = {2021},
      volume = {163},
      pages = {105854},
      issn = {1879-0720 0928-0987},
      doi = {10.1016/j.ejps.2021.105854},
      keywords = {Positron emission tomography;[(18)F]Ciprofloxacin;Breast cancer resistance protein (BCRP);Multidrug resistance-associated protein 4 (MRP4);Pharmacokinetic modelling;Tubular secretion}
    }
  • El Biali M., Karch R., Philippe C., Haslacher H., Tournier N., Hacker M., Zeitlinger M., Schmidl D., Langer O., Bauer M.
    ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure.
    Frontiers in Pharmacology 12:698966, (2021) [bib]
    
    @ARTICLE{elbiali2021aatl698966,
      author = {El Biali, M.~ and Karch, R.~ and Philippe, C.~ and Haslacher, H.~ and Tournier, N.~ and Hacker, M.~ and Zeitlinger, M.~ and Schmidl, D.~ and Langer, O.~ and Bauer, M.~},
      title = {ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure.},
      journal = {Frontiers in Pharmacology},
      year = {2021},
      volume = {12},
      pages = {698966},
      issn = {1663-9812},
      doi = {10.3389/fphar.2021.698966},
      keywords = {human;PET;tariquidar;single-nucleotide polymorphism;ABCB1;ABCG2;blood-retinal barrier;c421C{	extgreater}A}
    }
  • Kenn M, Cacsire Castillo-Tong D., Singer C.F., Karch R., Cibena M., Kölbl H., Schreiner W.
    Evidenz statt Wahrscheinlichkeiten: Entscheidungstheorie für die Präzisionsmedizin.
    Spectrum Onkologie 2/2021, 70–72, (2021) [bib]
    
    @ARTICLE{kenn2021eswe7072,
      author = {Kenn, M~ and Cacsire Castillo-Tong, D.~ and Singer, C.F.~ and Karch, R.~ and Cibena, M.~ and K{\"o}lbl, H.~ and Schreiner, W.~},
      title = {Evidenz statt Wahrscheinlichkeiten: Entscheidungstheorie f{\"u}r die Pr{\"a}zisionsmedizin.},
      journal = {Spectrum Onkologie},
      year = {2021},
      volume = {2/2021},
      pages = {70--72},
      url = {https://www.medmedia.at/apps/download/download_pdf.php?file=wp-content/uploads/2021/04/so-2021-02-lr.pdf#page=70}
    }
  • Kenn M., Cacsire Castillo-Tong D., Singer C.F., Karch R., Cibena M., Koelbl H., Schreiner W.
    Decision Theory for Precision Therapy of Breast Cancer.
    Scientific Reports 11:4233, (2021) [bib]
    
    @ARTICLE{kenn2021dtpt4233,
      author = {Kenn, M.~ and Cacsire Castillo-Tong, D.~ and Singer, C.F.~ and Karch, R.~ and Cibena, M.~ and Koelbl, H.~ and Schreiner, W.~},
      title = {Decision Theory for Precision Therapy of Breast Cancer.},
      journal = {Scientific Reports},
      year = {2021},
      volume = {11},
      pages = {4233},
      issn = {2045-2322},
      doi = {10.1038/s41598-021-82418-7}
    }

2020

  • Tomasiak L., Karch R., Schreiner W.
    Long-Term Molecular Dynamics Simulations Reveal Flexibility Properties of a Free and TCR-Bound pMHC-I System.
    In Park T., Cho Y.-R., Hu X., Yoo I., Woo H.G., Wang J., Facelli J., Nam S., Kang M. (Eds.) Proceedings 2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Seoul, Korea, 16–19 December 2020, IEEE, Piscataway, NJ, 1295–1302, (2020) [bib]
    
    @INPROCEEDINGS{tomasiak2020lmds12951302,
      author = {Tomasiak, L.~ and Karch, R.~ and Schreiner, W.~},
      title = {Long-Term Molecular Dynamics Simulations Reveal Flexibility Properties of a Free and TCR-Bound pMHC-I System.},
      booktitle = {Proceedings 2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Seoul, Korea, 16–19 December 2020},
      year = {2020},
      editor = {Park,T.;Cho,Y.-R.;Hu,X.;Yoo,I.;Woo,H.G.;Wang,J.;Facelli,J.;Nam,S.;Kang,M.},
      pages = {1295--1302},
      address = {Piscataway, NJ},
      publisher = {IEEE},
      doi = {10.1109/BIBM49941.2020.9313545},
      url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100345478\&doi=10.1109%2fBIBM49941.2020.9313545\&partnerID=40\&md5=2948b457d9ecfeba2799c184a625635b}
    }
  • Buchtele N., Schwameis M., Schoergenhofer C., Derhaschnig U., Firbas C., Karch R., Nix D., Schenk R., Jilma B.
    Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Parenterally Administered Dutogliptin: A Prospective Dose-Escalating Trial.
    British Journal of Clinical Pharmacology 86(5), 979–990, (2020) [bib]
    
    @ARTICLE{buchtele2020stpp979990,
      author = {Buchtele, N.~ and Schwameis, M.~ and Schoergenhofer, C.~ and Derhaschnig, U.~ and Firbas, C.~ and Karch, R.~ and Nix, D.~ and Schenk, R.~ and Jilma, B.~},
      title = {Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Parenterally Administered Dutogliptin: A Prospective Dose-Escalating Trial.},
      journal = {British Journal of Clinical Pharmacology},
      year = {2020},
      volume = {86},
      number = {5},
      pages = {979--990},
      issn = {0306-5251},
      doi = {10.1111/bcp.14208},
      url = {https://doi.org/10.1111/bcp.14208},
      keywords = {dutogliptin;healthy;parenteral;pharmacokinetics/pharmacodynamics;safety}
    }

2019

  • Wulkersdorfer B., Bauer M., Karch R., Stefanits H., Philippe C., Weber M., Czech T., Menet M.-C., Declèves X., Hainfellner J.A., Preusser M., Hacker M., Zeitlinger M., Müller M., Langer O.
    Assessment of Brain Delivery of a Model ABCB1/ABCG2 Substrate in Patients with Non-Contrast-Enhancing Brain Tumors with Positron Emission Tomography.
    EJNMMI Research 9:110, (2019) [bib]
    
    @ARTICLE{wulkersdorfer2019abda110,
      author = {Wulkersdorfer, B.~ and Bauer, M.~ and Karch, R.~ and Stefanits, H.~ and Philippe, C.~ and Weber, M.~ and Czech, T.~ and Menet, M.-C.~ and Declèves, X.~ and Hainfellner, J.A.~ and Preusser, M.~ and Hacker, M.~ and Zeitlinger, M.~ and M{\"u}ller, M.~ and Langer, O.~},
      title = {Assessment of Brain Delivery of a Model ABCB1/ABCG2 Substrate in Patients with Non-Contrast-Enhancing Brain Tumors with Positron Emission Tomography.},
      journal = {EJNMMI Research},
      year = {2019},
      volume = {9},
      pages = {110},
      doi = {10.1186/s13550-019-0581-y},
      url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076350408\&doi=10.1186%2fs13550-019-0581-y\&partnerID=40\&md5=51e3132dea24ea67d80b0b1a079ed8d8}
    }
  • Karch R., Stocsits C., Ilieva N., Schreiner W.
    Intramolecular Domain Movements of Free and Bound pMHC and TCR Proteins: A Molecular Dynamics Simulation Study.
    Cells 8(7):720, (2019) [bib]
    
    @ARTICLE{karch2019idmf720,
      author = {Karch, R.~ and Stocsits, C.~ and Ilieva, N.~ and Schreiner, W.~},
      title = {Intramolecular Domain Movements of Free and Bound pMHC and TCR Proteins: A Molecular Dynamics Simulation Study.},
      journal = {Cells},
      year = {2019},
      volume = {8},
      number = {7},
      pages = {720},
      issn = {2073-4409 2073-4409},
      doi = {10.3390/cells8070720},
      keywords = {Humans;*antigen;*domain movements;*major histocompatibility complex;*Major Histocompatibility Complex;*molecular dynamics simulation;*T-cell receptor;Binding Sites;Molecular Dynamics Simulation;Peptides/*chemistry;Protein Binding;Protein Conformation;Receptors;Antigen;T-Cell;alpha-beta/*chemistry}
    }
  • Hernández Lozano I., Karch R., Bauer M., Blaickner M., Matsuda A., Wulkersdorfer B., Hacker M., Zeitlinger M., Langer O.
    Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography.
    AAPS Journal 21(4):61, (2019) [bib]
    
    @ARTICLE{hernándezlozano2019tipm61,
      author = {Hernández Lozano, I.~ and Karch, R.~ and Bauer, M.~ and Blaickner, M.~ and Matsuda, A.~ and Wulkersdorfer, B.~ and Hacker, M.~ and Zeitlinger, M.~ and Langer, O.~},
      title = {Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography.},
      journal = {AAPS Journal},
      year = {2019},
      volume = {21},
      number = {4},
      pages = {61},
      doi = {10.1208/s12248-019-0323-0},
      url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065136123\&doi=10.1208%2fs12248-019-0323-0\&partnerID=40\&md5=28c8d4906aa021eed9c80f8bf4d0dde5}
    }
  • Tournier N., Bauer M., Pichler V., Nics L., Klebermass E.-M., Bamminger K., Matzneller P., Weber M., Karch R., Caillé F., Auvity S., Marie S., Jäger W., Wadsak W., Hacker M., Zeitlinger M., Langer O.
    Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate 11C-Metoclopramide Assessed with PET Imaging in Humans.
    Journal of Nuclear Medicine 60(7), 985–991, (2019) [bib]
    
    @ARTICLE{tournier2019ipfb985991,
      author = {Tournier, N.~ and Bauer, M.~ and Pichler, V.~ and Nics, L.~ and Klebermass, E.-M.~ and Bamminger, K.~ and Matzneller, P.~ and Weber, M.~ and Karch, R.~ and Caillé, F.~ and Auvity, S.~ and Marie, S.~ and J{\"a}ger, W.~ and Wadsak, W.~ and Hacker, M.~ and Zeitlinger, M.~ and Langer, O.~},
      title = {Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate 11C-Metoclopramide Assessed with PET Imaging in Humans.},
      journal = {Journal of Nuclear Medicine},
      year = {2019},
      volume = {60},
      number = {7},
      pages = {985--991},
      issn = {1535-5667 0161-5505},
      doi = {10.2967/jnumed.118.219972},
      keywords = {11C-metoclopramide;blood-brain barrier;P-glycoprotein;PET}
    }
  • Bauer M., Karch R., Wulkersdorfer B., Philippe C., Nics L., Klebermass E.-M., Weber M., Poschner S., Haslacher H., Jäger W., Tournier N., Wadsak W., Hacker M., Zeitlinger M., Langer O.
    A Proof-of-Concept Study to Inhibit ABCG2- and ABCB1-Mediated Efflux Transport at the Human Blood-Brain Barrier.
    Journal of Nuclear Medicine 60(4), 486–491, (2019) [bib]
    
    @ARTICLE{bauer2019apst486491,
      author = {Bauer, M.~ and Karch, R.~ and Wulkersdorfer, B.~ and Philippe, C.~ and Nics, L.~ and Klebermass, E.-M.~ and Weber, M.~ and Poschner, S.~ and Haslacher, H.~ and J{\"a}ger, W.~ and Tournier, N.~ and Wadsak, W.~ and Hacker, M.~ and Zeitlinger, M.~ and Langer, O.~},
      title = {A Proof-of-Concept Study to Inhibit ABCG2- and ABCB1-Mediated Efflux Transport at the Human Blood-Brain Barrier.},
      journal = {Journal of Nuclear Medicine},
      year = {2019},
      volume = {60},
      number = {4},
      pages = {486--491},
      issn = {1535-5667 0161-5505},
      doi = {10.2967/jnumed.118.216432},
      keywords = {blood-brain barrier;P-glycoprotein;PET;11C-erlotinib;breast cancer resistance protein}
    }
  • Simeone X., Karch R., Ciuraszkiewicz A., Orr-Urtreger A., Lemmens-Gruber R., Scholze P., Huck S.
    The Role of the nAChR Subunits α5, β2, and β4 on Synaptic Transmission in the Mouse Superior Cervical Ganglion.
    Physiological Reports 7(6):e14023, (2019) [bib]
    
