Publications

@ARTICLE{schreiner2023cmdc39203932,
  author = {Schreiner, W.~ and Karch, R.~ and Cibena, M.~ and Tomasiak, L.~ and Kenn, M.~ and Pfeiler, G.~},
  title = {Clustering Molecular Dynamics Conformations of the CC’-Loop of the PD-1 Immuno-Checkpoint Receptor.},
  journal = {Computational and Structural Biotechnology Journal},
  year = {2023},
  volume = {21},
  pages = {3920--3932},
  doi = {10.1016/j.csbj.2023.07.004}
}

@ARTICLE{kenn2023frec119,
  author = {Kenn, M.~ and Karch, R.~ and Singer, C.F.~ and Dorffner, G.~ and Schreiner, W.~},
  title = {Flexible Risk Evidence Combination Rules in Breast Cancer Precision Therapy.},
  journal = {Journal of Personalized Medicine},
  year = {2023},
  volume = {13},
  number = {1},
  pages = {119},
  issn = {2075-4426},
  doi = {10.3390/jpm13010119},
  keywords = {precision medicine;personalized medicine;data science;breast cancer;mathematical oncology;Dempster-Shafer theory;evidence theory;hormone receptor status;theory of belief functions}
}

@INCOLLECTION{schreiner2022pupl35693573,
  author = {Schreiner, W.~ and Karch, R.~ and Cibena, M.~ and Tomasiak, L.~ and Kenn, M.~ and Pfeiler, G.~},
  title = {The Performance of UMAP Plus Linkage Compared with Daura-Clustering of Molecular Dynamics of the PD-1 Checkpoint Receptor.},
  booktitle = {Proceedings 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Las Vegas, USA \& Changsha, China, 6–8 December 2022},
  publisher = {Institute of Electrical and Electronics Engineers (IEEE)},
  year = {2022},
  editor = {Adjeroh,D.;Long,Q.;Shi,X.;Guo,F.;Hu,X.;Aluru,S.;Narasimhan,G.;Wang,J.;Kang,M.;Mondal,A.M.;Liu,J.},
  pages = {3569--3573},
  address = {Piscataway, NJ},
  month = {dec},
  url = {https://www.doi.org/10.1109/BIBM55620.2022.9995272}
}

@ARTICLE{kenn2022mdis838129,
  author = {Kenn, M.~ and Karch, R.~ and Tomasiak, L.~ and Cibena, M.~ and Pfeiler, G.~ and Koelbl, H.~ and Schreiner, W.~},
  title = {Molecular Dynamics Identifies Semi-Rigid Domains in the PD-1 Checkpoint Receptor Bound to Its Natural Ligand PD-L1.},
  journal = {Frontiers in Bioengineering and Biotechnology},
  year = {2022},
  volume = {10},
  pages = {838129},
  issn = {2296-4185},
  doi = {10.3389/fbioe.2022.838129},
  keywords = {molecular dynamics;oncology;checkpoint inhibitor;cluster analysis;drug design;immune therapy}
}

@ARTICLE{tomasiak2022cfaf36,
  author = {Tomasiak, L.~ and Karch, R.~ and Schreiner, W.~},
  title = {Conformational Flexibility of a Free and TCR-Bound pMHC-I Protein Investigated by Long-Term Molecular Dynamics Simulations.},
  journal = {BMC Immunology},
  year = {2022},
  volume = {23},
  number = {Suppl 1: Selected Papers 4th International Workshop on Computational Methods for the Immune System Function (CMISF 2020): Immunology, Virtual, 16–19 December 2020},
  pages = {36},
  doi = {10.1186/s12865-022-00510-7}
}

@ARTICLE{kenn2022dtvc570,
  author = {Kenn, M.~ and Karch, R.~ and Cacsire Castillo-Tong, D.~ and Singer, C.F.~ and Koelbl, H.~ and Schreiner, W.~},
  title = {Decision Theory versus Conventional Statistics for Personalized Therapy of Breast Cancer.},
  journal = {Journal of Personalized Medicine},
  year = {2022},
  volume = {12},
  number = {4},
  pages = {570},
  issn = {2075-4426},
  doi = {10.3390/jpm12040570},
  keywords = {precision medicine;biomarkers;personalized medicine;data science;breast cancer;gene expression;mathematical oncology;receptor status;decision theory}
}

@ARTICLE{hernándezlozano2021iate105854,
  author = {Hernández-Lozano, I.~ and Wanek, T.~ and Sauberer, M.~ and Filip, T.~ and Mairinger, S.~ and Stanek, J.~ and Traxl, A.~ and Karch, R.~ and Schuetz, J.D.~ and Langer, O.~},
  title = {Influence of ABC Transporters on the Excretion of Ciprofloxacin Assessed with PET Imaging in Mice.},
  journal = {European Journal of Pharmaceutical Sciences},
  year = {2021},
  volume = {163},
  pages = {105854},
  issn = {1879-0720 0928-0987},
  doi = {10.1016/j.ejps.2021.105854},
  keywords = {Positron emission tomography;[(18)F]Ciprofloxacin;Breast cancer resistance protein (BCRP);Multidrug resistance-associated protein 4 (MRP4);Pharmacokinetic modelling;Tubular secretion}
}

@ARTICLE{elbiali2021aatl698966,
  author = {El Biali, M.~ and Karch, R.~ and Philippe, C.~ and Haslacher, H.~ and Tournier, N.~ and Hacker, M.~ and Zeitlinger, M.~ and Schmidl, D.~ and Langer, O.~ and Bauer, M.~},
  title = {ABCB1 and ABCG2 Together Limit the Distribution of ABCB1/ABCG2 Substrates to the Human Retina and the ABCG2 Single Nucleotide Polymorphism Q141K (c.421C> A) May Lead to Increased Drug Exposure.},
  journal = {Frontiers in Pharmacology},
  year = {2021},
  volume = {12},
  pages = {698966},
  issn = {1663-9812},
  doi = {10.3389/fphar.2021.698966},
  keywords = {human;PET;tariquidar;single-nucleotide polymorphism;ABCB1;ABCG2;blood-retinal barrier;c421C{	extgreater}A}
}

@ARTICLE{kenn2021eswe7072,
  author = {Kenn, M~ and Cacsire Castillo-Tong, D.~ and Singer, C.F.~ and Karch, R.~ and Cibena, M.~ and K{\"o}lbl, H.~ and Schreiner, W.~},
  title = {Evidenz statt Wahrscheinlichkeiten: Entscheidungstheorie f{\"u}r die Pr{\"a}zisionsmedizin.},
  journal = {Spectrum Onkologie},
  year = {2021},
  volume = {2/2021},
  pages = {70--72},
  url = {https://www.medmedia.at/apps/download/download_pdf.php?file=wp-content/uploads/2021/04/so-2021-02-lr.pdf#page=70}
}

@ARTICLE{kenn2021dtpt4233,
  author = {Kenn, M.~ and Cacsire Castillo-Tong, D.~ and Singer, C.F.~ and Karch, R.~ and Cibena, M.~ and Koelbl, H.~ and Schreiner, W.~},
  title = {Decision Theory for Precision Therapy of Breast Cancer.},
  journal = {Scientific Reports},
  year = {2021},
  volume = {11},
  pages = {4233},
  issn = {2045-2322},
  doi = {10.1038/s41598-021-82418-7}
}

@INPROCEEDINGS{tomasiak2020lmds12951302,
  author = {Tomasiak, L.~ and Karch, R.~ and Schreiner, W.~},
  title = {Long-Term Molecular Dynamics Simulations Reveal Flexibility Properties of a Free and TCR-Bound pMHC-I System.},
  booktitle = {Proceedings 2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Seoul, Korea, 16–19 December 2020},
  year = {2020},
  editor = {Park,T.;Cho,Y.-R.;Hu,X.;Yoo,I.;Woo,H.G.;Wang,J.;Facelli,J.;Nam,S.;Kang,M.},
  pages = {1295--1302},
  address = {Piscataway, NJ},
  publisher = {IEEE},
  doi = {10.1109/BIBM49941.2020.9313545},
  url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100345478\&doi=10.1109%2fBIBM49941.2020.9313545\&partnerID=40\&md5=2948b457d9ecfeba2799c184a625635b}
}

@ARTICLE{buchtele2020stpp979990,
  author = {Buchtele, N.~ and Schwameis, M.~ and Schoergenhofer, C.~ and Derhaschnig, U.~ and Firbas, C.~ and Karch, R.~ and Nix, D.~ and Schenk, R.~ and Jilma, B.~},
  title = {Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Parenterally Administered Dutogliptin: A Prospective Dose-Escalating Trial.},
  journal = {British Journal of Clinical Pharmacology},
  year = {2020},
  volume = {86},
  number = {5},
  pages = {979--990},
  issn = {0306-5251},
  doi = {10.1111/bcp.14208},
  url = {https://doi.org/10.1111/bcp.14208},
  keywords = {dutogliptin;healthy;parenteral;pharmacokinetics/pharmacodynamics;safety}
}

