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Tutorials and Reviews

Institute of Clinical Biometrics

Contributing to interdisciplinary knowledge transfer, we have published a number of tutorials and reviews on the following topics:

Heinze G, Christensen J, Haller MC (2022): “Modeling pulse wave velocity trajectories-challenges, opportunities, and pitfalls.” Kidney Int 101(3): 459-462. doi:10.1016/j.kint.2021.12.025.

Gregorich M, Strohmaier S, Dunkler D, Heinze G (2021): “Regression with Highly Correlated Predictors: Variable Omission Is Not the Solution.” Int. J. Environ. Res. Public Health, 18(8): 12. doi:10.3390/ijerph18084259

Dunkler, D., Haller, M., Oberbauer, R. and Heinze, G. (2020): "To test or to estimate? P‐values versus effect sizes", Transpl Int, 33: 50-55. doi:10.1111/tri.13535

Heinze G, Wallisch C, Dunkler D (2018): "Variable selection - A review and recommendations for the practicing statistician", Biom J 60:431-449. doi:10.1002/bimj.201700067, Level: advanced

Mansournia MA, Geroldinger A, Greenland S, Heinze G (2018): "Separation in Logistic Regression: Causes, Consequences, and Control", Am J Epidemiol 187:864-870. doi:10.1093/aje/kwx299, Level: advanced

Heinze G, Dunkler D (2017): "Five myths about variable selection", Transplant International 30:6-10. doi:10.1111/tri.12895, Level: beginner

Boucquemont J, Heinze G, Jager KJ, Oberbauer R, Leffondre K (2014): "Regression methods for investigating risk factors of chronic kidney disease outcomes: the state of the art", BMC Nephrology 15:45-45. doi:10.1186/1471-2369-15-45, Level: beginner

Leffondre,K., Boucquemont,J., Tripepi,G., Stel,V., Heinze,G., Dunkler,D. (2014): "Analysis of risk factors associated with renal function trajectory over time: a comparison of different statistical approaches", ndt Nephrology Dialysis Transplantation, (published online), doi:10.1093/ndt/gfu320, Level: advanced

Leffondre,K., Jager,K.J., Boucquemont,J., Stel,V.S., Heinze,G. (2013): "Representation of exposures in regression analysis and interpretation of regression coefficients: basic concepts and pitfalls", Nephrology Dialysis Transplantation, 29 (10), 1806-1814. doi:10.1093/ndt/gft500, Level: beginner

Tripepi,G., Heinze,G., Jager,K.J., Stel,V.S., Dekker,F.W. & Zoccali,C. (2013): "Risk prediction models", Nephrology Dialysis Transplantation, 28, 1975-1980. doi:10.1093/ndt/gft095, Level: advanced

Heinze, G., Jüni, P. (2011): An overview of the objectives of and the approaches to propensity score analyses, European Heart Journal 32, 1704 ? 1708. doi:10.1093/eurheartj/ehr031, Level: advanced

Gleiss A, Oberbauer R, Heinze G (2018): "An unjustified benefit: immortal time bias in the analysis of time-dependent events", Transpl Int 31:125-130. doi:10.1111/tri.13081, Level: advanced

Gleiss A, Zeillinger R, Braicu EI, Trillsch F, Vergote I, Schemper M (2016): "Statistical controversies in clinical research: the importance of importance", Annals of Oncology 27:1185-1189. doi:10.1093/annonc/mdw159, Level: advanced

Stel VS, Heinze G, Tripepi G, Zoccali C, Jager KJ (2015): "Seven essential tools of a cardiologist's survival kit", International Journal of Cardiology 191:87-89. doi:10.1016/j.ijcard.2015.04.246, Level: beginner

Wolbers M, Koller MT, Stel VS, Schaer B, Jager KJ, Leffondre K, Heinze G (2014): "Competing risks analysis: objectives and approaches", European Haert Journal 35:2936-2941. doi:10.1093/eurheartj/ehu131, Level: advanced

Heinzl H (2009): "Kaplan-Meier-Kurven und die Hazard Ratio", krebs:hilfe! 2:X-XI. Full text PDF (German only), Level: beginner

Heinzl H (1998): "Flexible Beschreibung der Wechselwirkung zwischen einer binären zeitabhängigen Kovariablen und der Zeit im Cox'schen Modell am Beispiel von Transplantationsdaten", Berichte der GKC 21:31-36. Full text PDF (German only), Level: advanced

Schemper, M. & Smith, T. L. (1996): A note on quantifying follow-up in studies of failure time, Controlled Clinical Trials 17, 343-346. Full text PDF, Level: advanced

Heinzl H, Benner A (2019): "Three brief pieces of statistical advice for medical peer reviewers", Eur J Clin Invest. 49(11):e13171. doi:10.1111/eci.13171, Level: beginner

Gleiss A (2017): "Identifiability of Components of Complex Interventions Using Factorial Designs", J Altern Complement Med 23:569-574. doi:10.1089/acm.2017.0075, Level: beginner

Dunkler, D., Sanchez-Cabo, F., Heinze, G. (2011): "Statistical Analysis Principles for Omics Data", Chapter 5 in Bioinformatics for Omics Data (Hg.: Mayer, B.), Reihe: 719 - Methods in Molecular Biology, Humana Press

Mittlböck M (2009): Einführung in das statistische Testen, krebs:hilfe 2:2009:VI-VII. Full text PDF (German only), Level: beginner

Mittlboeck M (2008): "Critical Appraisal of Randomized Clinical Trials: Can We Have Faith in the Conclusions?", Breast Care 3:341-346. doi:10.1159/000157168 , Level: beginner

Heinzl H, Mittlböck M (2007): "Eine Einführung zu chirurgischen Lernkurvenstudien", Forum der Medizin_Dokumentation und Medizin_Informatik 1/2001:30-33. Full text PDF (German only), Level: beginner

Draxler W, Mittlböck M (2006): "Basic principles in the planning of clinical trials in surgical oncology", European Surgery 38:27-32. doi:10.1007/s10353-006-0211-6, Level: beginner

Moreover, on the following pages we provide links to external collections of tutorials and to freely available books on statistical modelling and causal inference:

External Collections

Freely Available Books