    @ARTICLE{simeone2019rns5e14023,
      author = {Simeone, X.~ and Karch, R.~ and Ciuraszkiewicz, A.~ and Orr-Urtreger, A.~ and Lemmens-Gruber, R.~ and Scholze, P.~ and Huck, S.~},
      title = {The Role of the nAChR Subunits α5, β2, and β4 on Synaptic Transmission in the Mouse Superior Cervical Ganglion.},
      journal = {Physiological Reports},
      year = {2019},
      volume = {7},
      number = {6},
      pages = {e14023},
      issn = {2051-817X 2051-817X},
      doi = {10.14814/phy2.14023},
      keywords = {* EPSP;*Compound action potential;*Hexamethonium;*knockout mice;*nicotinic ACh receptor;*superior cervical ganglion;*synaptic transmission}
    }

2018

  • Bauer M., Traxl A., Matsuda A., Karch R., Philippe C., Nics L., Klebermass E.-M., Wulkersdorfer B., Weber M., Poschner S., Tournier N., Jäger W., Wadsak W., Hacker M., Wanek T., Zeitlinger M., Langer O.
    Effect of Rifampicin on the Distribution of [11C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice.
    Molecular Pharmaceutics 15(10), 4589–4598, (2018) [bib]
    
    @ARTICLE{bauer2018erd[45894598,
      author = {Bauer, M.~ and Traxl, A.~ and Matsuda, A.~ and Karch, R.~ and Philippe, C.~ and Nics, L.~ and Klebermass, E.-M.~ and Wulkersdorfer, B.~ and Weber, M.~ and Poschner, S.~ and Tournier, N.~ and J{\"a}ger, W.~ and Wadsak, W.~ and Hacker, M.~ and Wanek, T.~ and Zeitlinger, M.~ and Langer, O.~},
      title = {Effect of Rifampicin on the Distribution of [11C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice.},
      journal = {Molecular Pharmaceutics},
      year = {2018},
      volume = {15},
      number = {10},
      pages = {4589--4598},
      issn = {1543-8384},
      doi = {10.1021/acs.molpharmaceut.8b00588},
      url = {https://doi.org/10.1021/acs.molpharmaceut.8b00588}
    }

2017

  • Bauer M., Wulkersdorfer B., Karch R., Philippe C., Jäger W., Stanek J., Wadsak W., Hacker M., Zeitlinger M., Langer O.
    Effect of P-Glycoprotein Inhibition at the Blood–Brain Barrier on Brain Distribution of (R)-[11C]Verapamil in Elderly vs. Young Subjects.
    British Journal of Clinical Pharmacology 83(9), 1991–1999, (2017) [bib]
    
    @ARTICLE{bauer2017epia19911999,
      author = {Bauer, M.~ and Wulkersdorfer, B.~ and Karch, R.~ and Philippe, C.~ and J{\"a}ger, W.~ and Stanek, J.~ and Wadsak, W.~ and Hacker, M.~ and Zeitlinger, M.~ and Langer, O.~},
      title = {Effect of P-Glycoprotein Inhibition at the Blood–Brain Barrier on Brain Distribution of (R)-[11C]Verapamil in Elderly vs. Young Subjects.},
      journal = {British Journal of Clinical Pharmacology},
      year = {2017},
      volume = {83},
      number = {9},
      pages = {1991--1999},
      issn = {0306-5251},
      doi = {10.1111/bcp.13301},
      keywords = {age;alzheimers-disease;blood-brain barrier;P-glycoprotein;pet;positron-emission-tomography;drug-drug interactions;drug-drug interaction;epilepsy;pilot pet;resistance protein bcrp/abcg2;substrate;tariquidar;transporters}
    }
  • Matsuda A., Karch R., Bauer M., Traxl A., Zeitlinger M., Langer O.
    A Prediction Method for P-Glycoprotein–Mediated Drug–Drug Interactions at the Human Blood–Brain Barrier from Blood Concentration–Time Profiles, Validated with PET Data.
    Journal of Pharmaceutical Sciences 106(9), 2780–2786, (2017) [bib]
    
    @ARTICLE{matsuda2017apmp27802786,
      author = {Matsuda, A.~ and Karch, R.~ and Bauer, M.~ and Traxl, A.~ and Zeitlinger, M.~ and Langer, O.~},
      title = {A Prediction Method for P-Glycoprotein–Mediated Drug–Drug Interactions at the Human Blood–Brain Barrier from Blood Concentration–Time Profiles, Validated with PET Data.},
      journal = {Journal of Pharmaceutical Sciences},
      year = {2017},
      volume = {106},
      number = {9},
      pages = {2780--2786},
      issn = {0022-3549},
      doi = {10.1016/j.xphs.2017.03.024},
      keywords = {blood-brain barrier;P-glycoprotein;pet;positron-emission-tomography;tariquidar;transporters;ABC transporters;cancer resistance protein;clearance;drug-drug interactions;inhibition;multi;pharmacokinetics;physiologically based pharmacokinetic model;receptors;tissue distribution}
    }
  • Bauer M., Karch R., Tournier N., Cisternino S., Wadsak W., Hacker M., Marhofer P., Zeitlinger M., Langer O.
    Assessment of P-Glycoprotein Transport Activity at the Human Blood–Retina Barrier with (R)-11C-Verapamil PET.
    Journal of Nuclear Medicine 58(4), 678–681, (2017) [bib]
    
    @ARTICLE{bauer2017apta678681,
      author = {Bauer, M.~ and Karch, R.~ and Tournier, N.~ and Cisternino, S.~ and Wadsak, W.~ and Hacker, M.~ and Marhofer, P.~ and Zeitlinger, M.~ and Langer, O.~},
      title = {Assessment of P-Glycoprotein Transport Activity at the Human Blood–Retina Barrier with (R)-11C-Verapamil PET.},
      journal = {Journal of Nuclear Medicine},
      year = {2017},
      volume = {58},
      number = {4},
      pages = {678--681},
      issn = {0161-5505},
      doi = {10.2967/jnumed.116.182147},
      keywords = {blood-brain barrier;P-glycoprotein;binding;pet;inhibition;blood-retina barrier;brain-barrier;carrier;eye}
    }

2016

  • Bauer M., Römermann K., Karch R., Wulkersdorfer B., Stanek J., Philippe C., Maier-Salamon A., Haslacher H., Jungbauer C., Wadsak W., Jäger W., Löscher W., Hacker M., Zeitlinger M., Langer O.
    Pilot PET Study to Assess the Functional Interplay between ABCB1 and ABCG2 at the Human Blood–Brain Barrier.
    Clinical Pharmacology & Therapeutics 100(2), 131–141, (2016) [bib]
    
    @ARTICLE{bauer2016ppst131141,
      author = {Bauer, M.~ and R{\"o}mermann, K.~ and Karch, R.~ and Wulkersdorfer, B.~ and Stanek, J.~ and Philippe, C.~ and Maier-Salamon, A.~ and Haslacher, H.~ and Jungbauer, C.~ and Wadsak, W.~ and J{\"a}ger, W.~ and L{\"o}scher, W.~ and Hacker, M.~ and Zeitlinger, M.~ and Langer, O.~},
      title = {Pilot PET Study to Assess the Functional Interplay between ABCB1 and ABCG2 at the Human Blood–Brain Barrier.},
      journal = {Clinical Pharmacology \& Therapeutics},
      year = {2016},
      volume = {100},
      number = {2},
      pages = {131--141},
      issn = {0009-9236},
      doi = {10.1002/cpt.362},
      keywords = {positron-emission-tomography;cancer resistance protein;drug-drug interactions;inhibition;bcrp gene polymorphisms;efflux;p-glycoprotein activity;quantitative atlas;radiotracer;transport activity}
    }
  • Kenn M., Ribarics R., Ilieva N., Cibena M., Karch R., Schreiner W.
    Spatiotemporal Multistage Consensus Clustering in Molecular Dynamics Studies of Large Proteins.
    Molecular BioSystems 12(5), 1600–1614, (2016) [bib]
    
    @ARTICLE{kenn2016smcc16001614,
      author = {Kenn, M.~ and Ribarics, R.~ and Ilieva, N.~ and Cibena, M.~ and Karch, R.~ and Schreiner, W.~},
      title = {Spatiotemporal Multistage Consensus Clustering in Molecular Dynamics Studies of Large Proteins.},
      journal = {Molecular BioSystems},
      year = {2016},
      volume = {12},
      number = {5},
      pages = {1600--1614},
      issn = {1742-2051 1742-2051},
      doi = {10.1039/c5mb00879d},
      keywords = {Algorithms;Protein Conformation;*Cluster Analysis;*Molecular Dynamics Simulation;CD8 Antigens/chemistry/metabolism;Major Histocompatibility Complex;Models;Molecular;Multiprotein Complexes/chemistry;Protein Interaction Domains and Motifs;Proteins/*chemistry/metabolism;Receptors;Antigen;T-Cell/chemistry/metabolism}
    }
  • Bauer M., Feldmann M., Karch R., Zeitlinger M., Koepp M.J., Asselin M.-C., Pataraia E., Langer O.
    Outcome Prediction of Temporal Lobe Epilepsy Surgery from P-Glycoprotein Activity Pooled Analysis of (R)-[11C]-Verapamil PET Data from Two European Centres.
    EJNMMI Research 6(Suppl 1: Abstracts 32nd International Austrian Winter Symposium, Zell am See, Austria, 20–23 January 2016):A12, (2016) [bib]
    
    @ARTICLE{bauer2016optla12,
      author = {Bauer, M.~ and Feldmann, M.~ and Karch, R.~ and Zeitlinger, M.~ and Koepp, M.J.~ and Asselin, M.-C.~ and Pataraia, E.~ and Langer, O.~},
      title = {Outcome Prediction of Temporal Lobe Epilepsy Surgery from P-Glycoprotein Activity Pooled Analysis of (R)-[11C]-Verapamil PET Data from Two European Centres.},
      journal = {EJNMMI Research},
      year = {2016},
      volume = {6},
      number = {Suppl 1: Abstracts 32nd International Austrian Winter Symposium, Zell am See, Austria, 20–23 January 2016},
      pages = {A12},
      issn = {2191-219X},
      url = {https://ejnmmires.springeropen.com/articles/10.1186/s13550-016-0168-9#Sec34}
    }

2015

  • Schreiner W., Karch R., Ribarics R., Cibena M., Ilieva N.
    Relative Movements of Domains in Large Molecules of the Immune System.
    Journal of Immunology Research 2015:210675, (2015) [bib]
    
    @ARTICLE{schreiner2015rmdl210675,
      author = {Schreiner, W.~ and Karch, R.~ and Ribarics, R.~ and Cibena, M.~ and Ilieva, N.~},
      title = {Relative Movements of Domains in Large Molecules of the Immune System.},
      journal = {Journal of Immunology Research},
      year = {2015},
      volume = {2015},
      pages = {210675},
      issn = {2314-7156 2314-8861 2314-7156},
      doi = {10.1155/2015/210675},
      keywords = {Humans;Mutation;Binding Sites;Protein Binding;*Molecular Dynamics Simulation;Protein Interaction Domains and Motifs;beta 2-Microglobulin/*chemistry/immunology;CD8 Antigens/*chemistry/immunology;HLA-B27 Antigen/*chemistry/immunology;Immunological Synapses/chemistry/immunology;Least-Squares Analysis;Peptides/*chemistry/immunology;Protein Structure;Secondary;Receptors;Antigen;T-Cell;alpha-beta/*chemistry/immunology;Structural Homology;Protein}
    }
  • Ribarics R., Kenn M., Karch R., Ilieva N., Schreiner W.
    Geometry Dynamics of α-Helices in Different Class I Major Histocompatibility Complexes.
    Journal of Immunology Research 2015:173593, (2015) [bib]
    