@ARTICLE{wulkersdorfer2019abda110,
  author = {Wulkersdorfer, B.~ and Bauer, M.~ and Karch, R.~ and Stefanits, H.~ and Philippe, C.~ and Weber, M.~ and Czech, T.~ and Menet, M.-C.~ and Declèves, X.~ and Hainfellner, J.A.~ and Preusser, M.~ and Hacker, M.~ and Zeitlinger, M.~ and M{\"u}ller, M.~ and Langer, O.~},
  title = {Assessment of Brain Delivery of a Model ABCB1/ABCG2 Substrate in Patients with Non-Contrast-Enhancing Brain Tumors with Positron Emission Tomography.},
  journal = {EJNMMI Research},
  year = {2019},
  volume = {9},
  pages = {110},
  doi = {10.1186/s13550-019-0581-y},
  url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076350408\&doi=10.1186%2fs13550-019-0581-y\&partnerID=40\&md5=51e3132dea24ea67d80b0b1a079ed8d8}
}

@ARTICLE{karch2019idmf720,
  author = {Karch, R.~ and Stocsits, C.~ and Ilieva, N.~ and Schreiner, W.~},
  title = {Intramolecular Domain Movements of Free and Bound pMHC and TCR Proteins: A Molecular Dynamics Simulation Study.},
  journal = {Cells},
  year = {2019},
  volume = {8},
  number = {7},
  pages = {720},
  issn = {2073-4409 2073-4409},
  doi = {10.3390/cells8070720},
  keywords = {Humans;*antigen;*domain movements;*major histocompatibility complex;*Major Histocompatibility Complex;*molecular dynamics simulation;*T-cell receptor;Binding Sites;Molecular Dynamics Simulation;Peptides/*chemistry;Protein Binding;Protein Conformation;Receptors;Antigen;T-Cell;alpha-beta/*chemistry}
}

@ARTICLE{hernándezlozano2019tipm61,
  author = {Hernández Lozano, I.~ and Karch, R.~ and Bauer, M.~ and Blaickner, M.~ and Matsuda, A.~ and Wulkersdorfer, B.~ and Hacker, M.~ and Zeitlinger, M.~ and Langer, O.~},
  title = {Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography.},
  journal = {AAPS Journal},
  year = {2019},
  volume = {21},
  number = {4},
  pages = {61},
  doi = {10.1208/s12248-019-0323-0},
  url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065136123\&doi=10.1208%2fs12248-019-0323-0\&partnerID=40\&md5=28c8d4906aa021eed9c80f8bf4d0dde5}
}

@ARTICLE{tournier2019ipfb985991,
  author = {Tournier, N.~ and Bauer, M.~ and Pichler, V.~ and Nics, L.~ and Klebermass, E.-M.~ and Bamminger, K.~ and Matzneller, P.~ and Weber, M.~ and Karch, R.~ and Caillé, F.~ and Auvity, S.~ and Marie, S.~ and J{\"a}ger, W.~ and Wadsak, W.~ and Hacker, M.~ and Zeitlinger, M.~ and Langer, O.~},
  title = {Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate 11C-Metoclopramide Assessed with PET Imaging in Humans.},
  journal = {Journal of Nuclear Medicine},
  year = {2019},
  volume = {60},
  number = {7},
  pages = {985--991},
  issn = {1535-5667 0161-5505},
  doi = {10.2967/jnumed.118.219972},
  keywords = {11C-metoclopramide;blood-brain barrier;P-glycoprotein;PET}
}

@ARTICLE{bauer2019apst486491,
  author = {Bauer, M.~ and Karch, R.~ and Wulkersdorfer, B.~ and Philippe, C.~ and Nics, L.~ and Klebermass, E.-M.~ and Weber, M.~ and Poschner, S.~ and Haslacher, H.~ and J{\"a}ger, W.~ and Tournier, N.~ and Wadsak, W.~ and Hacker, M.~ and Zeitlinger, M.~ and Langer, O.~},
  title = {A Proof-of-Concept Study to Inhibit ABCG2- and ABCB1-Mediated Efflux Transport at the Human Blood-Brain Barrier.},
  journal = {Journal of Nuclear Medicine},
  year = {2019},
  volume = {60},
  number = {4},
  pages = {486--491},
  issn = {1535-5667 0161-5505},
  doi = {10.2967/jnumed.118.216432},
  keywords = {blood-brain barrier;P-glycoprotein;PET;11C-erlotinib;breast cancer resistance protein}
}

@ARTICLE{simeone2019rns5e14023,
  author = {Simeone, X.~ and Karch, R.~ and Ciuraszkiewicz, A.~ and Orr-Urtreger, A.~ and Lemmens-Gruber, R.~ and Scholze, P.~ and Huck, S.~},
  title = {The Role of the nAChR Subunits α5, β2, and β4 on Synaptic Transmission in the Mouse Superior Cervical Ganglion.},
  journal = {Physiological Reports},
  year = {2019},
  volume = {7},
  number = {6},
  pages = {e14023},
  issn = {2051-817X 2051-817X},
  doi = {10.14814/phy2.14023},
  keywords = {* EPSP;*Compound action potential;*Hexamethonium;*knockout mice;*nicotinic ACh receptor;*superior cervical ganglion;*synaptic transmission}
}

@ARTICLE{bauer2018erd[45894598,
  author = {Bauer, M.~ and Traxl, A.~ and Matsuda, A.~ and Karch, R.~ and Philippe, C.~ and Nics, L.~ and Klebermass, E.-M.~ and Wulkersdorfer, B.~ and Weber, M.~ and Poschner, S.~ and Tournier, N.~ and J{\"a}ger, W.~ and Wadsak, W.~ and Hacker, M.~ and Wanek, T.~ and Zeitlinger, M.~ and Langer, O.~},
  title = {Effect of Rifampicin on the Distribution of [11C]Erlotinib to the Liver, a Translational PET Study in Humans and in Mice.},
  journal = {Molecular Pharmaceutics},
  year = {2018},
  volume = {15},
  number = {10},
  pages = {4589--4598},
  issn = {1543-8384},
  doi = {10.1021/acs.molpharmaceut.8b00588},
  url = {https://doi.org/10.1021/acs.molpharmaceut.8b00588}
}

@ARTICLE{bauer2017epia19911999,
  author = {Bauer, M.~ and Wulkersdorfer, B.~ and Karch, R.~ and Philippe, C.~ and J{\"a}ger, W.~ and Stanek, J.~ and Wadsak, W.~ and Hacker, M.~ and Zeitlinger, M.~ and Langer, O.~},
  title = {Effect of P-Glycoprotein Inhibition at the Blood–Brain Barrier on Brain Distribution of (R)-[11C]Verapamil in Elderly vs. Young Subjects.},
  journal = {British Journal of Clinical Pharmacology},
  year = {2017},
  volume = {83},
  number = {9},
  pages = {1991--1999},
  issn = {0306-5251},
  doi = {10.1111/bcp.13301},
  keywords = {age;alzheimers-disease;blood-brain barrier;P-glycoprotein;pet;positron-emission-tomography;drug-drug interactions;drug-drug interaction;epilepsy;pilot pet;resistance protein bcrp/abcg2;substrate;tariquidar;transporters}
}

@ARTICLE{matsuda2017apmp27802786,
  author = {Matsuda, A.~ and Karch, R.~ and Bauer, M.~ and Traxl, A.~ and Zeitlinger, M.~ and Langer, O.~},
  title = {A Prediction Method for P-Glycoprotein–Mediated Drug–Drug Interactions at the Human Blood–Brain Barrier from Blood Concentration–Time Profiles, Validated with PET Data.},
  journal = {Journal of Pharmaceutical Sciences},
  year = {2017},
  volume = {106},
  number = {9},
  pages = {2780--2786},
  issn = {0022-3549},
  doi = {10.1016/j.xphs.2017.03.024},
  keywords = {blood-brain barrier;P-glycoprotein;pet;positron-emission-tomography;tariquidar;transporters;ABC transporters;cancer resistance protein;clearance;drug-drug interactions;inhibition;multi;pharmacokinetics;physiologically based pharmacokinetic model;receptors;tissue distribution}
}

@ARTICLE{bauer2017apta678681,
  author = {Bauer, M.~ and Karch, R.~ and Tournier, N.~ and Cisternino, S.~ and Wadsak, W.~ and Hacker, M.~ and Marhofer, P.~ and Zeitlinger, M.~ and Langer, O.~},
  title = {Assessment of P-Glycoprotein Transport Activity at the Human Blood–Retina Barrier with (R)-11C-Verapamil PET.},
  journal = {Journal of Nuclear Medicine},
  year = {2017},
  volume = {58},
  number = {4},
  pages = {678--681},
  issn = {0161-5505},
  doi = {10.2967/jnumed.116.182147},
  keywords = {blood-brain barrier;P-glycoprotein;binding;pet;inhibition;blood-retina barrier;brain-barrier;carrier;eye}
}