    @ARTICLE{ribarics2015gdhd173593,
      author = {Ribarics, R.~ and Kenn, M.~ and Karch, R.~ and Ilieva, N.~ and Schreiner, W.~},
      title = {Geometry Dynamics of α-Helices in Different Class I Major Histocompatibility Complexes.},
      journal = {Journal of Immunology Research},
      year = {2015},
      volume = {2015},
      pages = {173593},
      issn = {2314-7156 2314-8861 2314-7156},
      doi = {10.1155/2015/173593},
      keywords = {Humans;Mutation;Binding Sites;Protein Binding;*Molecular Dynamics Simulation;Protein Interaction Domains and Motifs;HLA-B27 Antigen/*chemistry/immunology;Immunological Synapses/chemistry/immunology;Least-Squares Analysis;Peptides/*chemistry/immunology;Protein Structure;Secondary;Receptors;Antigen;T-Cell/*chemistry/immunology}
    }
  • Bauer M., Karch R., Zeitlinger M., Philippe C., Römermann K., Stanek J., Maier-Salamon A., Wadsak W., Jäger W., Hacker M., Müller M., Langer O.
    Approaching Complete Inhibition of P-Glycoprotein at the Human Blood-Brain Barrier: An (R)-[11C]Verapamil PET Study.
    Journal of Cerebral Blood Flow and Metabolism 35(5), 743–746, (2015) [bib]
    
    @ARTICLE{bauer2015acip743746,
      author = {Bauer, M.~ and Karch, R.~ and Zeitlinger, M.~ and Philippe, C.~ and R{\"o}mermann, K.~ and Stanek, J.~ and Maier-Salamon, A.~ and Wadsak, W.~ and J{\"a}ger, W.~ and Hacker, M.~ and M{\"u}ller, M.~ and Langer, O.~},
      title = {Approaching Complete Inhibition of P-Glycoprotein at the Human Blood-Brain Barrier: An (R)-[11C]Verapamil PET Study.},
      journal = {Journal of Cerebral Blood Flow and Metabolism},
      year = {2015},
      volume = {35},
      number = {5},
      pages = {743--746},
      issn = {1559-7016 0271-678X 0271-678X},
      doi = {10.1038/jcbfm.2015.19},
      keywords = {Humans;Male;Middle Aged;Radiography;Verapamil/*administration \& dosage;*Blood-Brain Barrier/diagnostic imaging/metabolism;*Gray Matter/diagnostic imaging/metabolism;*Pituitary Gland/diagnostic imaging/metabolism;Anti-Arrhythmia Agents/administration \& dosage;ATP Binding Cassette Transporter;Subfamily B/antagonists \& inhibitors/metabolism;Carbon Isotopes/administration \& dosage;Positron-Emission Tomography;Radiopharmaceuticals/*administration \& dosage}
    }

2014

  • Bauer M., Karch R., Zeitlinger M., Liu J., Koepp M.J., Asselin M.-C., Sisodiya S.M., Hainfellner J.A., Wadsak W., Mitterhauser M., Müller M., Pataraia E., Langer O.
    In Vivo P-Glycoprotein Function before and after Epilepsy Surgery.
    Neurology 83(15), 1326–1331, (2014) [bib]
    
    @ARTICLE{bauer2014vpfb13261331,
      author = {Bauer, M.~ and Karch, R.~ and Zeitlinger, M.~ and Liu, J.~ and Koepp, M.J.~ and Asselin, M.-C.~ and Sisodiya, S.M.~ and Hainfellner, J.A.~ and Wadsak, W.~ and Mitterhauser, M.~ and M{\"u}ller, M.~ and Pataraia, E.~ and Langer, O.~},
      title = {In Vivo P-Glycoprotein Function before and after Epilepsy Surgery.},
      journal = {Neurology},
      year = {2014},
      volume = {83},
      number = {15},
      pages = {1326--1331},
      issn = {1526-632X 0028-3878 0028-3878},
      doi = {10.1212/WNL.0000000000000858},
      keywords = {Adult;Female;Humans;Male;Middle Aged;Pilot Projects;Postoperative Period;Drug Resistance;Preoperative Period;Positron-Emission Tomography;Anticonvulsants;ATP Binding Cassette Transporter;Subfamily B;Member 1/*metabolism;Carbon Radioisotopes;Epilepsy;Temporal Lobe/diagnostic imaging/*metabolism/*surgery;Functional Neuroimaging;Hippocampus/metabolism;Temporal Lobe/diagnostic imaging/*metabolism;Verapamil}
    }
  • Ribarics R., Karch R., Ilieva N., Schreiner W.
    Geometric Analysis of Alloreactive HLA α-Helices.
    BioMed Research International 2014:943186, (2014) [bib]
    
    @ARTICLE{ribarics2014gaah943186,
      author = {Ribarics, R.~ and Karch, R.~ and Ilieva, N.~ and Schreiner, W.~},
      title = {Geometric Analysis of Alloreactive HLA α-Helices.},
      journal = {BioMed Research International},
      year = {2014},
      volume = {2014},
      pages = {943186},
      issn = {2314-6141 2314-6133},
      doi = {10.1155/2014/943186},
      keywords = {Humans;*Molecular Dynamics Simulation;Protein Structure;Secondary;HLA Antigens/*chemistry}
    }

2013

  • Bauer M., Karch R., Zeitlinger M., Stanek J., Philippe C., Wadsak W., Mitterhauser M., Jäger W., Haslacher H., Müller M., Langer O.
    Interaction of 11C-Tariquidar and 11C-Elacridar with P-Glycoprotein and Breast Cancer Resistance Protein at the Human Blood–Brain Barrier.
    Journal of Nuclear Medicine 54(8), 1181–1187, (2013) [bib]
    
    @ARTICLE{bauer2013i<11C-Tariquidar and 11C-Elacridar with P-Glycoprotein and Breast Cancer Resistance Protein at the Human Blood–Brain Barrier.},
      journal = {Journal of Nuclear Medicine},
      year = {2013},
      volume = {54},
      number = {8},
      pages = {1181--1187},
      issn = {1535-5667 0161-5505 0161-5505},
      doi = {10.2967/jnumed.112.118232},
      keywords = {Adult;Humans;Male;Protein Binding;blood-brain barrier;P-glycoprotein;breast cancer resistance protein;Positron-Emission Tomography;ATP Binding Cassette Transporter;Subfamily B;Member 1/*metabolism;Carbon Radioisotopes;11C-elacridar;11C-tariquidar;Acridines/*metabolism;ATP Binding Cassette Transporter;Subfamily G;Member 2;ATP-Binding Cassette Transporters/*metabolism;Blood-Brain Barrier/diagnostic imaging/*metabolism;Neoplasm Proteins/*metabolism;Quinolines/*metabolism;Tetrahydroisoquinolines/*metabolism}
    }
  • Müllauer J., Karch R., Bankstahl J.P., Bankstahl M., Stanek J., Wanek T., Mairinger S., Müller M., Löscher W., Langer O., Kuntner C.
    Assessment of Cerebral P-Glycoprotein Expression and Function with PET by Combined [11C]Inhibitor and [11C]Substrate Scans in Rats.
    Nuclear Medicine and Biology 40(6), 755–763, (2013) [bib]
    
    @ARTICLE{muellauer2013acpe755763,
      author = {M{\"u}llauer, J.~ and Karch, R.~ and Bankstahl, J.P.~ and Bankstahl, M.~ and Stanek, J.~ and Wanek, T.~ and Mairinger, S.~ and M{\"u}ller, M.~ and L{\"o}scher, W.~ and Langer, O.~ and Kuntner, C.~},
      title = {Assessment of Cerebral P-Glycoprotein Expression and Function with PET by Combined [11C]Inhibitor and [11C]Substrate Scans in Rats.},
      journal = {Nuclear Medicine and Biology},
      year = {2013},
      volume = {40},
      number = {6},
      pages = {755--763},
      issn = {1872-9614 0969-8051},
      doi = {10.1016/j.nucmedbio.2013.05.005},
      keywords = {Animals;Female;Rats;Kinetics;Rats;Sprague-Dawley;P-glycoprotein;*Gene Expression Regulation;Carbon Radioisotopes;(R)-[(11)C]verapamil;[(11)C]elacridar;[(11)C]tariquidar;Acridines/metabolism/pharmacology;ATP Binding Cassette Transporter;Subfamily B;Member 1/*antagonists \& inhibitors/*metabolism;Biological Transport;Blood–brain barrier;Brain/*metabolism;Positron emission tomography;Positron-Emission Tomography/*methods;Quinolines/metabolism/pharmacology;Tetrahydroisoquinolines/metabolism/pharmacology;Verapamil/metabolism}
    }
  • Bauer M., Zeitlinger M., Karch R., Philippe C., Wadsak W., Mitterhauser M., Karanikas G., Mueller M., Langer O.
    First Human Brain Imaging of C-11-Tariquidar and C-11-Elacridar to Measure the Function of P-Glycoprotein and Breast Cancer Resistance Protein.
    British Journal of Clinical Pharmacology 75(Suppl 1: Abstracts 2012 Joint Annual Meeting of the German and Austrian Societies for Clinical Pharmacology and Toxicology, Stuttgart, Germany, 19–23 October 2012), 1, (2013) [bib]
    
    @ARTICLE{bauer2013fhbi11,
      author = {Bauer, M.~ and Zeitlinger, M.~ and Karch, R.~ and Philippe, C.~ and Wadsak, W.~ and Mitterhauser, M.~ and Karanikas, G.~ and Mueller, M.~ and Langer, O.~},
      title = {First Human Brain Imaging of C-11-Tariquidar and C-11-Elacridar to Measure the Function of P-Glycoprotein and Breast Cancer Resistance Protein.},
      journal = {British Journal of Clinical Pharmacology},
      year = {2013},
      volume = {75},
      number = {Suppl 1: Abstracts 2012 Joint Annual Meeting of the German and Austrian Societies for Clinical Pharmacology and Toxicology, Stuttgart, Germany, 19–23 October 2012},
      pages = {1},
      issn = {0306-5251},
      doi = {10.1111/bcp.12067}
    }

2012

  • Sauermann R., Feurstein T., Karch R., Kjellsson M.C., Jäger W., Böhmdorfer M., Püspök A., Langenberger H., Wild T., Winkler S., Zeitlinger M.
    Abscess Penetration of Cefpirome: Concentrations and Simulated Pharmacokinetic Profiles in Pus.
    European Journal of Clinical Pharmacology 68(10), 1419–1423, (2012) [bib]
    
    @ARTICLE{sauermann2012apcc14191423,
      author = {Sauermann, R.~ and Feurstein, T.~ and Karch, R.~ and Kjellsson, M.C.~ and J{\"a}ger, W.~ and B{\"o}hmdorfer, M.~ and P{\"u}sp{\"o}k, A.~ and Langenberger, H.~ and Wild, T.~ and Winkler, S.~ and Zeitlinger, M.~},
      title = {Abscess Penetration of Cefpirome: Concentrations and Simulated Pharmacokinetic Profiles in Pus.},
      journal = {European Journal of Clinical Pharmacology},
      year = {2012},
      volume = {68},
      number = {10},
      pages = {1419--1423},
      issn = {1432-1041},
      doi = {10.1007/s00228-012-1270-1},
      url = {https://doi.org/10.1007/s00228-012-1270-1}
    }
  • Sauermann R., Karch R., Kjellsson M.C., Feurstein T., Püspök A., Langenberger H., Böhmdorfer M., Jäger W., Zeitlinger M.
    Good Penetration of Moxifloxacin into Human Abscesses.
    Pharmacology 90(3-4), 146–150, (2012) [bib]
    