@ARTICLE{bauer2016ppst131141,
  author = {Bauer, M.~ and R{\"o}mermann, K.~ and Karch, R.~ and Wulkersdorfer, B.~ and Stanek, J.~ and Philippe, C.~ and Maier-Salamon, A.~ and Haslacher, H.~ and Jungbauer, C.~ and Wadsak, W.~ and J{\"a}ger, W.~ and L{\"o}scher, W.~ and Hacker, M.~ and Zeitlinger, M.~ and Langer, O.~},
  title = {Pilot PET Study to Assess the Functional Interplay between ABCB1 and ABCG2 at the Human Blood–Brain Barrier.},
  journal = {Clinical Pharmacology \& Therapeutics},
  year = {2016},
  volume = {100},
  number = {2},
  pages = {131--141},
  issn = {0009-9236},
  doi = {10.1002/cpt.362},
  keywords = {positron-emission-tomography;cancer resistance protein;drug-drug interactions;inhibition;bcrp gene polymorphisms;efflux;p-glycoprotein activity;quantitative atlas;radiotracer;transport activity}
}

@ARTICLE{kenn2016smcc16001614,
  author = {Kenn, M.~ and Ribarics, R.~ and Ilieva, N.~ and Cibena, M.~ and Karch, R.~ and Schreiner, W.~},
  title = {Spatiotemporal Multistage Consensus Clustering in Molecular Dynamics Studies of Large Proteins.},
  journal = {Molecular BioSystems},
  year = {2016},
  volume = {12},
  number = {5},
  pages = {1600--1614},
  issn = {1742-2051 1742-2051},
  doi = {10.1039/c5mb00879d},
  keywords = {Algorithms;Protein Conformation;*Cluster Analysis;*Molecular Dynamics Simulation;CD8 Antigens/chemistry/metabolism;Major Histocompatibility Complex;Models;Molecular;Multiprotein Complexes/chemistry;Protein Interaction Domains and Motifs;Proteins/*chemistry/metabolism;Receptors;Antigen;T-Cell/chemistry/metabolism}
}

@ARTICLE{bauer2016optla12,
  author = {Bauer, M.~ and Feldmann, M.~ and Karch, R.~ and Zeitlinger, M.~ and Koepp, M.J.~ and Asselin, M.-C.~ and Pataraia, E.~ and Langer, O.~},
  title = {Outcome Prediction of Temporal Lobe Epilepsy Surgery from P-Glycoprotein Activity Pooled Analysis of (R)-[11C]-Verapamil PET Data from Two European Centres.},
  journal = {EJNMMI Research},
  year = {2016},
  volume = {6},
  number = {Suppl 1: Abstracts 32nd International Austrian Winter Symposium, Zell am See, Austria, 20–23 January 2016},
  pages = {A12},
  issn = {2191-219X},
  url = {https://ejnmmires.springeropen.com/articles/10.1186/s13550-016-0168-9#Sec34}
}

@ARTICLE{schreiner2015rmdl210675,
  author = {Schreiner, W.~ and Karch, R.~ and Ribarics, R.~ and Cibena, M.~ and Ilieva, N.~},
  title = {Relative Movements of Domains in Large Molecules of the Immune System.},
  journal = {Journal of Immunology Research},
  year = {2015},
  volume = {2015},
  pages = {210675},
  issn = {2314-7156 2314-8861 2314-7156},
  doi = {10.1155/2015/210675},
  keywords = {Humans;Mutation;Binding Sites;Protein Binding;*Molecular Dynamics Simulation;Protein Interaction Domains and Motifs;beta 2-Microglobulin/*chemistry/immunology;CD8 Antigens/*chemistry/immunology;HLA-B27 Antigen/*chemistry/immunology;Immunological Synapses/chemistry/immunology;Least-Squares Analysis;Peptides/*chemistry/immunology;Protein Structure;Secondary;Receptors;Antigen;T-Cell;alpha-beta/*chemistry/immunology;Structural Homology;Protein}
}

@ARTICLE{ribarics2015gdhd173593,
  author = {Ribarics, R.~ and Kenn, M.~ and Karch, R.~ and Ilieva, N.~ and Schreiner, W.~},
  title = {Geometry Dynamics of α-Helices in Different Class I Major Histocompatibility Complexes.},
  journal = {Journal of Immunology Research},
  year = {2015},
  volume = {2015},
  pages = {173593},
  issn = {2314-7156 2314-8861 2314-7156},
  doi = {10.1155/2015/173593},
  keywords = {Humans;Mutation;Binding Sites;Protein Binding;*Molecular Dynamics Simulation;Protein Interaction Domains and Motifs;HLA-B27 Antigen/*chemistry/immunology;Immunological Synapses/chemistry/immunology;Least-Squares Analysis;Peptides/*chemistry/immunology;Protein Structure;Secondary;Receptors;Antigen;T-Cell/*chemistry/immunology}
}

@ARTICLE{bauer2015acip743746,
  author = {Bauer, M.~ and Karch, R.~ and Zeitlinger, M.~ and Philippe, C.~ and R{\"o}mermann, K.~ and Stanek, J.~ and Maier-Salamon, A.~ and Wadsak, W.~ and J{\"a}ger, W.~ and Hacker, M.~ and M{\"u}ller, M.~ and Langer, O.~},
  title = {Approaching Complete Inhibition of P-Glycoprotein at the Human Blood-Brain Barrier: An (R)-[11C]Verapamil PET Study.},
  journal = {Journal of Cerebral Blood Flow and Metabolism},
  year = {2015},
  volume = {35},
  number = {5},
  pages = {743--746},
  issn = {1559-7016 0271-678X 0271-678X},
  doi = {10.1038/jcbfm.2015.19},
  keywords = {Humans;Male;Middle Aged;Radiography;Verapamil/*administration \& dosage;*Blood-Brain Barrier/diagnostic imaging/metabolism;*Gray Matter/diagnostic imaging/metabolism;*Pituitary Gland/diagnostic imaging/metabolism;Anti-Arrhythmia Agents/administration \& dosage;ATP Binding Cassette Transporter;Subfamily B/antagonists \& inhibitors/metabolism;Carbon Isotopes/administration \& dosage;Positron-Emission Tomography;Radiopharmaceuticals/*administration \& dosage}
}

@ARTICLE{bauer2014vpfb13261331,
  author = {Bauer, M.~ and Karch, R.~ and Zeitlinger, M.~ and Liu, J.~ and Koepp, M.J.~ and Asselin, M.-C.~ and Sisodiya, S.M.~ and Hainfellner, J.A.~ and Wadsak, W.~ and Mitterhauser, M.~ and M{\"u}ller, M.~ and Pataraia, E.~ and Langer, O.~},
  title = {In Vivo P-Glycoprotein Function before and after Epilepsy Surgery.},
  journal = {Neurology},
  year = {2014},
  volume = {83},
  number = {15},
  pages = {1326--1331},
  issn = {1526-632X 0028-3878 0028-3878},
  doi = {10.1212/WNL.0000000000000858},
  keywords = {Adult;Female;Humans;Male;Middle Aged;Pilot Projects;Postoperative Period;Drug Resistance;Preoperative Period;Positron-Emission Tomography;Anticonvulsants;ATP Binding Cassette Transporter;Subfamily B;Member 1/*metabolism;Carbon Radioisotopes;Epilepsy;Temporal Lobe/diagnostic imaging/*metabolism/*surgery;Functional Neuroimaging;Hippocampus/metabolism;Temporal Lobe/diagnostic imaging/*metabolism;Verapamil}
}

@ARTICLE{ribarics2014gaah943186,
  author = {Ribarics, R.~ and Karch, R.~ and Ilieva, N.~ and Schreiner, W.~},
  title = {Geometric Analysis of Alloreactive HLA α-Helices.},
  journal = {BioMed Research International},
  year = {2014},
  volume = {2014},
  pages = {943186},
  issn = {2314-6141 2314-6133},
  doi = {10.1155/2014/943186},
  keywords = {Humans;*Molecular Dynamics Simulation;Protein Structure;Secondary;HLA Antigens/*chemistry}
}

@ARTICLE{bauer2013i<11C-Tariquidar and 11C-Elacridar with P-Glycoprotein and Breast Cancer Resistance Protein at the Human Blood–Brain Barrier.},
  journal = {Journal of Nuclear Medicine},
  year = {2013},
  volume = {54},
  number = {8},
  pages = {1181--1187},
  issn = {1535-5667 0161-5505 0161-5505},
  doi = {10.2967/jnumed.112.118232},
  keywords = {Adult;Humans;Male;Protein Binding;blood-brain barrier;P-glycoprotein;breast cancer resistance protein;Positron-Emission Tomography;ATP Binding Cassette Transporter;Subfamily B;Member 1/*metabolism;Carbon Radioisotopes;11C-elacridar;11C-tariquidar;Acridines/*metabolism;ATP Binding Cassette Transporter;Subfamily G;Member 2;ATP-Binding Cassette Transporters/*metabolism;Blood-Brain Barrier/diagnostic imaging/*metabolism;Neoplasm Proteins/*metabolism;Quinolines/*metabolism;Tetrahydroisoquinolines/*metabolism}
}