    @ARTICLE{sauermann2012gpmi146150,
      author = {Sauermann, R.~ and Karch, R.~ and Kjellsson, M.C.~ and Feurstein, T.~ and P{\"u}sp{\"o}k, A.~ and Langenberger, H.~ and B{\"o}hmdorfer, M.~ and J{\"a}ger, W.~ and Zeitlinger, M.~},
      title = {Good Penetration of Moxifloxacin into Human Abscesses.},
      journal = {Pharmacology},
      year = {2012},
      volume = {90},
      number = {3-4},
      pages = {146--150},
      issn = {1423-0313 0031-7012},
      doi = {10.1159/000341550},
      keywords = {Adult;Female;Humans;Male;Middle Aged;Microbial Sensitivity Tests;Abscess/*drug therapy/metabolism;Anti-Infective Agents/*pharmacokinetics;Aza Compounds/*pharmacokinetics/pharmacology;Fluoroquinolones;Moxifloxacin;Quinolines/*pharmacokinetics/pharmacology}
    }
  • Schreiner W., Karch R., Knapp B., Ilieva N.
    Relaxation Estimation of RMSD in Molecular Dynamics Immunosimulations.
    Computational and Mathematical Methods in Medicine 2012:173521, (2012) [bib]
    
    @ARTICLE{schreiner2012rerm173521,
      author = {Schreiner, W.~ and Karch, R.~ and Knapp, B.~ and Ilieva, N.~},
      title = {Relaxation Estimation of RMSD in Molecular Dynamics Immunosimulations.},
      journal = {Computational and Mathematical Methods in Medicine},
      year = {2012},
      volume = {2012},
      pages = {173521},
      issn = {1748-6718 1748-670X 1748-670X},
      doi = {10.1155/2012/173521},
      keywords = {Algorithms;Animals;Humans;Time Factors;Reproducibility of Results;Models;Statistical;Models;Theoretical;Computer Simulation;Computational Biology/*methods;*Molecular Dynamics Simulation;Models;Molecular;Immune System/chemistry;Molecular Conformation;Proteins/chemistry;Receptors;Antigen;T-Cell/chemistry}
    }
  • Bauer M., Zeitlinger M., Karch R., Matzneller P., Stanek J., Jäger W., Böhmdorfer M., Wadsak W., Mitterhauser M., Bankstahl J.P., Löscher W., Koepp M., Kuntner C., Müller M., Langer O.
    Pgp-Mediated Interaction between (R)-[11C]Verapamil and Tariquidar at the Human Blood–Brain Barrier: A Comparison with Rat Data.
    Clinical Pharmacology and Therapeutics 91(2), 227–233, (2012) [bib]
    
    @ARTICLE{bauer2012pibr227233,
      author = {Bauer, M.~ and Zeitlinger, M.~ and Karch, R.~ and Matzneller, P.~ and Stanek, J.~ and J{\"a}ger, W.~ and B{\"o}hmdorfer, M.~ and Wadsak, W.~ and Mitterhauser, M.~ and Bankstahl, J.P.~ and L{\"o}scher, W.~ and Koepp, M.~ and Kuntner, C.~ and M{\"u}ller, M.~ and Langer, O.~},
      title = {Pgp-Mediated Interaction between (R)-[11C]Verapamil and Tariquidar at the Human Blood–Brain Barrier: A Comparison with Rat Data.},
      journal = {Clinical Pharmacology and Therapeutics},
      year = {2012},
      volume = {91},
      number = {2},
      pages = {227--233},
      issn = {1532-6535 0009-9236 0009-9236},
      doi = {10.1038/clpt.2011.217},
      keywords = {Animals;Humans;Dose-Response Relationship;Drug;Rats;Species Specificity;Carbon Radioisotopes;ATP Binding Cassette Transporter;Subfamily B;Member 1/*antagonists \& inhibitors;Blood-Brain Barrier/diagnostic imaging/*drug effects;Brain/diagnostic imaging/*metabolism;Calcium Channel Blockers/pharmacology;Positron-Emission Tomography/methods/statistics \& numerical data;Quinolines/blood/*pharmacology;Verapamil/*pharmacokinetics}
    }

2011

  • Bauer M., Zeitlinger M., Karch R., Matzneller P., Mueller M., Langer O.
    P-Glycoprotein Mediated Drug-Drug Interaction at the Human Blood-Brain Barrier Studied with Positron Emission Tomography, a Comparison with Rat Data.
    British Journal of Clinical Pharmacology 72(Suppl 1: Abstracts 2011 Joint Annual Meeting of the German, Swiss, and Austrian Societies for Clinical Pharmacology and Toxicology), 25, (2011) [bib]
    
    @ARTICLE{bauer2011pmdi2525,
      author = {Bauer, M.~ and Zeitlinger, M.~ and Karch, R.~ and Matzneller, P.~ and Mueller, M.~ and Langer, O.~},
      title = {P-Glycoprotein Mediated Drug-Drug Interaction at the Human Blood-Brain Barrier Studied with Positron Emission Tomography, a Comparison with Rat Data.},
      journal = {British Journal of Clinical Pharmacology},
      year = {2011},
      volume = {72},
      number = {Suppl 1: Abstracts 2011 Joint Annual Meeting of the German, Swiss, and Austrian Societies for Clinical Pharmacology and Toxicology},
      pages = {25},
      issn = {0306-5251},
      doi = {10.1111/j.1365-2125.2011.04074.x}
    }
  • Wagner C.C., Simpson M., Zeitlinger M., Bauer M., Karch R., Abrahim A., Feurstein T., Schütz M., Kletter K., Müller M., Lappin G., Langer O.
    A Combined Accelerator Mass Spectrometry-Positron Emission Tomography Human Microdose Study with 14C- and 11C-Labelled Verapamil.
    Clinical Pharmacokinetics 50(2), 111–120, (2011) [bib]
    
    @ARTICLE{wagner2011acam111120,
      author = {Wagner, C.C.~ and Simpson, M.~ and Zeitlinger, M.~ and Bauer, M.~ and Karch, R.~ and Abrahim, A.~ and Feurstein, T.~ and Sch{\"u}tz, M.~ and Kletter, K.~ and M{\"u}ller, M.~ and Lappin, G.~ and Langer, O.~},
      title = {A Combined Accelerator Mass Spectrometry-Positron Emission Tomography Human Microdose Study with 14C- and 11C-Labelled Verapamil.},
      journal = {Clinical Pharmacokinetics},
      year = {2011},
      volume = {50},
      number = {2},
      pages = {111--120},
      issn = {1179-1926 0312-5963 0312-5963},
      doi = {10.2165/11537250-000000000-00000},
      keywords = {Humans;Male;Area Under Curve;Cross-Over Studies;Models;Biological;Half-Life;Positron-Emission Tomography;Carbon Radioisotopes;Blood-Brain Barrier;Calcium Channel Blockers/*administration \& dosage/blood/*pharmacokinetics;Tandem Mass Spectrometry;Verapamil/*administration \& dosage/blood/*pharmacokinetics}
    }

2010

  • Kuntner C., Bankstahl J.P., Bankstahl M., Stanek J., Wanek T., Stundner G., Karch R., Brauner R., Meier M., Ding X., Müller M., Löscher W., Langer O.
    Dose-Response Assessment of Tariquidar and Elacridar and Regional Quantification of P-Glycoprotein Inhibition at the Rat Blood-Brain Barrier Using (R)-[11C]Verapamil PET.
    European Journal of Nuclear Medicine and Molecular Imaging 37(5), 942–953, (2010) [bib]
    
    @ARTICLE{kuntner2010date942953,
      author = {Kuntner, C.~ and Bankstahl, J.P.~ and Bankstahl, M.~ and Stanek, J.~ and Wanek, T.~ and Stundner, G.~ and Karch, R.~ and Brauner, R.~ and Meier, M.~ and Ding, X.~ and M{\"u}ller, M.~ and L{\"o}scher, W.~ and Langer, O.~},
      title = {Dose-Response Assessment of Tariquidar and Elacridar and Regional Quantification of P-Glycoprotein Inhibition at the Rat Blood-Brain Barrier Using (R)-[11C]Verapamil PET.},
      journal = {European Journal of Nuclear Medicine and Molecular Imaging},
      year = {2010},
      volume = {37},
      number = {5},
      pages = {942--953},
      issn = {1619-7089 1619-7070 1619-7070},
      doi = {10.1007/s00259-009-1332-5},
      keywords = {Animals;Female;Dose-Response Relationship;Drug;Rats;Rats;Sprague-Dawley;Blood Proteins/metabolism;Biological Transport/drug effects;Carbon Radioisotopes;*Positron-Emission Tomography;*Verapamil/chemistry/metabolism;Acridines/administration \& dosage/*pharmacology;ATP Binding Cassette Transporter;Subfamily B;Member 1/*antagonists \& inhibitors/metabolism;Blood-Brain Barrier/*diagnostic imaging/*drug effects/metabolism;Gene Expression Regulation/drug effects;Quinolines/administration \& dosage/*pharmacology;Stereoisomerism;Tetrahydroisoquinolines/administration \& dosage/*pharmacology}
    }
  • Bauer M., Karch R., Neumann F., Wagner C.C., Kletter K., Müller M., Löscher W., Zeitlinger M., Langer O.
    Assessment of Regional Differences in Tariquidar-Induced P-Glycoprotein Modulation at the Human Blood–Brain Barrier.
    Journal of Cerebral Blood Flow and Metabolism 30(3), 510–515, (2010) [bib]
    
    @ARTICLE{bauer2010ardt510515,
      author = {Bauer, M.~ and Karch, R.~ and Neumann, F.~ and Wagner, C.C.~ and Kletter, K.~ and M{\"u}ller, M.~ and L{\"o}scher, W.~ and Zeitlinger, M.~ and Langer, O.~},
      title = {Assessment of Regional Differences in Tariquidar-Induced P-Glycoprotein Modulation at the Human Blood–Brain Barrier.},
      journal = {Journal of Cerebral Blood Flow and Metabolism},
      year = {2010},
      volume = {30},
      number = {3},
      pages = {510--515},
      issn = {1559-7016 0271-678X 0271-678X},
      doi = {10.1038/jcbfm.2009.265},
      keywords = {Adult;Humans;Male;Infusions;Intravenous;Image Processing;Computer-Assisted;Positron-Emission Tomography;Verapamil/metabolism;ATP Binding Cassette Transporter;Subfamily B;Member 1/*physiology;Blood-Brain Barrier/*drug effects/*physiology;Brain/diagnostic imaging;Calcium Channel Blockers/metabolism;Drug Resistance;Multiple/drug effects;Epilepsy/chemically induced/physiopathology;Quinolines/*pharmacology}
    }
  • Karch R., Neumann F., Ullrich R., Heinze G., Neumüller J., Podesser B.K., Neumann M.
    Methods from the Theory of Random Heterogeneous Media for Quantifying Myocardial Morphology in Normal and Dilated Hearts.
    Annals of Biomedical Engineering 38(2), 308–318, (2010) [bib]
    
    @ARTICLE{karch2010mtrh308318,
      author = {Karch, R.~ and Neumann, F.~ and Ullrich, R.~ and Heinze, G.~ and Neum{\"u}ller, J.~ and Podesser, B.K.~ and Neumann, M.~},
      title = {Methods from the Theory of Random Heterogeneous Media for Quantifying Myocardial Morphology in Normal and Dilated Hearts.},
      journal = {Annals of Biomedical Engineering},
      year = {2010},
      volume = {38},
      number = {2},
      pages = {308--318},
      issn = {1573-9686 0090-6964},
      doi = {10.1007/s10439-009-9848-1},
      keywords = {Adult;Female;Humans;Male;Middle Aged;Models;Statistical;Data Interpretation;Statistical;Computer Simulation;Myocardium/*pathology;Image Interpretation;Computer-Assisted/methods;*Models;Anatomic;*Models;Cardiovascular;Cardiomyopathies/*pathology;Myocytes;Cardiac/*pathology}
    }

2009

  • Wagner C.C., Bauer M., Karch R., Feurstein T., Kopp S., Chiba P., Kletter K., Löscher W., Müller M., Zeitlinger M., Langer O.
    A Pilot Study to Assess the Efficacy of Tariquidar to Inhibit P-Glycoprotein at the Human Blood–Brain Barrier with (R)-11C-Verapamil and PET.
    Journal of Nuclear Medicine 50(12), 1954–1961, (2009) [bib]
    