@ARTICLE{muellauer2013acpe755763,
  author = {M{\"u}llauer, J.~ and Karch, R.~ and Bankstahl, J.P.~ and Bankstahl, M.~ and Stanek, J.~ and Wanek, T.~ and Mairinger, S.~ and M{\"u}ller, M.~ and L{\"o}scher, W.~ and Langer, O.~ and Kuntner, C.~},
  title = {Assessment of Cerebral P-Glycoprotein Expression and Function with PET by Combined [11C]Inhibitor and [11C]Substrate Scans in Rats.},
  journal = {Nuclear Medicine and Biology},
  year = {2013},
  volume = {40},
  number = {6},
  pages = {755--763},
  issn = {1872-9614 0969-8051},
  doi = {10.1016/j.nucmedbio.2013.05.005},
  keywords = {Animals;Female;Rats;Kinetics;Rats;Sprague-Dawley;P-glycoprotein;*Gene Expression Regulation;Carbon Radioisotopes;(R)-[(11)C]verapamil;[(11)C]elacridar;[(11)C]tariquidar;Acridines/metabolism/pharmacology;ATP Binding Cassette Transporter;Subfamily B;Member 1/*antagonists \& inhibitors/*metabolism;Biological Transport;Blood–brain barrier;Brain/*metabolism;Positron emission tomography;Positron-Emission Tomography/*methods;Quinolines/metabolism/pharmacology;Tetrahydroisoquinolines/metabolism/pharmacology;Verapamil/metabolism}
}

@ARTICLE{bauer2013fhbi11,
  author = {Bauer, M.~ and Zeitlinger, M.~ and Karch, R.~ and Philippe, C.~ and Wadsak, W.~ and Mitterhauser, M.~ and Karanikas, G.~ and Mueller, M.~ and Langer, O.~},
  title = {First Human Brain Imaging of C-11-Tariquidar and C-11-Elacridar to Measure the Function of P-Glycoprotein and Breast Cancer Resistance Protein.},
  journal = {British Journal of Clinical Pharmacology},
  year = {2013},
  volume = {75},
  number = {Suppl 1: Abstracts 2012 Joint Annual Meeting of the German and Austrian Societies for Clinical Pharmacology and Toxicology, Stuttgart, Germany, 19–23 October 2012},
  pages = {1},
  issn = {0306-5251},
  doi = {10.1111/bcp.12067}
}

@ARTICLE{sauermann2012apcc14191423,
  author = {Sauermann, R.~ and Feurstein, T.~ and Karch, R.~ and Kjellsson, M.C.~ and J{\"a}ger, W.~ and B{\"o}hmdorfer, M.~ and P{\"u}sp{\"o}k, A.~ and Langenberger, H.~ and Wild, T.~ and Winkler, S.~ and Zeitlinger, M.~},
  title = {Abscess Penetration of Cefpirome: Concentrations and Simulated Pharmacokinetic Profiles in Pus.},
  journal = {European Journal of Clinical Pharmacology},
  year = {2012},
  volume = {68},
  number = {10},
  pages = {1419--1423},
  issn = {1432-1041},
  doi = {10.1007/s00228-012-1270-1},
  url = {https://doi.org/10.1007/s00228-012-1270-1}
}

@ARTICLE{sauermann2012gpmi146150,
  author = {Sauermann, R.~ and Karch, R.~ and Kjellsson, M.C.~ and Feurstein, T.~ and P{\"u}sp{\"o}k, A.~ and Langenberger, H.~ and B{\"o}hmdorfer, M.~ and J{\"a}ger, W.~ and Zeitlinger, M.~},
  title = {Good Penetration of Moxifloxacin into Human Abscesses.},
  journal = {Pharmacology},
  year = {2012},
  volume = {90},
  number = {3-4},
  pages = {146--150},
  issn = {1423-0313 0031-7012},
  doi = {10.1159/000341550},
  keywords = {Adult;Female;Humans;Male;Middle Aged;Microbial Sensitivity Tests;Abscess/*drug therapy/metabolism;Anti-Infective Agents/*pharmacokinetics;Aza Compounds/*pharmacokinetics/pharmacology;Fluoroquinolones;Moxifloxacin;Quinolines/*pharmacokinetics/pharmacology}
}

@ARTICLE{schreiner2012rerm173521,
  author = {Schreiner, W.~ and Karch, R.~ and Knapp, B.~ and Ilieva, N.~},
  title = {Relaxation Estimation of RMSD in Molecular Dynamics Immunosimulations.},
  journal = {Computational and Mathematical Methods in Medicine},
  year = {2012},
  volume = {2012},
  pages = {173521},
  issn = {1748-6718 1748-670X 1748-670X},
  doi = {10.1155/2012/173521},
  keywords = {Algorithms;Animals;Humans;Time Factors;Reproducibility of Results;Models;Statistical;Models;Theoretical;Computer Simulation;Computational Biology/*methods;*Molecular Dynamics Simulation;Models;Molecular;Immune System/chemistry;Molecular Conformation;Proteins/chemistry;Receptors;Antigen;T-Cell/chemistry}
}

@ARTICLE{bauer2012pibr227233,
  author = {Bauer, M.~ and Zeitlinger, M.~ and Karch, R.~ and Matzneller, P.~ and Stanek, J.~ and J{\"a}ger, W.~ and B{\"o}hmdorfer, M.~ and Wadsak, W.~ and Mitterhauser, M.~ and Bankstahl, J.P.~ and L{\"o}scher, W.~ and Koepp, M.~ and Kuntner, C.~ and M{\"u}ller, M.~ and Langer, O.~},
  title = {Pgp-Mediated Interaction between (R)-[11C]Verapamil and Tariquidar at the Human Blood–Brain Barrier: A Comparison with Rat Data.},
  journal = {Clinical Pharmacology and Therapeutics},
  year = {2012},
  volume = {91},
  number = {2},
  pages = {227--233},
  issn = {1532-6535 0009-9236 0009-9236},
  doi = {10.1038/clpt.2011.217},
  keywords = {Animals;Humans;Dose-Response Relationship;Drug;Rats;Species Specificity;Carbon Radioisotopes;ATP Binding Cassette Transporter;Subfamily B;Member 1/*antagonists \& inhibitors;Blood-Brain Barrier/diagnostic imaging/*drug effects;Brain/diagnostic imaging/*metabolism;Calcium Channel Blockers/pharmacology;Positron-Emission Tomography/methods/statistics \& numerical data;Quinolines/blood/*pharmacology;Verapamil/*pharmacokinetics}
}

@ARTICLE{bauer2011pmdi2525,
  author = {Bauer, M.~ and Zeitlinger, M.~ and Karch, R.~ and Matzneller, P.~ and Mueller, M.~ and Langer, O.~},
  title = {P-Glycoprotein Mediated Drug-Drug Interaction at the Human Blood-Brain Barrier Studied with Positron Emission Tomography, a Comparison with Rat Data.},
  journal = {British Journal of Clinical Pharmacology},
  year = {2011},
  volume = {72},
  number = {Suppl 1: Abstracts 2011 Joint Annual Meeting of the German, Swiss, and Austrian Societies for Clinical Pharmacology and Toxicology},
  pages = {25},
  issn = {0306-5251},
  doi = {10.1111/j.1365-2125.2011.04074.x}
}

@ARTICLE{wagner2011acam111120,
  author = {Wagner, C.C.~ and Simpson, M.~ and Zeitlinger, M.~ and Bauer, M.~ and Karch, R.~ and Abrahim, A.~ and Feurstein, T.~ and Sch{\"u}tz, M.~ and Kletter, K.~ and M{\"u}ller, M.~ and Lappin, G.~ and Langer, O.~},
  title = {A Combined Accelerator Mass Spectrometry-Positron Emission Tomography Human Microdose Study with 14C- and 11C-Labelled Verapamil.},
  journal = {Clinical Pharmacokinetics},
  year = {2011},
  volume = {50},
  number = {2},
  pages = {111--120},
  issn = {1179-1926 0312-5963 0312-5963},
  doi = {10.2165/11537250-000000000-00000},
  keywords = {Humans;Male;Area Under Curve;Cross-Over Studies;Models;Biological;Half-Life;Positron-Emission Tomography;Carbon Radioisotopes;Blood-Brain Barrier;Calcium Channel Blockers/*administration \& dosage/blood/*pharmacokinetics;Tandem Mass Spectrometry;Verapamil/*administration \& dosage/blood/*pharmacokinetics}
}

@ARTICLE{kuntner2010date942953,
  author = {Kuntner, C.~ and Bankstahl, J.P.~ and Bankstahl, M.~ and Stanek, J.~ and Wanek, T.~ and Stundner, G.~ and Karch, R.~ and Brauner, R.~ and Meier, M.~ and Ding, X.~ and M{\"u}ller, M.~ and L{\"o}scher, W.~ and Langer, O.~},
  title = {Dose-Response Assessment of Tariquidar and Elacridar and Regional Quantification of P-Glycoprotein Inhibition at the Rat Blood-Brain Barrier Using (R)-[11C]Verapamil PET.},
  journal = {European Journal of Nuclear Medicine and Molecular Imaging},
  year = {2010},
  volume = {37},
  number = {5},
  pages = {942--953},
  issn = {1619-7089 1619-7070 1619-7070},
  doi = {10.1007/s00259-009-1332-5},
  keywords = {Animals;Female;Dose-Response Relationship;Drug;Rats;Rats;Sprague-Dawley;Blood Proteins/metabolism;Biological Transport/drug effects;Carbon Radioisotopes;*Positron-Emission Tomography;*Verapamil/chemistry/metabolism;Acridines/administration \& dosage/*pharmacology;ATP Binding Cassette Transporter;Subfamily B;Member 1/*antagonists \& inhibitors/metabolism;Blood-Brain Barrier/*diagnostic imaging/*drug effects/metabolism;Gene Expression Regulation/drug effects;Quinolines/administration \& dosage/*pharmacology;Stereoisomerism;Tetrahydroisoquinolines/administration \& dosage/*pharmacology}
}

@ARTICLE{bauer2010ardt510515,
  author = {Bauer, M.~ and Karch, R.~ and Neumann, F.~ and Wagner, C.C.~ and Kletter, K.~ and M{\"u}ller, M.~ and L{\"o}scher, W.~ and Zeitlinger, M.~ and Langer, O.~},
  title = {Assessment of Regional Differences in Tariquidar-Induced P-Glycoprotein Modulation at the Human Blood–Brain Barrier.},
  journal = {Journal of Cerebral Blood Flow and Metabolism},
  year = {2010},
  volume = {30},
  number = {3},
  pages = {510--515},
  issn = {1559-7016 0271-678X 0271-678X},
  doi = {10.1038/jcbfm.2009.265},
  keywords = {Adult;Humans;Male;Infusions;Intravenous;Image Processing;Computer-Assisted;Positron-Emission Tomography;Verapamil/metabolism;ATP Binding Cassette Transporter;Subfamily B;Member 1/*physiology;Blood-Brain Barrier/*drug effects/*physiology;Brain/diagnostic imaging;Calcium Channel Blockers/metabolism;Drug Resistance;Multiple/drug effects;Epilepsy/chemically induced/physiopathology;Quinolines/*pharmacology}
}

@ARTICLE{karch2010mtrh308318,
  author = {Karch, R.~ and Neumann, F.~ and Ullrich, R.~ and Heinze, G.~ and Neum{\"u}ller, J.~ and Podesser, B.K.~ and Neumann, M.~},
  title = {Methods from the Theory of Random Heterogeneous Media for Quantifying Myocardial Morphology in Normal and Dilated Hearts.},
  journal = {Annals of Biomedical Engineering},
  year = {2010},
  volume = {38},
  number = {2},
  pages = {308--318},
  issn = {1573-9686 0090-6964},
  doi = {10.1007/s10439-009-9848-1},
  keywords = {Adult;Female;Humans;Male;Middle Aged;Models;Statistical;Data Interpretation;Statistical;Computer Simulation;Myocardium/*pathology;Image Interpretation;Computer-Assisted/methods;*Models;Anatomic;*Models;Cardiovascular;Cardiomyopathies/*pathology;Myocytes;Cardiac/*pathology}
}

@ARTICLE{wagner2009apst19541961,
  author = {Wagner, C.C.~ and Bauer, M.~ and Karch, R.~ and Feurstein, T.~ and Kopp, S.~ and Chiba, P.~ and Kletter, K.~ and L{\"o}scher, W.~ and M{\"u}ller, M.~ and Zeitlinger, M.~ and Langer, O.~},
  title = {A Pilot Study to Assess the Efficacy of Tariquidar to Inhibit P-Glycoprotein at the Human Blood–Brain Barrier with (R)-11C-Verapamil and PET.},
  journal = {Journal of Nuclear Medicine},
  year = {2009},
  volume = {50},
  number = {12},
  pages = {1954--1961},
  issn = {1535-5667 0161-5505 0161-5505},
  doi = {10.2967/jnumed.109.063289},
  keywords = {Adult;Humans;Male;Pilot Projects;Kinetics;Positron-Emission Tomography;ATP Binding Cassette Transporter;Subfamily B;Member 1/*antagonists \& inhibitors/metabolism;Quinolines/*pharmacology;Blood-Brain Barrier/*diagnostic imaging/drug effects/*metabolism;Carbon Radioisotopes/chemistry;Verapamil/chemistry/*metabolism}
}

@ARTICLE{bauer2009rdpfs14s15,
  author = {Bauer, M.~ and Wagner, C.~ and Karch, R.~ and Feurstein, T.~ and Kletter, K.~ and Zeitlinger, M.~ and Mueller, M.~ and Langer, O.~},
  title = {Regional Differences in P-Glycoprotein Function at the Human Blood-Brain Barrier.},
  journal = {Journal of Cerebral Blood Flow and Metabolism},
  year = {2009},
  volume = {29},
  number = {Suppl 1: Abstracts 24th International Symposium on Cerebral Blood Flow and Metabolism/9th International Conference on Quantification of Brain Function with PET, Chicago, IL, USA, 29 June–3 July 2009},
  pages = {S14--S15},
  issn = {0271-678X},
  doi = {10.1038%2Fjcbfm.2009.115}
}

@ARTICLE{bauer2009adcp941946,
  author = {Bauer, M.~ and Karch, R.~ and Neumann, F.~ and Abrahim, A.~ and Wagner, C.C.~ and Kletter, K.~ and M{\"u}ller, M.~ and Zeitlinger, M.~ and Langer, O.~},
  title = {Age Dependency of Cerebral P-Gp Function Measured with (R)-[11C]Verapamil and PET.},
  journal = {European Journal of Clinical Pharmacology},
  year = {2009},
  volume = {65},
  number = {9},
  pages = {941--946},
  issn = {1432-1041 0031-6970 0031-6970},
  doi = {10.1007/s00228-009-0709-5},
  keywords = {Adult;Female;Humans;Male;Aged;Middle Aged;Age Factors;*Aging;Vasodilator Agents;ATP Binding Cassette Transporter;Subfamily B;Member 1/*metabolism;*Positron-Emission Tomography;*Carbon Radioisotopes;*Verapamil;Amygdala/diagnostic imaging/metabolism;Blood-Brain Barrier/metabolism;Brain/*diagnostic imaging/*metabolism;Cerebellum/diagnostic imaging/metabolism;Cerebral Cortex/diagnostic imaging/metabolism;Frontal Lobe/diagnostic imaging/metabolism}
}

@ARTICLE{bauer2009apst2323,
  author = {Bauer, M.~ and Wagner, C.~ and Karch, R.~ and Kletter, K.~ and Mueller, M.~ and Zeitlinger, M.~ and Langer, O.~},
  title = {A Pilot Study to Assess the Efficacy of Tariquidar to Inhibit Cerebral P-Glycoprotein in Humans with (R)-[C-11]Verapamil and PET.},
  journal = {Basic \& Clinical Pharmacology \& Toxicology},
  year = {2009},
  volume = {105},
  number = {Suppl 1: Abstracts 9th Congress of the European Association for Clinical Pharmacology and Therapeutics, Edinburgh, UK, 12–15 July 2009},
  pages = {23},
  issn = {1742-7835},
  doi = {https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1742-7843.2009.00436.x},
  url = {https://onlinelibrary.wiley.com/toc/17427843/2009/105/s1}
}

@ARTICLE{wagner2009cams3131,
  author = {Wagner, C.~ and Bauer, M.~ and Simpson, M.~ and Lappin, G.~ and Karch, R.~ and Feurstein, T.~ and Kletter, K.~ and Mueller, M.~ and Zeitlinger, M.~ and Langer, O.~},
  title = {Combined Accelerator Mass Spectrometry and Positron Emission Tomography Microdosing to Assess Plasma and Brain Tissue Pharmacokinetics of Verapamil in Humans.},
  journal = {Basic \& Clinical Pharmacology \& Toxicology},
  year = {2009},
  volume = {105},
  number = {Suppl 1: Abstracts 9th Congress of the European Association for Clinical Pharmacology and Therapeutics, Edinburgh, UK, 12–15 July 2009},
  pages = {31},
  issn = {1742-7835},
  doi = {10.1111/j.1742-7843.2009.00436.x}
}

@ARTICLE{sauermann2009apch3636,
  author = {Sauermann, R.~ and Feurstein, T.~ and Karch, R.~ and Puespoek, A.~ and Langenberger, H.~ and Jaeger, W.~ and Miksits, M.~ and Zeitlinger, M.~},
  title = {Abscess Penetration of Cefpirome in Humans.},
  journal = {Basic \& Clinical Pharmacology \& Toxicology},
  year = {2009},
  volume = {105},
  number = {Suppl 1: Abstracts 9th Congress of the European Association for Clinical Pharmacology and Therapeutics, Edinburgh, UK, 12–15 July 2009},
  pages = {36},
  issn = {1742-7835},
  doi = {10.1111/j.1742-7843.2009.00436.x}
}

@ARTICLE{kuntner2009lsap236240,
  author = {Kuntner, C.~ and Kesner, A.L.~ and Bauer, M.~ and Kremslehner, R.~ and Wanek, T.~ and Mandler, M.~ and Karch, R.~ and Stanek, J.~ and Wolf, T.~ and M{\"u}ller, M.~ and Langer, O.~},
  title = {Limitations of Small Animal PET Imaging with [18F]FDDNP and FDG for Quantitative Studies in a Transgenic Mouse Model of Alzheimer’s Disease.},
  journal = {Molecular Imaging and Biology},
  year = {2009},
  volume = {11},
  number = {4},
  pages = {236--240},
  issn = {1860-2002 1536-1632},
  doi = {10.1007/s11307-009-0198-z},
  keywords = {Animals;Statistics;Nonparametric;Mice;Phantoms;Imaging;Imaging;Three-Dimensional/methods;Positron-Emission Tomography/*methods;*Disease Models;Animal;Alzheimer Disease/*diagnostic imaging/pathology;Amyloid beta-Peptides/metabolism;Brain Chemistry;Brain/*diagnostic imaging/pathology;Fluorodeoxyglucose F18/*pharmacokinetics;Mice;Transgenic;Nitriles/*pharmacokinetics;Radiopharmaceuticals/*pharmacokinetics}
}