    @ARTICLE{wagner2009apst19541961,
      author = {Wagner, C.C.~ and Bauer, M.~ and Karch, R.~ and Feurstein, T.~ and Kopp, S.~ and Chiba, P.~ and Kletter, K.~ and L{\"o}scher, W.~ and M{\"u}ller, M.~ and Zeitlinger, M.~ and Langer, O.~},
      title = {A Pilot Study to Assess the Efficacy of Tariquidar to Inhibit P-Glycoprotein at the Human Blood–Brain Barrier with (R)-11C-Verapamil and PET.},
      journal = {Journal of Nuclear Medicine},
      year = {2009},
      volume = {50},
      number = {12},
      pages = {1954--1961},
      issn = {1535-5667 0161-5505 0161-5505},
      doi = {10.2967/jnumed.109.063289},
      keywords = {Adult;Humans;Male;Pilot Projects;Kinetics;Positron-Emission Tomography;ATP Binding Cassette Transporter;Subfamily B;Member 1/*antagonists \& inhibitors/metabolism;Quinolines/*pharmacology;Blood-Brain Barrier/*diagnostic imaging/drug effects/*metabolism;Carbon Radioisotopes/chemistry;Verapamil/chemistry/*metabolism}
    }
  • Bauer M., Wagner C., Karch R., Feurstein T., Kletter K., Zeitlinger M., Mueller M., Langer O.
    Regional Differences in P-Glycoprotein Function at the Human Blood-Brain Barrier.
    Journal of Cerebral Blood Flow and Metabolism 29(Suppl 1: Abstracts 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET, Chicago, IL, USA, 29 June–3 July 2009), S14–S15, (2009) [bib]
    
    @ARTICLE{bauer2009rdpfs14s15,
      author = {Bauer, M.~ and Wagner, C.~ and Karch, R.~ and Feurstein, T.~ and Kletter, K.~ and Zeitlinger, M.~ and Mueller, M.~ and Langer, O.~},
      title = {Regional Differences in P-Glycoprotein Function at the Human Blood-Brain Barrier.},
      journal = {Journal of Cerebral Blood Flow and Metabolism},
      year = {2009},
      volume = {29},
      number = {Suppl 1: Abstracts 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET, Chicago, IL, USA, 29 June–3 July 2009},
      pages = {S14--S15},
      issn = {0271-678X},
      doi = {10.1038%2Fjcbfm.2009.115}
    }
  • Bauer M., Karch R., Neumann F., Abrahim A., Wagner C.C., Kletter K., Müller M., Zeitlinger M., Langer O.
    Age Dependency of Cerebral P-Gp Function Measured with (R)-[11C]Verapamil and PET.
    European Journal of Clinical Pharmacology 65(9), 941–946, (2009) [bib]
    
    @ARTICLE{bauer2009adcp941946,
      author = {Bauer, M.~ and Karch, R.~ and Neumann, F.~ and Abrahim, A.~ and Wagner, C.C.~ and Kletter, K.~ and M{\"u}ller, M.~ and Zeitlinger, M.~ and Langer, O.~},
      title = {Age Dependency of Cerebral P-Gp Function Measured with (R)-[11C]Verapamil and PET.},
      journal = {European Journal of Clinical Pharmacology},
      year = {2009},
      volume = {65},
      number = {9},
      pages = {941--946},
      issn = {1432-1041 0031-6970 0031-6970},
      doi = {10.1007/s00228-009-0709-5},
      keywords = {Adult;Female;Humans;Male;Aged;Middle Aged;Age Factors;*Aging;Vasodilator Agents;ATP Binding Cassette Transporter;Subfamily B;Member 1/*metabolism;*Positron-Emission Tomography;*Carbon Radioisotopes;*Verapamil;Amygdala/diagnostic imaging/metabolism;Blood-Brain Barrier/metabolism;Brain/*diagnostic imaging/*metabolism;Cerebellum/diagnostic imaging/metabolism;Cerebral Cortex/diagnostic imaging/metabolism;Frontal Lobe/diagnostic imaging/metabolism}
    }
  • Bauer M., Wagner C., Karch R., Kletter K., Mueller M., Zeitlinger M., Langer O.
    A Pilot Study to Assess the Efficacy of Tariquidar to Inhibit Cerebral P-Glycoprotein in Humans with (R)-[C-11]Verapamil and PET.
    Basic & Clinical Pharmacology & Toxicology 105(Suppl 1: Abstracts 9th Congress of the European Association for Clinical Pharmacology and Therapeutics, Edinburgh, UK, 12–15 July 2009), 23, (2009) [bib]
    
    @ARTICLE{bauer2009apst2323,
      author = {Bauer, M.~ and Wagner, C.~ and Karch, R.~ and Kletter, K.~ and Mueller, M.~ and Zeitlinger, M.~ and Langer, O.~},
      title = {A Pilot Study to Assess the Efficacy of Tariquidar to Inhibit Cerebral P-Glycoprotein in Humans with (R)-[C-11]Verapamil and PET.},
      journal = {Basic \& Clinical Pharmacology \& Toxicology},
      year = {2009},
      volume = {105},
      number = {Suppl 1: Abstracts 9th Congress of the European Association for Clinical Pharmacology and Therapeutics, Edinburgh, UK, 12–15 July 2009},
      pages = {23},
      issn = {1742-7835},
      doi = {https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1742-7843.2009.00436.x},
      url = {https://onlinelibrary.wiley.com/toc/17427843/2009/105/s1}
    }
  • Wagner C., Bauer M., Simpson M., Lappin G., Karch R., Feurstein T., Kletter K., Mueller M., Zeitlinger M., Langer O.
    Combined Accelerator Mass Spectrometry and Positron Emission Tomography Microdosing to Assess Plasma and Brain Tissue Pharmacokinetics of Verapamil in Humans.
    Basic & Clinical Pharmacology & Toxicology 105(Suppl 1: Abstracts 9th Congress of the European Association for Clinical Pharmacology and Therapeutics, Edinburgh, UK, 12–15 July 2009), 31, (2009) [bib]
    
    @ARTICLE{wagner2009cams3131,
      author = {Wagner, C.~ and Bauer, M.~ and Simpson, M.~ and Lappin, G.~ and Karch, R.~ and Feurstein, T.~ and Kletter, K.~ and Mueller, M.~ and Zeitlinger, M.~ and Langer, O.~},
      title = {Combined Accelerator Mass Spectrometry and Positron Emission Tomography Microdosing to Assess Plasma and Brain Tissue Pharmacokinetics of Verapamil in Humans.},
      journal = {Basic \& Clinical Pharmacology \& Toxicology},
      year = {2009},
      volume = {105},
      number = {Suppl 1: Abstracts 9th Congress of the European Association for Clinical Pharmacology and Therapeutics, Edinburgh, UK, 12–15 July 2009},
      pages = {31},
      issn = {1742-7835},
      doi = {10.1111/j.1742-7843.2009.00436.x}
    }
  • Sauermann R., Feurstein T., Karch R., Puespoek A., Langenberger H., Jaeger W., Miksits M., Zeitlinger M.
    Abscess Penetration of Cefpirome in Humans.
    Basic & Clinical Pharmacology & Toxicology 105(Suppl 1: Abstracts 9th Congress of the European Association for Clinical Pharmacology and Therapeutics, Edinburgh, UK, 12–15 July 2009), 36, (2009) [bib]
    
    @ARTICLE{sauermann2009apch3636,
      author = {Sauermann, R.~ and Feurstein, T.~ and Karch, R.~ and Puespoek, A.~ and Langenberger, H.~ and Jaeger, W.~ and Miksits, M.~ and Zeitlinger, M.~},
      title = {Abscess Penetration of Cefpirome in Humans.},
      journal = {Basic \& Clinical Pharmacology \& Toxicology},
      year = {2009},
      volume = {105},
      number = {Suppl 1: Abstracts 9th Congress of the European Association for Clinical Pharmacology and Therapeutics, Edinburgh, UK, 12–15 July 2009},
      pages = {36},
      issn = {1742-7835},
      doi = {10.1111/j.1742-7843.2009.00436.x}
    }
  • Kuntner C., Kesner A.L., Bauer M., Kremslehner R., Wanek T., Mandler M., Karch R., Stanek J., Wolf T., Müller M., Langer O.
    Limitations of Small Animal PET Imaging with [18F]FDDNP and FDG for Quantitative Studies in a Transgenic Mouse Model of Alzheimer’s Disease.
    Molecular Imaging and Biology 11(4), 236–240, (2009) [bib]
    
    @ARTICLE{kuntner2009lsap236240,
      author = {Kuntner, C.~ and Kesner, A.L.~ and Bauer, M.~ and Kremslehner, R.~ and Wanek, T.~ and Mandler, M.~ and Karch, R.~ and Stanek, J.~ and Wolf, T.~ and M{\"u}ller, M.~ and Langer, O.~},
      title = {Limitations of Small Animal PET Imaging with [18F]FDDNP and FDG for Quantitative Studies in a Transgenic Mouse Model of Alzheimer’s Disease.},
      journal = {Molecular Imaging and Biology},
      year = {2009},
      volume = {11},
      number = {4},
      pages = {236--240},
      issn = {1860-2002 1536-1632},
      doi = {10.1007/s11307-009-0198-z},
      keywords = {Animals;Statistics;Nonparametric;Mice;Phantoms;Imaging;Imaging;Three-Dimensional/methods;Positron-Emission Tomography/*methods;*Disease Models;Animal;Alzheimer Disease/*diagnostic imaging/pathology;Amyloid beta-Peptides/metabolism;Brain Chemistry;Brain/*diagnostic imaging/pathology;Fluorodeoxyglucose F18/*pharmacokinetics;Mice;Transgenic;Nitriles/*pharmacokinetics;Radiopharmaceuticals/*pharmacokinetics}
    }
  • Bauer M., Karch R., Neumann F., Abrahim A., Kletter K., Mueller M., Langer O.
    Decreased Blood-Brain Barrier P-Glycoprotein Function with Aging.
    Journal of Nuclear Medicine 50(Suppl 2):Abstract 606, (2009) [bib]
    
    @ARTICLE{bauer2009dbbpabstract 606,
      author = {Bauer, M.~ and Karch, R.~ and Neumann, F.~ and Abrahim, A.~ and Kletter, K.~ and Mueller, M.~ and Langer, O.~},
      title = {Decreased Blood-Brain Barrier P-Glycoprotein Function with Aging.},
      journal = {Journal of Nuclear Medicine},
      year = {2009},
      volume = {50},
      number = {Suppl 2},
      pages = {Abstract 606},
      issn = {0161-5505},
      url = {http://jnm.snmjournals.org/content/50/supplement_2/606.abstract?sid=bff8ccfb-2b3a-4435-a3d1-7429b1791ed6}
    }
  • Bankstahl J., Kuntner C., Abrahim A., Karch R., Langer O., Loescher W.
    Tariquidar-Induced P-Glycoprotein Inhibition at the Rat Blood-Brain Barrier Studied by Positron Emission Tomography with (R)-[11C]Verapamil.
    Epilepsia 50(Suppl 4: Abstracts 8th European Congress on Epileptology, Berlin, Germany, 21–25 September 2008), 119, (2009) [bib]
    
    @ARTICLE{bankstahl2009tpia119119,
      author = {Bankstahl, J.~ and Kuntner, C.~ and Abrahim, A.~ and Karch, R.~ and Langer, O.~ and Loescher, W.~},
      title = {Tariquidar-Induced P-Glycoprotein Inhibition at the Rat Blood-Brain Barrier Studied by Positron Emission Tomography with (R)-[11C]Verapamil.},
      journal = {Epilepsia},
      year = {2009},
      volume = {50},
      number = {Suppl 4: Abstracts 8th European Congress on Epileptology, Berlin, Germany, 21–25 September 2008},
      pages = {119},
      issn = {0013-9580},
      url = {https://onlinelibrary.wiley.com/toc/15281167/2009/50/s4}
    }