@ARTICLE{bauer2009dbbpabstract 606,
  author = {Bauer, M.~ and Karch, R.~ and Neumann, F.~ and Abrahim, A.~ and Kletter, K.~ and Mueller, M.~ and Langer, O.~},
  title = {Decreased Blood-Brain Barrier P-Glycoprotein Function with Aging.},
  journal = {Journal of Nuclear Medicine},
  year = {2009},
  volume = {50},
  number = {Suppl 2},
  pages = {Abstract 606},
  issn = {0161-5505},
  url = {http://jnm.snmjournals.org/content/50/supplement_2/606.abstract?sid=bff8ccfb-2b3a-4435-a3d1-7429b1791ed6}
}

@ARTICLE{bankstahl2009tpia119119,
  author = {Bankstahl, J.~ and Kuntner, C.~ and Abrahim, A.~ and Karch, R.~ and Langer, O.~ and Loescher, W.~},
  title = {Tariquidar-Induced P-Glycoprotein Inhibition at the Rat Blood-Brain Barrier Studied by Positron Emission Tomography with (R)-[11C]Verapamil.},
  journal = {Epilepsia},
  year = {2009},
  volume = {50},
  number = {Suppl 4: Abstracts 8th European Congress on Epileptology, Berlin, Germany, 21–25 September 2008},
  pages = {119},
  issn = {0013-9580},
  url = {https://onlinelibrary.wiley.com/toc/15281167/2009/50/s4}
}

@ARTICLE{bankstahl2008tpia13281335,
  author = {Bankstahl, J.P.~ and Kuntner, C.~ and Abrahim, A.~ and Karch, R.~ and Stanek, J.~ and Wanek, T.~ and Wadsak, W.~ and Kletter, K.~ and M{\"u}ller, M.~ and L{\"o}scher, W.~ and Langer, O.~},
  title = {Tariquidar-Induced P-Glycoprotein Inhibition at the Rat Blood–Brain Barrier Studied with (R)-11C-Verapamil and PET.},
  journal = {Journal of Nuclear Medicine},
  year = {2008},
  volume = {49},
  number = {8},
  pages = {1328--1335},
  issn = {0161-5505 1535-5667 0161-5505},
  doi = {10.2967/jnumed.108.051235},
  keywords = {Animals;Female;Models;Biological;Rats;Rats;Wistar;Tissue Distribution;Carbon Radioisotopes;Biological Transport;Stereoisomerism;Quinolines/*pharmacology;ATP Binding Cassette Transporter;Subfamily B;Member 1/antagonists \& inhibitors/*metabolism;Blood-Brain Barrier/*metabolism;Calcium Channel Blockers/chemistry/*pharmacokinetics;Positron-Emission Tomography/methods;Verapamil/chemistry/*pharmacokinetics}
}

@ARTICLE{abrahim2008pmre116123,
  author = {Abrahim, A.~ and Luurtsema, G.~ and Bauer, M.~ and Karch, R.~ and Lubberink, M.~ and Pataraia, E.~ and Joukhadar, C.~ and Kletter, K.~ and Lammertsma, A.A.~ and Baumgartner, C.~ and M{\"u}ller, M.~ and Langer, O.~},
  title = {Peripheral Metabolism of (R)-[11C]Verapamil in Epilepsy Patients.},
  journal = {European Journal of Nuclear Medicine and Molecular Imaging},
  year = {2008},
  volume = {35},
  number = {1},
  pages = {116--123},
  issn = {1619-7089 1619-7070},
  doi = {10.1007/s00259-007-0556-5},
  keywords = {Adult;Female;Humans;Male;Middle Aged;Case-Control Studies;Injections;Chromatography;High Pressure Liquid;Carbon Radioisotopes;Stereoisomerism;Calcium Channel Blockers/administration \& dosage/blood/*chemistry/*metabolism;Epilepsy/blood/*metabolism;Solid Phase Extraction;Verapamil/administration \& dosage/blood/*chemistry/*metabolism}
}

@ARTICLE{bauer2007ritlbp1403u,
  author = {Bauer, M.~ and Langer, O.~ and Hammers, A.~ and Karch, R.~ and Pataraia, E.~ and Koepp, M.J.~ and Abrahim, A.~ and Luurtsema, G.~ and Kletter, K.~ and Baumgartner, C.~ and Muller, M.~},
  title = {Regionally Increased Temporal Lobe Efflux of R-[11]Verapamil Occurs in Some Patients with Therapy Refractory Epilepsy.},
  journal = {Journal of Cerebral Blood Flow and Metabolism},
  year = {2007},
  volume = {27},
  number = {Suppl 1, Abstracts 23rd International Symposium on Cerebral Blood Flow, Metabolism and Function, 20–24 May 2007, Osaka, Japan},
  pages = {BP14--03U},
  doi = {10.1038/jcbfm.2007.100},
  url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-36348939784\&partnerID=40\&md5=e918a2378393fa0054e6c312e0cf4607}
}

@ARTICLE{langer2007peap17741784,
  author = {Langer, O.~ and Bauer, M.~ and Hammers, A.~ and Karch, R.~ and Pataraia, E.~ and Koepp, M.J.~ and Abrahim, A.~ and Luurtsema, G.~ and Brunner, M.~ and Sunder-Plassmann, R.~ and Zimprich, F.~ and Joukhadar, C.~ and Gentzsch, S.~ and Dudczak, R.~ and Kletter, K.~ and M{\"u}ller, M.~ and Baumgartner, C.~},
  title = {Pharmacoresistance in Epilepsy: A Pilot Pet Study with the P-Glycoprotein Substrate.},
  journal = {Epilepsia},
  year = {2007},
  volume = {48},
  number = {9},
  pages = {1774--1784},
  issn = {0013-9580 0013-9580},
  doi = {10.1111/j.1528-1167.2007.01116.x},
  keywords = {Adult;Female;Humans;Male;Middle Aged;Pilot Projects;Models;Biological;Age of Onset;Tissue Distribution;Drug Resistance;ATP Binding Cassette Transporter;Subfamily B;Member 1/*metabolism;*Carbon Radioisotopes;*Verapamil;Brain/*diagnostic imaging/metabolism;Epilepsies;Partial/*diagnostic imaging/*drug therapy/metabolism;Functional Laterality/physiology;Hippocampus/diagnostic imaging/metabolism;Positron-Emission Tomography/*statistics \& numerical data;Radiopharmaceuticals;Temporal Lobe/diagnostic imaging/metabolism}
}

@ARTICLE{karch2006agpf599611,
  author = {Karch, R.~ and Neumann, M.~ and Neumann, F.~ and Ullrich, R.~ and Neum{\"u}ller, J.~ and Schreiner, W.~},
  title = {A Gibbs Point Field Model for the Spatial Pattern of Coronary Capillaries.},
  journal = {Physica A: Statistical Mechanics and Its Applications},
  year = {2006},
  volume = {369},
  number = {2},
  pages = {599--611},
  doi = {10.1016/j.physa.2006.02.018},
  url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-33745684691\&doi=10.1016%2fj.physa.2006.02.018\&partnerID=40\&md5=19f138af2cd4898b0e087e4e80702df6}
}

@ARTICLE{bauer2006apet216227,
  author = {Bauer, M.~ and Langer, O.~ and Dal-Bianco, P.~ and Karch, R.~ and Brunner, M.~ and Abrahim, A.~ and Lanzenberger, R.~ and Hofmann, A.~ and Joukhadar, C.~ and Carminati, P.~ and Ghirardi, O.~ and Piovesan, P.~ and Forloni, G.~ and Corrado, M.E.~ and Lods, N.~ and Dudczak, R.~ and Auff, E.~ and Kletter, K.~ and M{\"u}ller, M.~},
  title = {A Positron Emission Tomography Microdosing Study with a Potential Antiamyloid Drug in Healthy Volunteers and Patients with Alzheimer’s Disease.},
  journal = {Clinical Pharmacology and Therapeutics},
  year = {2006},
  volume = {80},
  number = {3},
  pages = {216--227},
  issn = {0009-9236 0009-9236},
  doi = {10.1016/j.clpt.2006.05.007},
  keywords = {Adult;Female;Humans;Male;Time Factors;Aged;Area Under Curve;Dose-Response Relationship;Drug;Pilot Projects;Injections;Intravenous;Chromatography;High Pressure Liquid;Tissue Distribution;Carbon Radioisotopes;Positron-Emission Tomography/*methods;Blood-Brain Barrier/metabolism;Alzheimer Disease/*drug therapy/metabolism;Amyloid/*antagonists \& inhibitors/metabolism;Biological Availability;Molecular Structure;Naphthols/blood/*pharmacokinetics/therapeutic use;Neuroprotective Agents/blood/pharmacokinetics/therapeutic use}
}