2008

  • Bankstahl J.P., Kuntner C., Abrahim A., Karch R., Stanek J., Wanek T., Wadsak W., Kletter K., Müller M., Löscher W., Langer O.
    Tariquidar-Induced P-Glycoprotein Inhibition at the Rat Blood–Brain Barrier Studied with (R)-11C-Verapamil and PET.
    Journal of Nuclear Medicine 49(8), 1328–1335, (2008) [bib]
    
    @ARTICLE{bankstahl2008tpia13281335,
      author = {Bankstahl, J.P.~ and Kuntner, C.~ and Abrahim, A.~ and Karch, R.~ and Stanek, J.~ and Wanek, T.~ and Wadsak, W.~ and Kletter, K.~ and M{\"u}ller, M.~ and L{\"o}scher, W.~ and Langer, O.~},
      title = {Tariquidar-Induced P-Glycoprotein Inhibition at the Rat Blood–Brain Barrier Studied with (R)-11C-Verapamil and PET.},
      journal = {Journal of Nuclear Medicine},
      year = {2008},
      volume = {49},
      number = {8},
      pages = {1328--1335},
      issn = {0161-5505 1535-5667 0161-5505},
      doi = {10.2967/jnumed.108.051235},
      keywords = {Animals;Female;Models;Biological;Rats;Rats;Wistar;Tissue Distribution;Carbon Radioisotopes;Biological Transport;Stereoisomerism;Quinolines/*pharmacology;ATP Binding Cassette Transporter;Subfamily B;Member 1/antagonists \& inhibitors/*metabolism;Blood-Brain Barrier/*metabolism;Calcium Channel Blockers/chemistry/*pharmacokinetics;Positron-Emission Tomography/methods;Verapamil/chemistry/*pharmacokinetics}
    }
  • Abrahim A., Luurtsema G., Bauer M., Karch R., Lubberink M., Pataraia E., Joukhadar C., Kletter K., Lammertsma A.A., Baumgartner C., Müller M., Langer O.
    Peripheral Metabolism of (R)-[11C]Verapamil in Epilepsy Patients.
    European Journal of Nuclear Medicine and Molecular Imaging 35(1), 116–123, (2008) [bib]
    
    @ARTICLE{abrahim2008pmre116123,
      author = {Abrahim, A.~ and Luurtsema, G.~ and Bauer, M.~ and Karch, R.~ and Lubberink, M.~ and Pataraia, E.~ and Joukhadar, C.~ and Kletter, K.~ and Lammertsma, A.A.~ and Baumgartner, C.~ and M{\"u}ller, M.~ and Langer, O.~},
      title = {Peripheral Metabolism of (R)-[11C]Verapamil in Epilepsy Patients.},
      journal = {European Journal of Nuclear Medicine and Molecular Imaging},
      year = {2008},
      volume = {35},
      number = {1},
      pages = {116--123},
      issn = {1619-7089 1619-7070},
      doi = {10.1007/s00259-007-0556-5},
      keywords = {Adult;Female;Humans;Male;Middle Aged;Case-Control Studies;Injections;Chromatography;High Pressure Liquid;Carbon Radioisotopes;Stereoisomerism;Calcium Channel Blockers/administration \& dosage/blood/*chemistry/*metabolism;Epilepsy/blood/*metabolism;Solid Phase Extraction;Verapamil/administration \& dosage/blood/*chemistry/*metabolism}
    }

2007

  • Bauer M., Langer O., Hammers A., Karch R., Pataraia E., Koepp M.J., Abrahim A., Luurtsema G., Kletter K., Baumgartner C., Muller M.
    Regionally Increased Temporal Lobe Efflux of R-[11]Verapamil Occurs in Some Patients with Therapy Refractory Epilepsy.
    Journal of Cerebral Blood Flow and Metabolism 27(Suppl 1, Abstracts 23rd International Symposium on Cerebral Blood Flow, Metabolism and Function, 20–24 May 2007, Osaka, Japan), BP14–03U, (2007) [bib]
    
    @ARTICLE{bauer2007ritlbp1403u,
      author = {Bauer, M.~ and Langer, O.~ and Hammers, A.~ and Karch, R.~ and Pataraia, E.~ and Koepp, M.J.~ and Abrahim, A.~ and Luurtsema, G.~ and Kletter, K.~ and Baumgartner, C.~ and Muller, M.~},
      title = {Regionally Increased Temporal Lobe Efflux of R-[11]Verapamil Occurs in Some Patients with Therapy Refractory Epilepsy.},
      journal = {Journal of Cerebral Blood Flow and Metabolism},
      year = {2007},
      volume = {27},
      number = {Suppl 1, Abstracts 23rd International Symposium on Cerebral Blood Flow, Metabolism and Function, 20–24 May 2007, Osaka, Japan},
      pages = {BP14--03U},
      doi = {10.1038/jcbfm.2007.100},
      url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-36348939784\&partnerID=40\&md5=e918a2378393fa0054e6c312e0cf4607}
    }
  • Langer O., Bauer M., Hammers A., Karch R., Pataraia E., Koepp M.J., Abrahim A., Luurtsema G., Brunner M., Sunder-Plassmann R., Zimprich F., Joukhadar C., Gentzsch S., Dudczak R., Kletter K., Müller M., Baumgartner C.
    Pharmacoresistance in Epilepsy: A Pilot Pet Study with the P-Glycoprotein Substrate.
    Epilepsia 48(9), 1774–1784, (2007) [bib]
    
    @ARTICLE{langer2007peap17741784,
      author = {Langer, O.~ and Bauer, M.~ and Hammers, A.~ and Karch, R.~ and Pataraia, E.~ and Koepp, M.J.~ and Abrahim, A.~ and Luurtsema, G.~ and Brunner, M.~ and Sunder-Plassmann, R.~ and Zimprich, F.~ and Joukhadar, C.~ and Gentzsch, S.~ and Dudczak, R.~ and Kletter, K.~ and M{\"u}ller, M.~ and Baumgartner, C.~},
      title = {Pharmacoresistance in Epilepsy: A Pilot Pet Study with the P-Glycoprotein Substrate.},
      journal = {Epilepsia},
      year = {2007},
      volume = {48},
      number = {9},
      pages = {1774--1784},
      issn = {0013-9580 0013-9580},
      doi = {10.1111/j.1528-1167.2007.01116.x},
      keywords = {Adult;Female;Humans;Male;Middle Aged;Pilot Projects;Models;Biological;Age of Onset;Tissue Distribution;Drug Resistance;ATP Binding Cassette Transporter;Subfamily B;Member 1/*metabolism;*Carbon Radioisotopes;*Verapamil;Brain/*diagnostic imaging/metabolism;Epilepsies;Partial/*diagnostic imaging/*drug therapy/metabolism;Functional Laterality/physiology;Hippocampus/diagnostic imaging/metabolism;Positron-Emission Tomography/*statistics \& numerical data;Radiopharmaceuticals;Temporal Lobe/diagnostic imaging/metabolism}
    }

2006

  • Karch R., Neumann M., Neumann F., Ullrich R., Neumüller J., Schreiner W.
    A Gibbs Point Field Model for the Spatial Pattern of Coronary Capillaries.
    Physica A: Statistical Mechanics and Its Applications 369(2), 599–611, (2006) [bib]
    
    @ARTICLE{karch2006agpf599611,
      author = {Karch, R.~ and Neumann, M.~ and Neumann, F.~ and Ullrich, R.~ and Neum{\"u}ller, J.~ and Schreiner, W.~},
      title = {A Gibbs Point Field Model for the Spatial Pattern of Coronary Capillaries.},
      journal = {Physica A: Statistical Mechanics and Its Applications},
      year = {2006},
      volume = {369},
      number = {2},
      pages = {599--611},
      doi = {10.1016/j.physa.2006.02.018},
      url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-33745684691\&doi=10.1016%2fj.physa.2006.02.018\&partnerID=40\&md5=19f138af2cd4898b0e087e4e80702df6}
    }
  • Bauer M., Langer O., Dal-Bianco P., Karch R., Brunner M., Abrahim A., Lanzenberger R., Hofmann A., Joukhadar C., Carminati P., Ghirardi O., Piovesan P., Forloni G., Corrado M.E., Lods N., Dudczak R., Auff E., Kletter K., Müller M.
    A Positron Emission Tomography Microdosing Study with a Potential Antiamyloid Drug in Healthy Volunteers and Patients with Alzheimer’s Disease.
    Clinical Pharmacology and Therapeutics 80(3), 216–227, (2006) [bib]
    
    @ARTICLE{bauer2006apet216227,
      author = {Bauer, M.~ and Langer, O.~ and Dal-Bianco, P.~ and Karch, R.~ and Brunner, M.~ and Abrahim, A.~ and Lanzenberger, R.~ and Hofmann, A.~ and Joukhadar, C.~ and Carminati, P.~ and Ghirardi, O.~ and Piovesan, P.~ and Forloni, G.~ and Corrado, M.E.~ and Lods, N.~ and Dudczak, R.~ and Auff, E.~ and Kletter, K.~ and M{\"u}ller, M.~},
      title = {A Positron Emission Tomography Microdosing Study with a Potential Antiamyloid Drug in Healthy Volunteers and Patients with Alzheimer’s Disease.},
      journal = {Clinical Pharmacology and Therapeutics},
      year = {2006},
      volume = {80},
      number = {3},
      pages = {216--227},
      issn = {0009-9236 0009-9236},
      doi = {10.1016/j.clpt.2006.05.007},
      keywords = {Adult;Female;Humans;Male;Time Factors;Aged;Area Under Curve;Dose-Response Relationship;Drug;Pilot Projects;Injections;Intravenous;Chromatography;High Pressure Liquid;Tissue Distribution;Carbon Radioisotopes;Positron-Emission Tomography/*methods;Blood-Brain Barrier/metabolism;Alzheimer Disease/*drug therapy/metabolism;Amyloid/*antagonists \& inhibitors/metabolism;Biological Availability;Molecular Structure;Naphthols/blood/*pharmacokinetics/therapeutic use;Neuroprotective Agents/blood/pharmacokinetics/therapeutic use}
    }
  • Schreiner W., Karch R., Neumann M., Neumann F., Szawlowski P., Roedler S.
    Optimized Arterial Trees Supplying Hollow Organs.
    Medical Engineering & Physics 28(5), 416–429, (2006) [bib]
    
    @ARTICLE{schreiner2006oats416429,
      author = {Schreiner, W.~ and Karch, R.~ and Neumann, M.~ and Neumann, F.~ and Szawlowski, P.~ and Roedler, S.~},
      title = {Optimized Arterial Trees Supplying Hollow Organs.},
      journal = {Medical Engineering \& Physics},
      year = {2006},
      volume = {28},
      number = {5},
      pages = {416--429},
      issn = {1350-4533 1350-4533},
      doi = {10.1016/j.medengphy.2005.07.019},
      keywords = {Humans;*Algorithms;Computer Simulation;Blood Flow Velocity;Blood Pressure;*Models;Cardiovascular;*Ventricular Function;Arteries/*physiology;Coronary Circulation/*physiology;Viscera/*blood supply/*physiology}
    }

2005

  • Sauermann R., Karch R., Langenberger H., Kettenbach J., Mayer-Helm B., Petsch M., Wagner C., Sautner T., Gattringer R., Karanikas G., Joukhadar C.
    Antibiotic Abscess Penetration: Fosfomycin Levels Measured in Pus and Simulated Concentration-Time Profiles.
    Antimicrobial Agents and Chemotherapy 49(11), 4448–4454, (2005) [bib]
    
    @ARTICLE{sauermann2005aapf44484454,
      author = {Sauermann, R.~ and Karch, R.~ and Langenberger, H.~ and Kettenbach, J.~ and Mayer-Helm, B.~ and Petsch, M.~ and Wagner, C.~ and Sautner, T.~ and Gattringer, R.~ and Karanikas, G.~ and Joukhadar, C.~},
      title = {Antibiotic Abscess Penetration: Fosfomycin Levels Measured in Pus and Simulated Concentration-Time Profiles.},
      journal = {Antimicrobial Agents and Chemotherapy},
      year = {2005},
      volume = {49},
      number = {11},
      pages = {4448--4454},
      issn = {0066-4804 1098-6596 0066-4804},
      doi = {10.1128/AAC.49.11.4448-4454.2005},
      keywords = {Adult;Female;Humans;Male;Aged;Middle Aged;Aged;80 and over;Abscess/*metabolism;Anti-Bacterial Agents/*pharmacokinetics;Fosfomycin/administration \& dosage/*pharmacokinetics;Permeability}
    }
  • Nadler B.A., Karch R., Neumann M., Neumann F., Aharinejad S., Schreiner W.
    Error Estimation of Geometrical Data Obtained by Histomorphometry of Oblique Vessel Sections: A Computer Model Study.
    Computers in Biology and Medicine 35(9), 829–844, (2005) [bib]
    
    @ARTICLE{nadler2005eegd829844,
      author = {Nadler, B.A.~ and Karch, R.~ and Neumann, M.~ and Neumann, F.~ and Aharinejad, S.~ and Schreiner, W.~},
      title = {Error Estimation of Geometrical Data Obtained by Histomorphometry of Oblique Vessel Sections: A Computer Model Study.},
      journal = {Computers in Biology and Medicine},
      year = {2005},
      volume = {35},
      number = {9},
      pages = {829--844},
      issn = {0010-4825 0010-4825},
      doi = {10.1016/j.compbiomed.2004.07.003},
      keywords = {Animals;Swine;*Computer Simulation;Blood Vessels/*anatomy \& histology}
    }
  • Langer O., Karch R., Müller U., Dobrozemsky G., Abrahim A., Zeitlinger M., Lackner E., Joukhadar C., Dudczak R., Kletter K., Müller M., Brunner M.
    Combined PET and Microdialysis for in Vivo Assessment of Intracellular Drug Pharmacokinetics in Humans.
    Journal of Nuclear Medicine 46(11), 1835–1841, (2005) [bib]
    
    @ARTICLE{langer2005cpmv18351841,
      author = {Langer, O.~ and Karch, R.~ and M{\"u}ller, U.~ and Dobrozemsky, G.~ and Abrahim, A.~ and Zeitlinger, M.~ and Lackner, E.~ and Joukhadar, C.~ and Dudczak, R.~ and Kletter, K.~ and M{\"u}ller, M.~ and Brunner, M.~},
      title = {Combined PET and Microdialysis for in Vivo Assessment of Intracellular Drug Pharmacokinetics in Humans.},
      journal = {Journal of Nuclear Medicine},
      year = {2005},
      volume = {46},
      number = {11},
      pages = {1835--1841},
      issn = {0161-5505 0161-5505},
      url = {http://jnm.snmjournals.org/content/46/11/1835.long},
      keywords = {Adult;Humans;Male;*Algorithms;*Models;Biological;Computer Simulation;Kinetics;Organ Specificity;Tissue Distribution;Positron-Emission Tomography/*methods;Ciprofloxacin/*pharmacokinetics/therapeutic use;Fluorine Radioisotopes/pharmacokinetics/therapeutic use;Image Interpretation;Computer-Assisted/*methods;Intracellular Fluid/metabolism;Metabolic Clearance Rate;Microdialysis/*methods;Muscle;Skeletal/diagnostic imaging/*metabolism}
    }
  • Brunner M., Langer O., Sunder-Plassmann R., Dobrozemsky G., Müller U., Wadsak W., Krcal A., Karch R., Mannhalter C., Dudczak R., Kletter K., Steiner I., Baumgartner C., Müller M.
    Influence of Functional Haplotypes in the Drug Transporter Gene ABCB1 on Central Nervous System Drug Distribution in Humans.
    Clinical Pharmacology and Therapeutics 78(2), 182–190, (2005) [bib]
    
    @ARTICLE{brunner2005ifhd182190,
      author = {Brunner, M.~ and Langer, O.~ and Sunder-Plassmann, R.~ and Dobrozemsky, G.~ and M{\"u}ller, U.~ and Wadsak, W.~ and Krcal, A.~ and Karch, R.~ and Mannhalter, C.~ and Dudczak, R.~ and Kletter, K.~ and Steiner, I.~ and Baumgartner, C.~ and M{\"u}ller, M.~},
      title = {Influence of Functional Haplotypes in the Drug Transporter Gene ABCB1 on Central Nervous System Drug Distribution in Humans.},
      journal = {Clinical Pharmacology and Therapeutics},
      year = {2005},
      volume = {78},
      number = {2},
      pages = {182--190},
      issn = {0009-9236 0009-9236},
      doi = {10.1016/j.clpt.2005.04.011},
      keywords = {Adult;Humans;Male;Area Under Curve;Case-Control Studies;Double-Blind Method;Haplotypes;Injections;Intravenous;Tissue Distribution;Positron-Emission Tomography;*Genes;MDR;Carbon Radioisotopes/administration \& dosage/pharmacokinetics;Central Nervous System Agents/administration \& dosage/*pharmacokinetics;Central Nervous System/*metabolism;Verapamil/administration \& dosage/*pharmacokinetics}
    }
  • Karch R., Neumann F., Ullrich R., Neumüller J., Podesser B.K., Neumann M., Schreiner W.
    The Spatial Pattern of Coronary Capillaries in Patients with Dilated, Ischemic, or Inflammatory Cardiomyopathy.
    Cardiovascular Pathology 14(3), 135–144, (2005) [bib]
    
    @ARTICLE{karch2005spcc135144,
      author = {Karch, R.~ and Neumann, F.~ and Ullrich, R.~ and Neum{\"u}ller, J.~ and Podesser, B.K.~ and Neumann, M.~ and Schreiner, W.~},
      title = {The Spatial Pattern of Coronary Capillaries in Patients with Dilated, Ischemic, or Inflammatory Cardiomyopathy.},
      journal = {Cardiovascular Pathology},
      year = {2005},
      volume = {14},
      number = {3},
      pages = {135--144},
      issn = {1054-8807 1054-8807},
      doi = {10.1016/j.carpath.2005.03.003},
      keywords = {Adult;Female;Humans;Male;Retrospective Studies;Aged;Middle Aged;Models;Biological;Computer Simulation;Capillaries;*Coronary Circulation;Cardiomyopathy;Dilated/*pathology/surgery;Coronary Vessels/*pathology;Heart Failure/pathology/surgery;Heart Transplantation;Myocardial Ischemia/*pathology/surgery;Myocarditis/*pathology/surgery}
    }

2003

  • Karch R., Neumann F., Podesser B.K., Neumann M., Szawlowski P., Schreiner W.
    Fractal Properties of Perfusion Heterogeneity in Optimized Arterial Trees: A Model Study.
    Journal of General Physiology 122(3), 307–321, (2003) [bib]
    
    @ARTICLE{karch2003fpph307321,
      author = {Karch, R.~ and Neumann, F.~ and Podesser, B.K.~ and Neumann, M.~ and Szawlowski, P.~ and Schreiner, W.~},
      title = {Fractal Properties of Perfusion Heterogeneity in Optimized Arterial Trees: A Model Study.},
      journal = {Journal of General Physiology},
      year = {2003},
      volume = {122},
      number = {3},
      pages = {307--321},
      issn = {0022-1295 1540-7748 0022-1295},
      doi = {10.1085/jgp.200208747},
      keywords = {Animals;Computer Simulation;Regional Blood Flow;*Models;Cardiovascular;Arteries/*physiology;*Fractals}
    }
  • Karch R., Neumann F., Neumann M., Szawlowski P., Schreiner W.
    Voronoi Polyhedra Analysis of Optimized Arterial Tree Models.
    Annals of Biomedical Engineering 31(5), 548–563, (2003) [bib]
    
    @ARTICLE{karch2003vpao548563,
      author = {Karch, R.~ and Neumann, F.~ and Neumann, M.~ and Szawlowski, P.~ and Schreiner, W.~},
      title = {Voronoi Polyhedra Analysis of Optimized Arterial Tree Models.},
      journal = {Annals of Biomedical Engineering},
      year = {2003},
      volume = {31},
      number = {5},
      pages = {548--563},
      issn = {0090-6964 0090-6964},
      doi = {10.1114/1.1566444},
      keywords = {Humans;*Algorithms;Models;Statistical;Computer Simulation;Quality Control;Regional Blood Flow/physiology;Retina;*Models;Anatomic;*Models;Cardiovascular;Anatomy;Cross-Sectional/methods;Arteries/*anatomy \& histology/*growth \& development/physiology;Retinal Vessels/physiology}
    }
  • Schreiner W., Karch R., Neumann M., Neumann F., Roedler S.M., Heinze G.
    Heterogeneous Perfusion Is a Consequence of Uniform Shear Stress in Optimized Arterial Tree Models.
    Journal of Theoretical Biology 220(3), 285–301, (2003) [bib]
    
    @ARTICLE{schreiner2003hpia285301,
      author = {Schreiner, W.~ and Karch, R.~ and Neumann, M.~ and Neumann, F.~ and Roedler, S.M.~ and Heinze, G.~},
      title = {Heterogeneous Perfusion Is a Consequence of Uniform Shear Stress in Optimized Arterial Tree Models.},
      journal = {Journal of Theoretical Biology},
      year = {2003},
      volume = {220},
      number = {3},
      pages = {285--301},
      issn = {0022-5193 0022-5193},
      doi = {10.1006/jtbi.2003.3136},
      keywords = {Humans;Stress;Mechanical;Blood Pressure/physiology;*Computer Simulation;*Hemorheology;*Models;Cardiovascular;Arteries/*physiology}
    }

2000

  • Karch R., Neumann F., Neumann M., Schreiner W.
    Functional Characteristics of Optimized Arterial Tree Models Perfusing Volumes of Different Thickness and Shape.
    Journal of Vascular Research 37(4), 250–264, (2000) [bib]
    
    @ARTICLE{karch2000fcoa250264,
      author = {Karch, R.~ and Neumann, F.~ and Neumann, M.~ and Schreiner, W.~},
      title = {Functional Characteristics of Optimized Arterial Tree Models Perfusing Volumes of Different Thickness and Shape.},
      journal = {Journal of Vascular Research},
      year = {2000},
      volume = {37},
      number = {4},
      pages = {250--264},
      issn = {1018-1172 1018-1172},
      doi = {10.1159/000025739},
      keywords = {Computer Simulation;*Models;Cardiovascular;*Blood Circulation;*Blood Volume;Arteries/*anatomy \& histology/*physiology}
    }
  • Karch R., Neumann F., Neumann M., Schreiner W.
    Staged Growth of Optimized Arterial Model Trees.
    Annals of Biomedical Engineering 28(5), 495–511, (2000) [bib]
    
    @ARTICLE{karch2000sgoa495511,
      author = {Karch, R.~ and Neumann, F.~ and Neumann, M.~ and Schreiner, W.~},
      title = {Staged Growth of Optimized Arterial Model Trees.},
      journal = {Annals of Biomedical Engineering},
      year = {2000},
      volume = {28},
      number = {5},
      pages = {495--511},
      issn = {0090-6964 0090-6964},
      doi = {10.1114/1.290},
      keywords = {Algorithms;Humans;Models;Anatomic;*Models;Cardiovascular;Arteries/*anatomy \& histology/*growth \& development/physiology;Biomedical Engineering;Coronary Vessels/anatomy \& histology/growth \& development/physiology;Heart/anatomy \& histology/growth \& development/physiology}
    }

1999

  • Schreiner W., Neumann F., Karch R., Neumann M., Roedler S.M., End A.
    Shear Stress Distribution in Arterial Tree Models, Generated by Constrained Constructive Optimization.
    Journal of Theoretical Biology 198(1), 27–45, (1999) [bib]
    