@ARTICLE{schreiner2006oats416429,
  author = {Schreiner, W.~ and Karch, R.~ and Neumann, M.~ and Neumann, F.~ and Szawlowski, P.~ and Roedler, S.~},
  title = {Optimized Arterial Trees Supplying Hollow Organs.},
  journal = {Medical Engineering \& Physics},
  year = {2006},
  volume = {28},
  number = {5},
  pages = {416--429},
  issn = {1350-4533 1350-4533},
  doi = {10.1016/j.medengphy.2005.07.019},
  keywords = {Humans;*Algorithms;Computer Simulation;Blood Flow Velocity;Blood Pressure;*Models;Cardiovascular;*Ventricular Function;Arteries/*physiology;Coronary Circulation/*physiology;Viscera/*blood supply/*physiology}
}

@ARTICLE{sauermann2005aapf44484454,
  author = {Sauermann, R.~ and Karch, R.~ and Langenberger, H.~ and Kettenbach, J.~ and Mayer-Helm, B.~ and Petsch, M.~ and Wagner, C.~ and Sautner, T.~ and Gattringer, R.~ and Karanikas, G.~ and Joukhadar, C.~},
  title = {Antibiotic Abscess Penetration: Fosfomycin Levels Measured in Pus and Simulated Concentration-Time Profiles.},
  journal = {Antimicrobial Agents and Chemotherapy},
  year = {2005},
  volume = {49},
  number = {11},
  pages = {4448--4454},
  issn = {0066-4804 1098-6596 0066-4804},
  doi = {10.1128/AAC.49.11.4448-4454.2005},
  keywords = {Adult;Female;Humans;Male;Aged;Middle Aged;Aged;80 and over;Abscess/*metabolism;Anti-Bacterial Agents/*pharmacokinetics;Fosfomycin/administration \& dosage/*pharmacokinetics;Permeability}
}

@ARTICLE{nadler2005eegd829844,
  author = {Nadler, B.A.~ and Karch, R.~ and Neumann, M.~ and Neumann, F.~ and Aharinejad, S.~ and Schreiner, W.~},
  title = {Error Estimation of Geometrical Data Obtained by Histomorphometry of Oblique Vessel Sections: A Computer Model Study.},
  journal = {Computers in Biology and Medicine},
  year = {2005},
  volume = {35},
  number = {9},
  pages = {829--844},
  issn = {0010-4825 0010-4825},
  doi = {10.1016/j.compbiomed.2004.07.003},
  keywords = {Animals;Swine;*Computer Simulation;Blood Vessels/*anatomy \& histology}
}

@ARTICLE{langer2005cpmv18351841,
  author = {Langer, O.~ and Karch, R.~ and M{\"u}ller, U.~ and Dobrozemsky, G.~ and Abrahim, A.~ and Zeitlinger, M.~ and Lackner, E.~ and Joukhadar, C.~ and Dudczak, R.~ and Kletter, K.~ and M{\"u}ller, M.~ and Brunner, M.~},
  title = {Combined PET and Microdialysis for in Vivo Assessment of Intracellular Drug Pharmacokinetics in Humans.},
  journal = {Journal of Nuclear Medicine},
  year = {2005},
  volume = {46},
  number = {11},
  pages = {1835--1841},
  issn = {0161-5505 0161-5505},
  url = {http://jnm.snmjournals.org/content/46/11/1835.long},
  keywords = {Adult;Humans;Male;*Algorithms;*Models;Biological;Computer Simulation;Kinetics;Organ Specificity;Tissue Distribution;Positron-Emission Tomography/*methods;Ciprofloxacin/*pharmacokinetics/therapeutic use;Fluorine Radioisotopes/pharmacokinetics/therapeutic use;Image Interpretation;Computer-Assisted/*methods;Intracellular Fluid/metabolism;Metabolic Clearance Rate;Microdialysis/*methods;Muscle;Skeletal/diagnostic imaging/*metabolism}
}

@ARTICLE{brunner2005ifhd182190,
  author = {Brunner, M.~ and Langer, O.~ and Sunder-Plassmann, R.~ and Dobrozemsky, G.~ and M{\"u}ller, U.~ and Wadsak, W.~ and Krcal, A.~ and Karch, R.~ and Mannhalter, C.~ and Dudczak, R.~ and Kletter, K.~ and Steiner, I.~ and Baumgartner, C.~ and M{\"u}ller, M.~},
  title = {Influence of Functional Haplotypes in the Drug Transporter Gene ABCB1 on Central Nervous System Drug Distribution in Humans.},
  journal = {Clinical Pharmacology and Therapeutics},
  year = {2005},
  volume = {78},
  number = {2},
  pages = {182--190},
  issn = {0009-9236 0009-9236},
  doi = {10.1016/j.clpt.2005.04.011},
  keywords = {Adult;Humans;Male;Area Under Curve;Case-Control Studies;Double-Blind Method;Haplotypes;Injections;Intravenous;Tissue Distribution;Positron-Emission Tomography;*Genes;MDR;Carbon Radioisotopes/administration \& dosage/pharmacokinetics;Central Nervous System Agents/administration \& dosage/*pharmacokinetics;Central Nervous System/*metabolism;Verapamil/administration \& dosage/*pharmacokinetics}
}

@ARTICLE{karch2005spcc135144,
  author = {Karch, R.~ and Neumann, F.~ and Ullrich, R.~ and Neum{\"u}ller, J.~ and Podesser, B.K.~ and Neumann, M.~ and Schreiner, W.~},
  title = {The Spatial Pattern of Coronary Capillaries in Patients with Dilated, Ischemic, or Inflammatory Cardiomyopathy.},
  journal = {Cardiovascular Pathology},
  year = {2005},
  volume = {14},
  number = {3},
  pages = {135--144},
  issn = {1054-8807 1054-8807},
  doi = {10.1016/j.carpath.2005.03.003},
  keywords = {Adult;Female;Humans;Male;Retrospective Studies;Aged;Middle Aged;Models;Biological;Computer Simulation;Capillaries;*Coronary Circulation;Cardiomyopathy;Dilated/*pathology/surgery;Coronary Vessels/*pathology;Heart Failure/pathology/surgery;Heart Transplantation;Myocardial Ischemia/*pathology/surgery;Myocarditis/*pathology/surgery}
}

@ARTICLE{karch2003fpph307321,
  author = {Karch, R.~ and Neumann, F.~ and Podesser, B.K.~ and Neumann, M.~ and Szawlowski, P.~ and Schreiner, W.~},
  title = {Fractal Properties of Perfusion Heterogeneity in Optimized Arterial Trees: A Model Study.},
  journal = {Journal of General Physiology},
  year = {2003},
  volume = {122},
  number = {3},
  pages = {307--321},
  issn = {0022-1295 1540-7748 0022-1295},
  doi = {10.1085/jgp.200208747},
  keywords = {Animals;Computer Simulation;Regional Blood Flow;*Models;Cardiovascular;Arteries/*physiology;*Fractals}
}

@ARTICLE{karch2003vpao548563,
  author = {Karch, R.~ and Neumann, F.~ and Neumann, M.~ and Szawlowski, P.~ and Schreiner, W.~},
  title = {Voronoi Polyhedra Analysis of Optimized Arterial Tree Models.},
  journal = {Annals of Biomedical Engineering},
  year = {2003},
  volume = {31},
  number = {5},
  pages = {548--563},
  issn = {0090-6964 0090-6964},
  doi = {10.1114/1.1566444},
  keywords = {Humans;*Algorithms;Models;Statistical;Computer Simulation;Quality Control;Regional Blood Flow/physiology;Retina;*Models;Anatomic;*Models;Cardiovascular;Anatomy;Cross-Sectional/methods;Arteries/*anatomy \& histology/*growth \& development/physiology;Retinal Vessels/physiology}
}

@ARTICLE{schreiner2003hpia285301,
  author = {Schreiner, W.~ and Karch, R.~ and Neumann, M.~ and Neumann, F.~ and Roedler, S.M.~ and Heinze, G.~},
  title = {Heterogeneous Perfusion Is a Consequence of Uniform Shear Stress in Optimized Arterial Tree Models.},
  journal = {Journal of Theoretical Biology},
  year = {2003},
  volume = {220},
  number = {3},
  pages = {285--301},
  issn = {0022-5193 0022-5193},
  doi = {10.1006/jtbi.2003.3136},
  keywords = {Humans;Stress;Mechanical;Blood Pressure/physiology;*Computer Simulation;*Hemorheology;*Models;Cardiovascular;Arteries/*physiology}
}

@ARTICLE{karch2000fcoa250264,
  author = {Karch, R.~ and Neumann, F.~ and Neumann, M.~ and Schreiner, W.~},
  title = {Functional Characteristics of Optimized Arterial Tree Models Perfusing Volumes of Different Thickness and Shape.},
  journal = {Journal of Vascular Research},
  year = {2000},
  volume = {37},
  number = {4},
  pages = {250--264},
  issn = {1018-1172 1018-1172},
  doi = {10.1159/000025739},
  keywords = {Computer Simulation;*Models;Cardiovascular;*Blood Circulation;*Blood Volume;Arteries/*anatomy \& histology/*physiology}
}

@ARTICLE{karch2000sgoa495511,
  author = {Karch, R.~ and Neumann, F.~ and Neumann, M.~ and Schreiner, W.~},
  title = {Staged Growth of Optimized Arterial Model Trees.},
  journal = {Annals of Biomedical Engineering},
  year = {2000},
  volume = {28},
  number = {5},
  pages = {495--511},
  issn = {0090-6964 0090-6964},
  doi = {10.1114/1.290},
  keywords = {Algorithms;Humans;Models;Anatomic;*Models;Cardiovascular;Arteries/*anatomy \& histology/*growth \& development/physiology;Biomedical Engineering;Coronary Vessels/anatomy \& histology/growth \& development/physiology;Heart/anatomy \& histology/growth \& development/physiology}
}

@ARTICLE{schreiner1999ssda2745,
  author = {Schreiner, W.~ and Neumann, F.~ and Karch, R.~ and Neumann, M.~ and Roedler, S.M.~ and End, A.~},
  title = {Shear Stress Distribution in Arterial Tree Models, Generated by Constrained Constructive Optimization.},
  journal = {Journal of Theoretical Biology},
  year = {1999},
  volume = {198},
  number = {1},
  pages = {27--45},
  issn = {0022-5193 0022-5193},
  doi = {10.1006/jtbi.1999.0898},
  keywords = {Humans;*Computer Simulation;*Stress;Mechanical;*Models;Cardiovascular;Arteries/*anatomy \& histology;Blood Viscosity/physiology}
}

@ARTICLE{karch1999atma1938,
  author = {Karch, R.~ and Neumann, F.~ and Neumann, M.~ and Schreiner, W.~},
  title = {A Three-Dimensional Model for Arterial Tree Representation, Generated by Constrained Constructive Optimization.},
  journal = {Computers in Biology and Medicine},
  year = {1999},
  volume = {29},
  number = {1},
  pages = {19--38},
  issn = {0010-4825 0010-4825},
  doi = {10.1016/s0010-4825(98)00045-6},
  keywords = {Algorithms;Humans;*Models;Biological;Blood Pressure/physiology;Regional Blood Flow/physiology;*Computer Simulation;Hemodynamics/physiology;Vasoconstriction/physiology;Vascular Resistance/physiology;Vasodilation/physiology;Blood Viscosity/physiology;Arteries/anatomy \& histology/*physiology;Blood Volume/physiology;Microcirculation/physiology;Neovascularization;Physiologic;Stochastic Processes}
}

@INCOLLECTION{schreiner1997gtot371380,
  author = {Schreiner, W.~ and Neumann, F.~ and Karch, R.~ and Neumann, M.~ and End, A.~ and Roedler, S.M.~},
  title = {Geometrical and Topological Optimization and Their Relation to the Bifurcation Laws in Optimized Arterial Tree Models.},
  booktitle = {Computer Aided Optimum Design of Structures V. Proceedings of the Fifth International Conference on Computer Aided Optimum Design of Structures (OPTI 97), Rome, Italy, 8–10 September 1997},
  publisher = {Wit Press},
  year = {1997},
  editor = {Hernandez,S.;Brebbia,C.A.},
  number = {31},
  series = {WIT Transactions on the Built Environment},
  pages = {371--380},
  address = {Southampton},
  url = {https://www.witpress.com/elibrary/wit-transactions-on-the-built-environment/31/8234}
}

@INCOLLECTION{karch1997toat312,
  author = {Karch, R.~ and Schreiner, W.~ and Neumann, M.~ and Neumann, F.~},
  title = {Three-Dimensional Optimization of Arterial Tree Models.},
  booktitle = {Simulations in Biomedicine IV. Proceedings of the Fourth International Conference on Computers in Biomedicine (BIOMED), Umbria, Italy, 9–11 June 1997},
  publisher = {Wit Press},
  year = {1997},
  editor = {Power,H.;Brebbia,C.H.;Kenny,J.},
  number = {4},
  series = {WIT Transactions on Biomedicine and Health},
  pages = {3--12},
  address = {Southampton},
  url = {https://www.witpress.com/Secure/elibrary/papers/BIO97/BIO97001FU.pdf}
}

@INCOLLECTION{neumann1997sdes2335,
  author = {Neumann, M.~ and Neumann, F.~ and Karch, R.~ and Schreiner, W.~},
  title = {Size and Discretization Effects in Simulations of Coronary Hemodynamics.},
  booktitle = {Simulations in Biomedicine IV. Proceedings of the Fourth International Conference on Computers in Biomedicine (BIOMED), Umbria, Italy, 9–11 June 1997},
  publisher = {Wit Press},
  year = {1997},
  editor = {Power,H.;Brebbia,C.H.;Kenny,J.},
  number = {4},
  series = {WIT Transactions on Biomedicine and Health},
  pages = {23--35},
  address = {Southampton},
  url = {https://www.witpress.com/Secure/elibrary/papers/BIO97/BIO97003FU.pdf}
}

@INCOLLECTION{neumann1997scat3746,
  author = {Neumann, M.~ and Schreiner, W.~ and Karch, R.~ and Neumann, F.~},
  title = {Structure of Computer-Generated Arterial Trees with Different Optimization Target Functions.},
  booktitle = {Simulations in Biomedicine IV. Proceedings of the Fourth International Conference on Computers in Biomedicine (BIOMED), Umbria, Italy, 9–11 June 1997},
  publisher = {Wit Press},
  year = {1997},
  editor = {Power,H.;Brebbia,C.H.;Kenny,J.},
  number = {4},
  series = {WIT Transactions on Biomedicine and Health},
  pages = {37--46},
  address = {Southampton},
  url = {https://www.witpress.com/Secure/elibrary/papers/BIO97/BIO97004FU.pdf}
}

@INCOLLECTION{schreiner1997lsgs125134,
  author = {Schreiner, W.~ and Neumann, F.~ and Neumann, M.~ and Karch, R.~},
  title = {Local Symmetry and Global Structure of Coronary Arterial Tree Models Generated by Constrained Constructive Optimization.},
  booktitle = {Simulations in Biomedicine IV. Proceedings of the Fourth International Conference on Computers in Biomedicine (BIOMED), Umbria, Italy, 9–11 June 1997},
  publisher = {Wit Press},
  year = {1997},
  editor = {Power,H.;Brebbia,C.H.;Kenny,J.},
  number = {4},
  series = {WIT Transactions on Biomedicine and Health},
  pages = {125--134},
  address = {Southampton},
  url = {https://www.witpress.com/Secure/elibrary/papers/BIO97/BIO97012FU.pdf}
}

@ARTICLE{schreiner1997lbac129140,
  author = {Schreiner, W.~ and Neumann, F.~ and Neumann, M.~ and Karch, R.~ and End, A.~ and Roedler, S.M.~},
  title = {Limited Bifurcation Asymmetry in Coronary Arterial Tree Models Generated by Constrained Constructive Optimization.},
  journal = {Journal of General Physiology},
  year = {1997},
  volume = {109},
  number = {2},
  pages = {129--140},
  issn = {0022-1295 1540-7748 0022-1295},
  doi = {10.1085/jgp.109.2.129},
  keywords = {Algorithms;Linear Models;Computer Simulation;Regression Analysis;Models;Anatomic;Blood Pressure/physiology;Coronary Circulation/physiology;Coronary Vessels/*anatomy \& histology/physiology;Viscosity}
}

@INCOLLECTION{neumann1996vcam259268,
  author = {Neumann, F.~ and Neumann, M.~ and Karch, R.~ and Schreiner, W.~},
  title = {Visualization of Computer-Generated Arterial Model Trees.},
  booktitle = {Simulation Modelling in Bioengineering. Proceedings of the First International BIOSIM ’96 Conference, Mérida, Venezuela, 23–25 October 1996},
  publisher = {WIT Press},
  year = {1996},
  editor = {Cerrolaza,M.;Jugo,D.;Brebbia,C.A.},
  number = {3},
  series = {WIT Transactions on Biomedicine and Health},
  pages = {259--268},
  address = {Southampton},
  url = {https://www.witpress.com/Secure/elibrary/papers/BSIM96/BSIM96024FU.pdf}
}

@INCOLLECTION{neumann1996srsc3951,
  author = {Neumann, M.~ and Neumann, F.~ and Karch, R.~ and Schreiner, W.~},
  title = {Spatially Resolved Simulation of Coronary Hemodynamics.},
  booktitle = {Simulation Modelling in Bioengineering. Proceedings of the First International BIOSIM ’96 Conference, Mérida, Venezuela, 23–25 October 1996},
  publisher = {WIT Press},
  year = {1996},
  editor = {Cerrolaza,M.;Jugo,D.;Brebbia,C.A.},
  number = {3},
  series = {WIT Transactions on Biomedicine and Health},
  pages = {39--51},
  address = {Southampton},
  url = {https://www.witpress.com/Secure/elibrary/papers/BSIM96/BSIM96004FU.pdf}
}