    @ARTICLE{schreiner1999ssda2745,
      author = {Schreiner, W.~ and Neumann, F.~ and Karch, R.~ and Neumann, M.~ and Roedler, S.M.~ and End, A.~},
      title = {Shear Stress Distribution in Arterial Tree Models, Generated by Constrained Constructive Optimization.},
      journal = {Journal of Theoretical Biology},
      year = {1999},
      volume = {198},
      number = {1},
      pages = {27--45},
      issn = {0022-5193 0022-5193},
      doi = {10.1006/jtbi.1999.0898},
      keywords = {Humans;*Computer Simulation;*Stress;Mechanical;*Models;Cardiovascular;Arteries/*anatomy \& histology;Blood Viscosity/physiology}
    }
  • Karch R., Neumann F., Neumann M., Schreiner W.
    A Three-Dimensional Model for Arterial Tree Representation, Generated by Constrained Constructive Optimization.
    Computers in Biology and Medicine 29(1), 19–38, (1999) [bib]
    
    @ARTICLE{karch1999atma1938,
      author = {Karch, R.~ and Neumann, F.~ and Neumann, M.~ and Schreiner, W.~},
      title = {A Three-Dimensional Model for Arterial Tree Representation, Generated by Constrained Constructive Optimization.},
      journal = {Computers in Biology and Medicine},
      year = {1999},
      volume = {29},
      number = {1},
      pages = {19--38},
      issn = {0010-4825 0010-4825},
      doi = {10.1016/s0010-4825(98)00045-6},
      keywords = {Algorithms;Humans;*Models;Biological;Blood Pressure/physiology;Regional Blood Flow/physiology;*Computer Simulation;Hemodynamics/physiology;Vasoconstriction/physiology;Vascular Resistance/physiology;Vasodilation/physiology;Blood Viscosity/physiology;Arteries/anatomy \& histology/*physiology;Blood Volume/physiology;Microcirculation/physiology;Neovascularization;Physiologic;Stochastic Processes}
    }

1997

  • Schreiner W., Neumann F., Karch R., Neumann M., End A., Roedler S.M.
    Geometrical and Topological Optimization and Their Relation to the Bifurcation Laws in Optimized Arterial Tree Models.
    In Hernandez S., Brebbia C.A. (Eds.) Computer Aided Optimum Design of Structures V. Proceedings of the Fifth International Conference on Computer Aided Optimum Design of Structures (OPTI 97), Rome, Italy, 8–10 September 1997, WIT Transactions on the Built Environment 31, Wit Press, Southampton, 371–380, (1997) [bib]
    
    @INCOLLECTION{schreiner1997gtot371380,
      author = {Schreiner, W.~ and Neumann, F.~ and Karch, R.~ and Neumann, M.~ and End, A.~ and Roedler, S.M.~},
      title = {Geometrical and Topological Optimization and Their Relation to the Bifurcation Laws in Optimized Arterial Tree Models.},
      booktitle = {Computer Aided Optimum Design of Structures V. Proceedings of the Fifth International Conference on Computer Aided Optimum Design of Structures (OPTI 97), Rome, Italy, 8–10 September 1997},
      publisher = {Wit Press},
      year = {1997},
      editor = {Hernandez,S.;Brebbia,C.A.},
      number = {31},
      series = {WIT Transactions on the Built Environment},
      pages = {371--380},
      address = {Southampton},
      url = {https://www.witpress.com/elibrary/wit-transactions-on-the-built-environment/31/8234}
    }
  • Karch R., Schreiner W., Neumann M., Neumann F.
    Three-Dimensional Optimization of Arterial Tree Models.
    In Power H., Brebbia C.H., Kenny J. (Eds.) Simulations in Biomedicine IV. Proceedings of the Fourth International Conference on Computers in Biomedicine (BIOMED), Umbria, Italy, 9–11 June 1997, WIT Transactions on Biomedicine and Health 4, Wit Press, Southampton, 3–12, (1997) [bib]
    
    @INCOLLECTION{karch1997toat312,
      author = {Karch, R.~ and Schreiner, W.~ and Neumann, M.~ and Neumann, F.~},
      title = {Three-Dimensional Optimization of Arterial Tree Models.},
      booktitle = {Simulations in Biomedicine IV. Proceedings of the Fourth International Conference on Computers in Biomedicine (BIOMED), Umbria, Italy, 9–11 June 1997},
      publisher = {Wit Press},
      year = {1997},
      editor = {Power,H.;Brebbia,C.H.;Kenny,J.},
      number = {4},
      series = {WIT Transactions on Biomedicine and Health},
      pages = {3--12},
      address = {Southampton},
      url = {https://www.witpress.com/Secure/elibrary/papers/BIO97/BIO97001FU.pdf}
    }
  • Neumann M., Neumann F., Karch R., Schreiner W.
    Size and Discretization Effects in Simulations of Coronary Hemodynamics.
    In Power H., Brebbia C.H., Kenny J. (Eds.) Simulations in Biomedicine IV. Proceedings of the Fourth International Conference on Computers in Biomedicine (BIOMED), Umbria, Italy, 9–11 June 1997, WIT Transactions on Biomedicine and Health 4, Wit Press, Southampton, 23–35, (1997) [bib]
    
    @INCOLLECTION{neumann1997sdes2335,
      author = {Neumann, M.~ and Neumann, F.~ and Karch, R.~ and Schreiner, W.~},
      title = {Size and Discretization Effects in Simulations of Coronary Hemodynamics.},
      booktitle = {Simulations in Biomedicine IV. Proceedings of the Fourth International Conference on Computers in Biomedicine (BIOMED), Umbria, Italy, 9–11 June 1997},
      publisher = {Wit Press},
      year = {1997},
      editor = {Power,H.;Brebbia,C.H.;Kenny,J.},
      number = {4},
      series = {WIT Transactions on Biomedicine and Health},
      pages = {23--35},
      address = {Southampton},
      url = {https://www.witpress.com/Secure/elibrary/papers/BIO97/BIO97003FU.pdf}
    }
  • Neumann M., Schreiner W., Karch R., Neumann F.
    Structure of Computer-Generated Arterial Trees with Different Optimization Target Functions.
    In Power H., Brebbia C.H., Kenny J. (Eds.) Simulations in Biomedicine IV. Proceedings of the Fourth International Conference on Computers in Biomedicine (BIOMED), Umbria, Italy, 9–11 June 1997, WIT Transactions on Biomedicine and Health 4, Wit Press, Southampton, 37–46, (1997) [bib]
    
    @INCOLLECTION{neumann1997scat3746,
      author = {Neumann, M.~ and Schreiner, W.~ and Karch, R.~ and Neumann, F.~},
      title = {Structure of Computer-Generated Arterial Trees with Different Optimization Target Functions.},
      booktitle = {Simulations in Biomedicine IV. Proceedings of the Fourth International Conference on Computers in Biomedicine (BIOMED), Umbria, Italy, 9–11 June 1997},
      publisher = {Wit Press},
      year = {1997},
      editor = {Power,H.;Brebbia,C.H.;Kenny,J.},
      number = {4},
      series = {WIT Transactions on Biomedicine and Health},
      pages = {37--46},
      address = {Southampton},
      url = {https://www.witpress.com/Secure/elibrary/papers/BIO97/BIO97004FU.pdf}
    }
  • Schreiner W., Neumann F., Neumann M., Karch R.
    Local Symmetry and Global Structure of Coronary Arterial Tree Models Generated by Constrained Constructive Optimization.
    In Power H., Brebbia C.H., Kenny J. (Eds.) Simulations in Biomedicine IV. Proceedings of the Fourth International Conference on Computers in Biomedicine (BIOMED), Umbria, Italy, 9–11 June 1997, WIT Transactions on Biomedicine and Health 4, Wit Press, Southampton, 125–134, (1997) [bib]
    
    @INCOLLECTION{schreiner1997lsgs125134,
      author = {Schreiner, W.~ and Neumann, F.~ and Neumann, M.~ and Karch, R.~},
      title = {Local Symmetry and Global Structure of Coronary Arterial Tree Models Generated by Constrained Constructive Optimization.},
      booktitle = {Simulations in Biomedicine IV. Proceedings of the Fourth International Conference on Computers in Biomedicine (BIOMED), Umbria, Italy, 9–11 June 1997},
      publisher = {Wit Press},
      year = {1997},
      editor = {Power,H.;Brebbia,C.H.;Kenny,J.},
      number = {4},
      series = {WIT Transactions on Biomedicine and Health},
      pages = {125--134},
      address = {Southampton},
      url = {https://www.witpress.com/Secure/elibrary/papers/BIO97/BIO97012FU.pdf}
    }
  • Schreiner W., Neumann F., Neumann M., Karch R., End A., Roedler S.M.
    Limited Bifurcation Asymmetry in Coronary Arterial Tree Models Generated by Constrained Constructive Optimization.
    Journal of General Physiology 109(2), 129–140, (1997) [bib]
    
    @ARTICLE{schreiner1997lbac129140,
      author = {Schreiner, W.~ and Neumann, F.~ and Neumann, M.~ and Karch, R.~ and End, A.~ and Roedler, S.M.~},
      title = {Limited Bifurcation Asymmetry in Coronary Arterial Tree Models Generated by Constrained Constructive Optimization.},
      journal = {Journal of General Physiology},
      year = {1997},
      volume = {109},
      number = {2},
      pages = {129--140},
      issn = {0022-1295 1540-7748 0022-1295},
      doi = {10.1085/jgp.109.2.129},
      keywords = {Algorithms;Linear Models;Computer Simulation;Regression Analysis;Models;Anatomic;Blood Pressure/physiology;Coronary Circulation/physiology;Coronary Vessels/*anatomy \& histology/physiology;Viscosity}
    }

1996

  • Neumann F., Neumann M., Karch R., Schreiner W.
    Visualization of Computer-Generated Arterial Model Trees.
    In Cerrolaza M., Jugo D., Brebbia C.A. (Eds.) Simulation Modelling in Bioengineering. Proceedings of the First International BIOSIM ’96 Conference, Mérida, Venezuela, 23–25 October 1996, WIT Transactions on Biomedicine and Health 3, WIT Press, Southampton, 259–268, (1996) [bib]
    
    @INCOLLECTION{neumann1996vcam259268,
      author = {Neumann, F.~ and Neumann, M.~ and Karch, R.~ and Schreiner, W.~},
      title = {Visualization of Computer-Generated Arterial Model Trees.},
      booktitle = {Simulation Modelling in Bioengineering. Proceedings of the First International BIOSIM ’96 Conference, Mérida, Venezuela, 23–25 October 1996},
      publisher = {WIT Press},
      year = {1996},
      editor = {Cerrolaza,M.;Jugo,D.;Brebbia,C.A.},
      number = {3},
      series = {WIT Transactions on Biomedicine and Health},
      pages = {259--268},
      address = {Southampton},
      url = {https://www.witpress.com/Secure/elibrary/papers/BSIM96/BSIM96024FU.pdf}
    }
  • Neumann M., Neumann F., Karch R., Schreiner W.
    Spatially Resolved Simulation of Coronary Hemodynamics.
    In Cerrolaza M., Jugo D., Brebbia C.A. (Eds.) Simulation Modelling in Bioengineering. Proceedings of the First International BIOSIM ’96 Conference, Mérida, Venezuela, 23–25 October 1996, WIT Transactions on Biomedicine and Health 3, WIT Press, Southampton, 39–51, (1996) [bib]
    
    @INCOLLECTION{neumann1996srsc3951,
      author = {Neumann, M.~ and Neumann, F.~ and Karch, R.~ and Schreiner, W.~},
      title = {Spatially Resolved Simulation of Coronary Hemodynamics.},
      booktitle = {Simulation Modelling in Bioengineering. Proceedings of the First International BIOSIM ’96 Conference, Mérida, Venezuela, 23–25 October 1996},
      publisher = {WIT Press},
      year = {1996},
      editor = {Cerrolaza,M.;Jugo,D.;Brebbia,C.A.},
      number = {3},
      series = {WIT Transactions on Biomedicine and Health},
      pages = {39--51},
      address = {Southampton},
      url = {https://www.witpress.com/Secure/elibrary/papers/BSIM96/BSIM96004FU.pdf}
    }